Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C9H16O6P2.2Na.H2O |
| Molecular Weight | 346.1621 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | -2 |
SHOW SMILES / InChI
SMILES
O.[Na+].[Na+].[O-]P([O-])(=O)C(CC1CCCCCC1)P([O-])([O-])=O
InChI
InChIKey=OKMIQXBTYKUWOD-UHFFFAOYSA-J
InChI=1S/C9H20O6P2.2Na.H2O/c10-16(11,12)9(17(13,14)15)7-8-5-3-1-2-4-6-8;;;/h8-9H,1-7H2,(H2,10,11,12)(H2,13,14,15);;;1H2/q;2*+1;/p-4
| Molecular Formula | HO |
| Molecular Weight | 17.0073 |
| Charge | -1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C9H19O6P2 |
| Molecular Weight | 285.1911 |
| Charge | -1 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
| Molecular Formula | Na |
| Molecular Weight | 22.98976928 |
| Charge | 1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Incadronate (Disodium Cycloheptylaminomethylene diphosphate) is used to treat malignancy-associated hypercalcemia (MAH) in Japan. Experiments on rodents have revealed that this drug could be an effective agent for the treatment of various arthritic conditions, including human rheumatoid arthritis. In addition was shown, that incadronate induced growth inhibition and apoptotic death of pancreatic cancer cells. Incadronate also inhibited migration presumably by preventing the activation of Rho by lysophosphatidic acid. Thus, this drug can be of value in regimens for the treatment of pancreatic cancer.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Incadronate induces cell detachment and apoptosis in prostatic PC-3 cells. | 2007-05-01 |
|
| Clinical evaluation of incadronate in korean patients with malignancy-associated hypercalcemia: An open-label, multicenter study. | 2007-05 |
|
| The protective effects of incadronate on inflammation and joint destruction in established rat adjuvant arthritis. | 2006-06 |
|
| Incadronate disodium inhibits joint destruction and periarticular bone loss only in the early phase of rat adjuvant-induced arthritis. | 2005 |
|
| Hydronium (cycloheptylammonio)methylene-1,1-bisphosphonate (hydronium incadronate). | 2003-02 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 21:33:45 GMT 2025
by
admin
on
Mon Mar 31 21:33:45 GMT 2025
|
| Record UNII |
6B76RW6OT4
|
| Record Status |
Validated (UNII)
|
| Record Version |
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-
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76957365
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100000172909
Created by
admin on Mon Mar 31 21:33:45 GMT 2025 , Edited by admin on Mon Mar 31 21:33:45 GMT 2025
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6B76RW6OT4
Created by
admin on Mon Mar 31 21:33:45 GMT 2025 , Edited by admin on Mon Mar 31 21:33:45 GMT 2025
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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ANHYDROUS->SOLVATE |
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