MINALRESTAT

Details

Stereochemistry	RACEMIC
Molecular Formula	C19H11BrF2N2O4
Molecular Weight	449.202
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

FC1=CC2=C(C=C1)C(=O)N(CC3=C(F)C=C(Br)C=C3)C(=O)C24CC(=O)NC4=O

InChI

InChIKey=BMHZAHGTGIZZCT-UHFFFAOYSA-N

InChI=1S/C19H11BrF2N2O4/c20-10-2-1-9(14(22)5-10)8-24-16(26)12-4-3-11(21)6-13(12)19(18(24)28)7-15(25)23-17(19)27/h1-6H,7-8H2,(H,23,25,27)

HIDE SMILES / InChI

Molecular Formula	C19H11BrF2N2O4
Molecular Weight	449.202
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/12604701 | https://adisinsight.springer.com/drugs/800003006

Minalrestat was developed by Wyeth-Ayerst as an aldose reductase inhibitor. It is known, the aldose reductase inhibition might ameliorate diabetic complications through the correction of the altered microvascular reactivity by a mechanism that involves NO and membrane hyperpolarization. That is why minalrestat was studied for patients with diabetic retinopathy. However, Wyeth discontinued development of minalrestat.

Originator

Approval Year

PubMed

Title	Date	PubMed
Minalrestat and leukocyte migration in diabetes mellitus.	2003 May-Jun	12789656
Characterization of a rat NADPH-dependent aldo-keto reductase (AKR1B13) induced by oxidative stress.	2009 Mar 16	18845131

Substance Class	Chemical Created by `admin` on `Sat Dec 16 15:54:36 GMT 2023` Edited by `admin` on `Sat Dec 16 15:54:36 GMT 2023`
Record UNII	G44PE6QB31
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MINALRESTAT

Official Name

English

SPIRO(ISOQUINOLINE-4(1H),3'-PYRROLIDINE)-1,2',3,5'(2H)-TETRONE, 2-((4-BROMO-2-FLUOROPHENYL)METHYL)-6-FLUORO-

Systematic Name

English

2-(4-BROMO-2-FLUOROBENZYL)-6-FLUOROSPIRO(ISOQUINOLINE-4(1H),3'-PYRROLIDINE)-1,2',3,5'(2H)-TETRONE

Systematic Name

English

WAY-ARI-509

Code

English

minalrestat [INN]

Common Name

English

MINALRESTAT [USAN]

Common Name

English

Minalrestat [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C72880