Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C11H11I3NO2.Na |
| Molecular Weight | 592.9137 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].CCC(CC1=C(I)C(N)=C(I)C=C1I)C([O-])=O
InChI
InChIKey=LEXZDSSHLHPSQC-UHFFFAOYSA-M
InChI=1S/C11H12I3NO2.Na/c1-2-5(11(16)17)3-6-7(12)4-8(13)10(15)9(6)14;/h4-5H,2-3,15H2,1H3,(H,16,17);/q;+1/p-1
| Molecular Formula | C11H11I3NO2 |
| Molecular Weight | 569.924 |
| Charge | -1 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
| Molecular Formula | Na |
| Molecular Weight | 22.9898 |
| Charge | 1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
Doses
| Dose | Population | Adverse events |
|---|---|---|
75 g single, oral Overdose |
unknown, 42 years n = 1 Health Status: unknown Condition: used for diagnosis Age Group: 42 years Sex: M Population Size: 1 Sources: |
Disc. AE: Diarrhea... AEs leading to discontinuation/dose reduction: Diarrhea (1 patient) Sources: |
3 g single, oral Recommended |
unknown, adult n = 48 Health Status: unknown Condition: used for diagnosis Age Group: adult Sex: unknown Population Size: 48 Sources: |
Other AEs: Gastrointestinal disorders... |
AEs
| AE | Significance | Dose | Population |
|---|---|---|---|
| Diarrhea | 1 patient Disc. AE |
75 g single, oral Overdose |
unknown, 42 years n = 1 Health Status: unknown Condition: used for diagnosis Age Group: 42 years Sex: M Population Size: 1 Sources: |
| Gastrointestinal disorders | 39 patients | 3 g single, oral Recommended |
unknown, adult n = 48 Health Status: unknown Condition: used for diagnosis Age Group: adult Sex: unknown Population Size: 48 Sources: |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Additive nephrotoxicity from roentgenographic contrast media. Its occurrence in phenazopyridine-induced acute renal failure. | 1981 May |
|
| A test of the hypothesis that T3 is the "seasonality" thyroid hormone in American tree sparrows (Spizella arborea): intracerebroventricular infusion of iopanoic acid, an inhibitor of T3 synthesis and degradation. | 2001 Mar |
|
| A surface-modified chylomicron remnant-like emulsion for percutaneous computed tomography lymphography: synthesis and preliminary imaging findings. | 2002 Apr |
|
| Perioperative management of the thyrotoxic patient. | 2003 Jun |
|
| Treatment of type II amiodarone-induced thyrotoxicosis by either iopanoic acid or glucocorticoids: a prospective, randomized study. | 2003 May |
|
| Is there a place for thyroidectomy in older patients with thyrotoxic storm and cardiorespiratory failure? | 2003 Oct |
|
| Inhibition of drug binding to human serum albumin by cholecystographic agents. | 2003 Sep |
|
| Thyroid hormones interact with glucocorticoids to affect somatotroph abundance in chicken embryonic pituitary cells in vitro. | 2003 Sep |
|
| Treatment of hyperthyroidism associated with thyrotropin-secreting pituitary adenomas with iopanoic acid. | 2004 Feb |
|
| Iopanoic acid in the management of neonatal Graves' disease. | 2004 Feb |
|
| Expression of type II iodothyronine deiodinase marks the time that a tissue responds to thyroid hormone-induced metamorphosis in Xenopus laevis. | 2004 Feb 1 |
|
| Oral contrast-enhanced CT cholangiography--an initial experience. | 2004 Jan |
|
| Percutaneous transcholecystic biliary interventions using gallbladder anchors: feasibility study in the swine. | 2005 Jul-Aug |
|
| Unliganded thyroid hormone receptor is essential for Xenopus laevis eye development. | 2006 Oct 18 |
|
| An in vivo multiwell-based fluorescent screen for monitoring vertebrate thyroid hormone disruption. | 2007 Aug 15 |
|
| A fatal case of recurrent amiodarone-induced thyrotoxicosis after percutaneous tracheotomy: a case report. | 2007 Nov 13 |
|
| Pharmacodynamic effect of iopanoic acid on free T(3) and T(4) levels in amiodarone-induced thyrotoxicosis. | 2008 Dec |
|
| [Rapid preoperative preparation with iopanoic acid in severe liver toxicity due to methimazole: anesthetic implications]. | 2008 Feb |
|
| Morphological and biochemical changes in the Harderian gland of hypothyroid rats. | 2008 Feb |
|
| Structural basis of GC-1 selectivity for thyroid hormone receptor isoforms. | 2008 Jan 31 |
|
| Vaccination of feral pigs (Sus scrofa) using iophenoxic acid as a simulated vaccine. | 2008 Jan-Feb |
|
| Amiodarone-induced thyrotoxicosis. A review. | 2008 Sep |
|
| Competitive inhibition of organic anion transporting polypeptide 1c1-mediated thyroxine transport by the fenamate class of nonsteroidal antiinflammatory drugs. | 2009 Feb |
|
| Anesthetic considerations in a patient with amiodarone-induced thyrotoxicosis. | 2010 |
|
| Analysis by LC/ESI-MS of iophenoxic acid derivatives and evaluation as markers of oral baits to deliver pharmaceuticals to wildlife. | 2010 Jul 15 |
|
| Monitoring of deiodinase deficiency based on transcriptomic responses in SH-SY5Y cells. | 2013 Jun |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 10:04:20 GMT 2023
by
admin
on
Sat Dec 16 10:04:20 GMT 2023
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| Record UNII |
439WET4G58
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| Record Status |
Validated (UNII)
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| Record Version |
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219-683-3
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m6371
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SUB02750MIG
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439WET4G58
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23669441
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340398
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DTXSID20947842
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100000086410
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138711-85-0
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2497-78-1
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PARENT -> SALT/SOLVATE |
