INCADRONIC ACID

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H19NO6P2
Molecular Weight	287.1871
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OP(O)(=O)C(NC1CCCCCC1)P(O)(O)=O

InChI

InChIKey=LWRDQHOZTAOILO-UHFFFAOYSA-N

InChI=1S/C8H19NO6P2/c10-16(11,12)8(17(13,14)15)9-7-5-3-1-2-4-6-7/h7-9H,1-6H2,(H2,10,11,12)(H2,13,14,15)

HIDE SMILES / InChI

Molecular Formula	C8H19NO6P2
Molecular Weight	287.1871
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/24683210 | https://www.ncbi.nlm.nih.gov/pubmed/16237529 | https://www.ncbi.nlm.nih.gov/pubmed/22484715

Incadronate (Disodium Cycloheptylaminomethylene diphosphate) is used to treat malignancy-associated hypercalcemia (MAH) in Japan. Experiments on rodents have revealed that this drug could be an effective agent for the treatment of various arthritic conditions, including human rheumatoid arthritis. In addition was shown, that incadronate induced growth inhibition and apoptotic death of pancreatic cancer cells. Incadronate also inhibited migration presumably by preventing the activation of Rho by lysophosphatidic acid. Thus, this drug can be of value in regimens for the treatment of pancreatic cancer.

Approval Year

PubMed

Title	Date	PubMed
Hydronium (cycloheptylammonio)methylene-1,1-bisphosphonate (hydronium incadronate).	2003 Feb	12574666
Incadronate disodium inhibits joint destruction and periarticular bone loss only in the early phase of rat adjuvant-induced arthritis.	2005	15981025
The protective effects of incadronate on inflammation and joint destruction in established rat adjuvant arthritis.	2006 Jun	16237529
Incadronate induces cell detachment and apoptosis in prostatic PC-3 cells.	2007 Mar-Apr	17465222
Clinical evaluation of incadronate in korean patients with malignancy-associated hypercalcemia: An open-label, multicenter study.	2007 May	24683210

Patents

Sample Use Guides

In Vivo Use Guide

Korean patients with malignancy-associated hypercalcemia (MAH) were given a single 10-mg IV infusion of incadronate over 2 to 4 hours in 500 to 1000 mL of normal saline

Route of Administration: Intravenous

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:38:45 GMT 2023` Edited by `admin` on `Fri Dec 15 16:38:45 GMT 2023`
Record UNII	G5C4M8847E
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

INCADRONIC ACID

Official Name

English

INCADRONIC ACID [MART.]

Common Name

English

incadronic acid [INN]

Common Name

English

((CYCLOHEPTYLAMINO)METHYLENE)DIPHOSPHONIC ACID

Systematic Name

English

Incadronic acid [WHO-DD]

Common Name

English

INCADRONIC ACID [MI]

Common Name

English

NSC-723271

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C443