U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Wed Apr 02 07:01:02 GMT 2025
Edited
by admin
on Wed Apr 02 07:01:02 GMT 2025
Protein Type MONOCLONAL ANTIBODY
Protein Sub Type IGG4
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
FT24ZQQ5RP
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
OMS-721
Preferred Name English
NARSOPLIMAB
USAN   INN  
Official Name English
ANTI-MASP-2 MONOCLONAL ANTIBODY OMS721
Common Name English
Narsoplimab [WHO-DD]
Common Name English
IMMUNOGLOBULIN G4-LAMBDA, ANTI-(HOMO SAPIENS MANNAN-BINDING LECTIN SERINE PROTEASE 2 (MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASE 2, EC=3.4.21.104) HUMAN MONOCLONAL ANTIBODY .GAMMA.4 HEAVY CHAIN (1-445) (HOMO SAPIENS VH (IGHV2-26*01 (94%) (IGHD)-I
Common Name English
IMMUNOGLOBULIN G4 (226-PROLINE), ANTI-(HUMAN MANNAN-BINDING LECTIN-ASSOCIATED SERINE PROTEASE 2) (HUMAN MONOCLONAL OMS721 .GAMMA.4-CHAIN), DISULFIDE WITH HUMAN MONOCLONAL OMS721 .LAMBDA.-CHAIN, DIMER
Common Name English
narsoplimab [INN]
Common Name English
OMS00620646
Code English
MASP-2 ANTIBODY
Common Name English
NARSOPLIMAB [USAN]
Common Name English
OMS620646
Code English
OMS721
Code English
Classification Tree Code System Code
FDA ORPHAN DRUG 655418
Created by admin on Wed Apr 02 07:01:02 GMT 2025 , Edited by admin on Wed Apr 02 07:01:02 GMT 2025
FDA ORPHAN DRUG 397813
Created by admin on Wed Apr 02 07:01:02 GMT 2025 , Edited by admin on Wed Apr 02 07:01:02 GMT 2025
FDA ORPHAN DRUG 561516
Created by admin on Wed Apr 02 07:01:02 GMT 2025 , Edited by admin on Wed Apr 02 07:01:02 GMT 2025
Code System Code Type Description
USAN
FG-185
Created by admin on Wed Apr 02 07:01:02 GMT 2025 , Edited by admin on Wed Apr 02 07:01:02 GMT 2025
PRIMARY
NCI_THESAURUS
C119952
Created by admin on Wed Apr 02 07:01:02 GMT 2025 , Edited by admin on Wed Apr 02 07:01:02 GMT 2025
PRIMARY
SMS_ID
100000181005
Created by admin on Wed Apr 02 07:01:02 GMT 2025 , Edited by admin on Wed Apr 02 07:01:02 GMT 2025
PRIMARY
FDA UNII
FT24ZQQ5RP
Created by admin on Wed Apr 02 07:01:02 GMT 2025 , Edited by admin on Wed Apr 02 07:01:02 GMT 2025
PRIMARY
CAS
2108782-45-0
Created by admin on Wed Apr 02 07:01:02 GMT 2025 , Edited by admin on Wed Apr 02 07:01:02 GMT 2025
PRIMARY
INN
11174
Created by admin on Wed Apr 02 07:01:02 GMT 2025 , Edited by admin on Wed Apr 02 07:01:02 GMT 2025
PRIMARY
From To
1_22 1_97
2_22 2_97
2_132 4_211
2_145 2_201
2_259 2_319
1_132 3_211
2_365 2_423
3_22 3_87
3_134 3_193
4_22 4_87
4_134 4_193
1_145 1_201
1_224 2_224
1_227 2_227
1_259 1_319
1_365 1_423
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_295
N 2_295
Related Record Type Details
MANNAN-BINDING LECTIN SERINE PROTEASE 2
TARGET -> INHIBITOR
Related Record Type Details
NARSOPLIMAB
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
amino acid substitution [1_1] [2_1] Gln PIDOLIC ACID SZB83O1W42
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
Molecular Formula CHEMICAL
NIH
NCATS
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