Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C11H12I3NO2 |
| Molecular Weight | 570.9319 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCC(CC1=C(I)C(N)=C(I)C=C1I)C(O)=O
InChI
InChIKey=OIRFJRBSRORBCM-UHFFFAOYSA-N
InChI=1S/C11H12I3NO2/c1-2-5(11(16)17)3-6-7(12)4-8(13)10(15)9(6)14/h4-5H,2-3,15H2,1H3,(H,16,17)
| Molecular Formula | C11H12I3NO2 |
| Molecular Weight | 570.9319 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
Approval Year
Doses
| Dose | Population | Adverse events |
|---|---|---|
75 g single, oral Overdose |
unknown, 42 years n = 1 Health Status: unknown Condition: used for diagnosis Age Group: 42 years Sex: M Population Size: 1 Sources: |
Disc. AE: Diarrhea... AEs leading to discontinuation/dose reduction: Diarrhea (1 patient) Sources: |
3 g single, oral Recommended |
unknown, adult n = 48 Health Status: unknown Condition: used for diagnosis Age Group: adult Sex: unknown Population Size: 48 Sources: |
Other AEs: Gastrointestinal disorders... |
AEs
| AE | Significance | Dose | Population |
|---|---|---|---|
| Diarrhea | 1 patient Disc. AE |
75 g single, oral Overdose |
unknown, 42 years n = 1 Health Status: unknown Condition: used for diagnosis Age Group: 42 years Sex: M Population Size: 1 Sources: |
| Gastrointestinal disorders | 39 patients | 3 g single, oral Recommended |
unknown, adult n = 48 Health Status: unknown Condition: used for diagnosis Age Group: adult Sex: unknown Population Size: 48 Sources: |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Additive nephrotoxicity from roentgenographic contrast media. Its occurrence in phenazopyridine-induced acute renal failure. | 1981 May |
|
| The activity of antioxidant enzymes and the content of uncoupling protein-1 in the brown adipose tissue of hypothyroid rats: comparison with effects of iopanoic acid. | 2001 |
|
| A test of the hypothesis that T3 is the "seasonality" thyroid hormone in American tree sparrows (Spizella arborea): intracerebroventricular infusion of iopanoic acid, an inhibitor of T3 synthesis and degradation. | 2001 Mar |
|
| Clinical review 129: Oral cholecystographic agents and the thyroid. | 2001 May |
|
| Preparation with iopanoic acid rapidly controls thyrotoxicosis in patients with amiodarone-induced thyrotoxicosis before thyroidectomy. | 2002 Dec |
|
| Are the effects of T3 on resting metabolic rate in euthyroid rats entirely caused by T3 itself? | 2002 Feb |
|
| Recombinant lysine:N(6)-hydroxylase: effect of cysteine-->alanine replacements on structural integrity and catalytic competence. | 2002 Feb 11 |
|
| Use of oral cholecystography agents in the treatment of hyperthyroidism of subacute thyroiditis. | 2003 Mar |
|
| Light-induced hormone conversion of T4 to T3 regulates photoperiodic response of gonads in birds. | 2003 Nov 13 |
|
| [Levothyroxine poisoning: clinical manifestations and therapeutic management]. | 2004 Jan |
|
| Thyroid (dys)function in heart failure: is it a potential target for medical treatment? | 2005 |
|
| Effect of iopanoic acid on radioiodine therapy of hyperthyroidism: long-term outcome of a randomized controlled trial. | 2005 Dec |
|
| Thin-section multiplanar reformats from multidetector-row CT data: utility for assessment of regional tumor extent in non-small cell lung cancer. | 2005 Oct |
|
| Comparison of enhancing effects of different goitrogen treatments in combination with beta-estradiol-3-benzoate for establishing a rat two-stage thyroid carcinogenesis model to detect modifying effects of estrogenic compounds. | 2006 Jan |
|
| An in vivo multiwell-based fluorescent screen for monitoring vertebrate thyroid hormone disruption. | 2007 Aug 15 |
|
| Hashimoto's thyroiditis and the role of selenium. Current concepts. | 2007 Jan-Apr |
|
| Combination of minimally invasive thyroid surgery and local anesthesia associated to iopanoic acid for patients with amiodarone-induced thyrotoxicosis and severe cardiac disorders: a pilot study. | 2007 Nov |
|
| A fatal case of recurrent amiodarone-induced thyrotoxicosis after percutaneous tracheotomy: a case report. | 2007 Nov 13 |
|
| Morphological and biochemical changes in the Harderian gland of hypothyroid rats. | 2008 Feb |
|
| Structural basis of GC-1 selectivity for thyroid hormone receptor isoforms. | 2008 Jan 31 |
|
| Amiodarone-induced thyrotoxicosis. A review. | 2008 Sep |
|
| Effects of different treatments for hyperthyroidism on the hypothalamic-pituitary-adrenal axis. | 2008 Sep |
|
| Autoimmune thyroid diseases in children. | 2010 Dec 14 |
|
| Analysis by LC/ESI-MS of iophenoxic acid derivatives and evaluation as markers of oral baits to deliver pharmaceuticals to wildlife. | 2010 Jul 15 |
|
| Identification of iopanoic acid as substrate of type 1 deiodinase by a novel nonradioactive iodide-release assay. | 2012 May |
|
| Monitoring of deiodinase deficiency based on transcriptomic responses in SH-SY5Y cells. | 2013 Jun |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 16:42:39 GMT 2023
by
admin
on
Sat Dec 16 16:42:39 GMT 2023
|
| Record UNII |
FE9794P71J
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Official Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Brand Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Brand Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
|
WHO-VATC |
QV08AC06
Created by
admin on Sat Dec 16 16:42:39 GMT 2023 , Edited by admin on Sat Dec 16 16:42:39 GMT 2023
|
||
|
WHO-ATC |
V08AC06
Created by
admin on Sat Dec 16 16:42:39 GMT 2023 , Edited by admin on Sat Dec 16 16:42:39 GMT 2023
|
||
|
NCI_THESAURUS |
C28500
Created by
admin on Sat Dec 16 16:42:39 GMT 2023 , Edited by admin on Sat Dec 16 16:42:39 GMT 2023
|
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
3
Created by
admin on Sat Dec 16 16:42:39 GMT 2023 , Edited by admin on Sat Dec 16 16:42:39 GMT 2023
|
PRIMARY | |||
|
41706
Created by
admin on Sat Dec 16 16:42:39 GMT 2023 , Edited by admin on Sat Dec 16 16:42:39 GMT 2023
|
PRIMARY | |||
|
5967
Created by
admin on Sat Dec 16 16:42:39 GMT 2023 , Edited by admin on Sat Dec 16 16:42:39 GMT 2023
|
PRIMARY | |||
|
3735
Created by
admin on Sat Dec 16 16:42:39 GMT 2023 , Edited by admin on Sat Dec 16 16:42:39 GMT 2023
|
PRIMARY | |||
|
3345
Created by
admin on Sat Dec 16 16:42:39 GMT 2023 , Edited by admin on Sat Dec 16 16:42:39 GMT 2023
|
PRIMARY | |||
|
FE9794P71J
Created by
admin on Sat Dec 16 16:42:39 GMT 2023 , Edited by admin on Sat Dec 16 16:42:39 GMT 2023
|
PRIMARY | |||
|
100000083105
Created by
admin on Sat Dec 16 16:42:39 GMT 2023 , Edited by admin on Sat Dec 16 16:42:39 GMT 2023
|
PRIMARY | |||
|
IOPANOIC ACID
Created by
admin on Sat Dec 16 16:42:39 GMT 2023 , Edited by admin on Sat Dec 16 16:42:39 GMT 2023
|
PRIMARY | Description: A light yellowish white powder; odour, faint, characteristic. Solubility: Practically insoluble in water; soluble in ethanol (~750 g/l) TS, and acetone R; dissolves in solutions of alkali hydroxides. Category: Radiocontrast medium. Storage: Iopanoic acid should be kept in a tightly closed container, protected from light. Iopanoic acid is gradually affected by light. Requirements: Iopanoic acid contains not less than 97.0% and not more than the equivalent of 101.0% of C11H12I3NO2, calculated with reference to the dried substance. | ||
|
SUB08240MIG
Created by
admin on Sat Dec 16 16:42:39 GMT 2023 , Edited by admin on Sat Dec 16 16:42:39 GMT 2023
|
PRIMARY | |||
|
637485
Created by
admin on Sat Dec 16 16:42:39 GMT 2023 , Edited by admin on Sat Dec 16 16:42:39 GMT 2023
|
ALTERNATIVE | |||
|
202-539-9
Created by
admin on Sat Dec 16 16:42:39 GMT 2023 , Edited by admin on Sat Dec 16 16:42:39 GMT 2023
|
PRIMARY | |||
|
DB08946
Created by
admin on Sat Dec 16 16:42:39 GMT 2023 , Edited by admin on Sat Dec 16 16:42:39 GMT 2023
|
PRIMARY | |||
|
m6371
Created by
admin on Sat Dec 16 16:42:39 GMT 2023 , Edited by admin on Sat Dec 16 16:42:39 GMT 2023
|
PRIMARY | Merck Index | ||
|
17879-93-5
Created by
admin on Sat Dec 16 16:42:39 GMT 2023 , Edited by admin on Sat Dec 16 16:42:39 GMT 2023
|
SUPERSEDED | |||
|
Iopanoic acid
Created by
admin on Sat Dec 16 16:42:39 GMT 2023 , Edited by admin on Sat Dec 16 16:42:39 GMT 2023
|
PRIMARY | |||
|
96-83-3
Created by
admin on Sat Dec 16 16:42:39 GMT 2023 , Edited by admin on Sat Dec 16 16:42:39 GMT 2023
|
PRIMARY | |||
|
DTXSID6023159
Created by
admin on Sat Dec 16 16:42:39 GMT 2023 , Edited by admin on Sat Dec 16 16:42:39 GMT 2023
|
PRIMARY | |||
|
CHEMBL867
Created by
admin on Sat Dec 16 16:42:39 GMT 2023 , Edited by admin on Sat Dec 16 16:42:39 GMT 2023
|
PRIMARY | |||
|
C65942
Created by
admin on Sat Dec 16 16:42:39 GMT 2023 , Edited by admin on Sat Dec 16 16:42:39 GMT 2023
|
PRIMARY | |||
|
1465
Created by
admin on Sat Dec 16 16:42:39 GMT 2023 , Edited by admin on Sat Dec 16 16:42:39 GMT 2023
|
PRIMARY | |||
|
D007480
Created by
admin on Sat Dec 16 16:42:39 GMT 2023 , Edited by admin on Sat Dec 16 16:42:39 GMT 2023
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
SALT/SOLVATE -> PARENT | |||
|
|
ENANTIOMER -> RACEMATE | |||
|
|
ENANTIOMER -> RACEMATE |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
ACTIVE MOIETY |
