INCADRONATE DISODIUM

Details

Stereochemistry	ACHIRAL
Molecular Formula	C9H16O6P2.2Na.2H
Molecular Weight	330.1627
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H+].[H+].[Na+].[Na+].[O-]P([O-])(=O)C(CC1CCCCCC1)P([O-])([O-])=O

InChI

InChIKey=RLIRIVMEKVNVQX-UHFFFAOYSA-L

InChI=1S/C9H20O6P2.2Na/c10-16(11,12)9(17(13,14)15)7-8-5-3-1-2-4-6-8;;/h8-9H,1-7H2,(H2,10,11,12)(H2,13,14,15);;/q;2*+1/p-2

HIDE SMILES / InChI

Molecular Formula	Na
Molecular Weight	22.9898
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	H
Molecular Weight	1.0079
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C9H16O6P2
Molecular Weight	282.1673
Charge	-4
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/24683210 | https://www.ncbi.nlm.nih.gov/pubmed/16237529 | https://www.ncbi.nlm.nih.gov/pubmed/22484715

Incadronate (Disodium Cycloheptylaminomethylene diphosphate) is used to treat malignancy-associated hypercalcemia (MAH) in Japan. Experiments on rodents have revealed that this drug could be an effective agent for the treatment of various arthritic conditions, including human rheumatoid arthritis. In addition was shown, that incadronate induced growth inhibition and apoptotic death of pancreatic cancer cells. Incadronate also inhibited migration presumably by preventing the activation of Rho by lysophosphatidic acid. Thus, this drug can be of value in regimens for the treatment of pancreatic cancer.

Approval Year

PubMed

Title	Date	PubMed
Hydronium (cycloheptylammonio)methylene-1,1-bisphosphonate (hydronium incadronate).	2003 Feb	12574666
Incadronate disodium inhibits joint destruction and periarticular bone loss only in the early phase of rat adjuvant-induced arthritis.	2005	15981025
The protective effects of incadronate on inflammation and joint destruction in established rat adjuvant arthritis.	2006 Jun	16237529
Incadronate induces cell detachment and apoptosis in prostatic PC-3 cells.	2007 Mar-Apr	17465222
Clinical evaluation of incadronate in korean patients with malignancy-associated hypercalcemia: An open-label, multicenter study.	2007 May	24683210

Patents

Sample Use Guides

In Vivo Use Guide

Korean patients with malignancy-associated hypercalcemia (MAH) were given a single 10-mg IV infusion of incadronate over 2 to 4 hours in 500 to 1000 mL of normal saline

Route of Administration: Intravenous

Substance Class	Chemical Created by `admin` on `Sat Dec 16 04:17:13 GMT 2023` Edited by `admin` on `Sat Dec 16 04:17:13 GMT 2023`
Record UNII	7L16W0096A
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

INCADRONATE DISODIUM

Common Name

English

INCADRONATE SODIUM

Common Name

English

Disodium incadronate [WHO-DD]

Common Name

English

PHOSPHONIC ACID, ((CYCLOHEPTYLAMINO)METHYLENE)BIS-, DISODIUM SALT

Common Name

English

PHOSPHONIC ACID, P,P'-((CYCLOHEPTYLAMINO)METHYLENE)BIS-, SODIUM SALT (1:2)

Common Name

English

DISODIUM INCADRONATE

Common Name

English

CIMADRONATE SODIUM

Common Name

English

YM-175

Code

English

BISPHONAL

Brand Name

English

INCADRONIC ACID DISODIUM SALT [MI]

Common Name

English

Code System Code Type Description

SMS_ID

100000078559