Details
Stereochemistry | RACEMIC |
Molecular Formula | C11H12I3NO2 |
Molecular Weight | 570.9319 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCC(CC1=C(I)C(N)=C(I)C=C1I)C(O)=O
InChI
InChIKey=OIRFJRBSRORBCM-UHFFFAOYSA-N
InChI=1S/C11H12I3NO2/c1-2-5(11(16)17)3-6-7(12)4-8(13)10(15)9(6)14/h4-5H,2-3,15H2,1H3,(H,16,17)
Molecular Formula | C11H12I3NO2 |
Molecular Weight | 570.9319 |
Charge | 0 |
Count |
|
Stereochemistry | RACEMIC |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Optical Activity | ( + / - ) |
Originator
Sources: http://www.springer.com/kr/book/9783642695179
Curator's Comment: M. Sovak. Radiocontrast Agents. (1984), p. 383. ISBN13: 9783642695179
Approval Year
Doses
Dose | Population | Adverse events |
---|---|---|
75 g single, oral Overdose |
unknown, 42 years n = 1 Health Status: unknown Condition: used for diagnosis Age Group: 42 years Sex: M Population Size: 1 Sources: |
Disc. AE: Diarrhea... AEs leading to discontinuation/dose reduction: Diarrhea (1 patient) Sources: |
3 g single, oral Recommended |
unknown, adult n = 48 Health Status: unknown Condition: used for diagnosis Age Group: adult Sex: unknown Population Size: 48 Sources: |
Other AEs: Gastrointestinal disorders... |
AEs
AE | Significance | Dose | Population |
---|---|---|---|
Diarrhea | 1 patient Disc. AE |
75 g single, oral Overdose |
unknown, 42 years n = 1 Health Status: unknown Condition: used for diagnosis Age Group: 42 years Sex: M Population Size: 1 Sources: |
Gastrointestinal disorders | 39 patients | 3 g single, oral Recommended |
unknown, adult n = 48 Health Status: unknown Condition: used for diagnosis Age Group: adult Sex: unknown Population Size: 48 Sources: |
PubMed
Title | Date | PubMed |
---|---|---|
Additive nephrotoxicity from roentgenographic contrast media. Its occurrence in phenazopyridine-induced acute renal failure. | 1981 May |
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Are the effects of T3 on resting metabolic rate in euthyroid rats entirely caused by T3 itself? | 2002 Feb |
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Acute decrease in circulating T3 levels enhances, but does not normalise, the GH response to GHRP-6 plus GHRH in thyrotoxicosis. | 2003 Aug |
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Perioperative management of the thyrotoxic patient. | 2003 Jun |
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Convective distribution of macromolecules in the primate brain demonstrated using computerized tomography and magnetic resonance imaging. | 2003 Mar |
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Light-induced hormone conversion of T4 to T3 regulates photoperiodic response of gonads in birds. | 2003 Nov 13 |
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Is there a place for thyroidectomy in older patients with thyrotoxic storm and cardiorespiratory failure? | 2003 Oct |
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Inhibition of drug binding to human serum albumin by cholecystographic agents. | 2003 Sep |
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Thyroid hormones interact with glucocorticoids to affect somatotroph abundance in chicken embryonic pituitary cells in vitro. | 2003 Sep |
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Iopanoic acid in the management of neonatal Graves' disease. | 2004 Feb |
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Expression of type II iodothyronine deiodinase marks the time that a tissue responds to thyroid hormone-induced metamorphosis in Xenopus laevis. | 2004 Feb 1 |
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Rapid preparation of severe uncontrolled thyrotoxicosis due to Graves' disease with Iopanoic acid--a case report. | 2004 Jan |
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Rapid preoperative preparation for severe hyperthyroid Graves' disease. | 2004 May |
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Effect of iopanoic acid on radioiodine therapy of hyperthyroidism: long-term outcome of a randomized controlled trial. | 2005 Dec |
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Thin-section multiplanar reformats from multidetector-row CT data: utility for assessment of regional tumor extent in non-small cell lung cancer. | 2005 Oct |
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Long-lasting systemic bait markers for Eurasian badgers. | 2006 Oct |
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An in vivo multiwell-based fluorescent screen for monitoring vertebrate thyroid hormone disruption. | 2007 Aug 15 |
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Combination of minimally invasive thyroid surgery and local anesthesia associated to iopanoic acid for patients with amiodarone-induced thyrotoxicosis and severe cardiac disorders: a pilot study. | 2007 Nov |
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A fatal case of recurrent amiodarone-induced thyrotoxicosis after percutaneous tracheotomy: a case report. | 2007 Nov 13 |
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Crystallographic analysis of human serum albumin complexed with 4Z,15E-bilirubin-IXalpha. | 2008 Aug 29 |
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Pharmacodynamic effect of iopanoic acid on free T(3) and T(4) levels in amiodarone-induced thyrotoxicosis. | 2008 Dec |
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Structural basis of GC-1 selectivity for thyroid hormone receptor isoforms. | 2008 Jan 31 |
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Vaccination of feral pigs (Sus scrofa) using iophenoxic acid as a simulated vaccine. | 2008 Jan-Feb |
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Competitive inhibition of organic anion transporting polypeptide 1c1-mediated thyroxine transport by the fenamate class of nonsteroidal antiinflammatory drugs. | 2009 Feb |
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Effects and safety of iopanoic acid in cats administered levothyroxine. | 2009 Feb |
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Anesthetic considerations in a patient with amiodarone-induced thyrotoxicosis. | 2010 |
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Autoimmune thyroid diseases in children. | 2010 Dec 14 |
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Analysis by LC/ESI-MS of iophenoxic acid derivatives and evaluation as markers of oral baits to deliver pharmaceuticals to wildlife. | 2010 Jul 15 |
|
Monitoring of deiodinase deficiency based on transcriptomic responses in SH-SY5Y cells. | 2013 Jun |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1304283
Take 500 mg orally twice a day for the first 3 weeks.
Route of Administration:
Oral
Substance Class |
Chemical
Created
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Record UNII |
FE9794P71J
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Validated (UNII)
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Classification Tree | Code System | Code | ||
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WHO-VATC |
QV08AC06
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WHO-ATC |
V08AC06
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NCI_THESAURUS |
C28500
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Code System | Code | Type | Description | ||
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3
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41706
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5967
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3735
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3345
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FE9794P71J
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100000083105
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IOPANOIC ACID
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PRIMARY | Description: A light yellowish white powder; odour, faint, characteristic. Solubility: Practically insoluble in water; soluble in ethanol (~750 g/l) TS, and acetone R; dissolves in solutions of alkali hydroxides. Category: Radiocontrast medium. Storage: Iopanoic acid should be kept in a tightly closed container, protected from light. Iopanoic acid is gradually affected by light. Requirements: Iopanoic acid contains not less than 97.0% and not more than the equivalent of 101.0% of C11H12I3NO2, calculated with reference to the dried substance. | ||
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SUB08240MIG
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637485
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202-539-9
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DB08946
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m6371
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PRIMARY | Merck Index | ||
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17879-93-5
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SUPERSEDED | |||
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Iopanoic acid
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96-83-3
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DTXSID6023159
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CHEMBL867
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C65942
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1465
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D007480
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PRIMARY |
Related Record | Type | Details | ||
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SALT/SOLVATE -> PARENT | |||
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ENANTIOMER -> RACEMATE | |||
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ENANTIOMER -> RACEMATE |
Related Record | Type | Details | ||
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ACTIVE MOIETY |