OSTABOLIN-C

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 20:25:55 GMT 2025` Edited by `admin` on `Tue Apr 01 20:25:55 GMT 2025`
Protein Type	HORMONE
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	G492NW2HA7
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

OSTABOLIN-C

Common Name

English

L-VALINAMIDE, L-SERYL-L-VALYL-L-SERYL-L-.ALPHA.-GLUTAMYL-L-ISOLEUCYL-L-GLUTAMINYL-L-LEUCYL-L-METHIONYL-L-HISTIDYL-L-ASPARAGINYL-L-LEUCYLGLYCYL-L-LYSYL-L-HISTIDYL-L-LEUCYL-L-ASPARAGINYL-L-SERYL-L-METHIONYL-L-.ALPHA.-GLUTAMYL-L-ARGINYL-L-VALYL-L-.ALPHA.-GL

Preferred Name

English

ZT-031

Code

English

(LEU27)-CYCLO(GLU22-LYS26)-HPTH-(1-31)-NH2

Common Name

English

PTH-1-31 CYCLIC

Code

English

(LEU(SUP 27))CYCLO(GLU(SUP 22)-LYS(SUP 26)-HPTH(1-31)NH2 AMIDE

Common Name

English

Code System Code Type Description

CAS

188899-65-2

Created by admin on Tue Apr 01 20:25:55 GMT 2025 , Edited by admin on Tue Apr 01 20:25:55 GMT 2025

PRIMARY

FDA UNII

G492NW2HA7

Created by admin on Tue Apr 01 20:25:55 GMT 2025 , Edited by admin on Tue Apr 01 20:25:55 GMT 2025

PRIMARY

Linkage Type	Residue Index
AMIDE BOND	1_22	1_26

Related Record Type Details


					7Q6KJ2Q69D

PARATHYROID HORMONE/PARATHYROID HORMONE-RELATED PEPTIDE RECEPTOR

TARGET -> AGONIST

Amount:

Related Record Type Details


					G492NW2HA7

OSTABOLIN-C

ACTIVE MOIETY

Comments:

Class: Osteoporosis therapy, Peptide fragment, Peptide hormone; Mechanism of Action: Osteogenesis stimulant; Highest Development Phases: Discontinued for Osteodystrophy, Osteoporosis, Postmenopausal osteoporosis and Spinal fusion; Most Recent Events: 15 Dec 2011 No development reported - Phase-I for Spinal fusion in Canada (SC), 15 Dec 2011 No development reported - Phase-II for Postmenopausal osteoporosis in Canada (SC)

Amount:

Structural Modifications

Modification Type	Location Site	Residue Modified	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_22]	E	N<sup>6</sup>-L-?-Glutamyl-L-lysine	O19B8F457C
AMINO ACID SUBSTITUTION	[1_26]	K	N<sup>6</sup>-L-?-Glutamyl-L-lysine	O19B8F457C
AMINO ACID SUBSTITUTION	[1_31]	V	VALINAMIDE	JCM10841JE

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:SEQUENCE(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL