Details
Stereochemistry | RACEMIC |
Molecular Formula | C11H11I3NO2.Na |
Molecular Weight | 592.9137 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].CCC(CC1=C(I)C(N)=C(I)C=C1I)C([O-])=O
InChI
InChIKey=LEXZDSSHLHPSQC-UHFFFAOYSA-M
InChI=1S/C11H12I3NO2.Na/c1-2-5(11(16)17)3-6-7(12)4-8(13)10(15)9(6)14;/h4-5H,2-3,15H2,1H3,(H,16,17);/q;+1/p-1
Molecular Formula | C11H11I3NO2 |
Molecular Weight | 569.924 |
Charge | -1 |
Count |
|
Stereochemistry | RACEMIC |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Optical Activity | ( + / - ) |
Molecular Formula | Na |
Molecular Weight | 22.9898 |
Charge | 1 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Originator
Sources: http://www.springer.com/kr/book/9783642695179
Curator's Comment: M. Sovak. Radiocontrast Agents. (1984), p. 383. ISBN13: 9783642695179
Approval Year
Doses
Dose | Population | Adverse events |
---|---|---|
75 g single, oral Overdose |
unknown, 42 years n = 1 Health Status: unknown Condition: used for diagnosis Age Group: 42 years Sex: M Population Size: 1 Sources: |
Disc. AE: Diarrhea... AEs leading to discontinuation/dose reduction: Diarrhea (1 patient) Sources: |
3 g single, oral Recommended |
unknown, adult n = 48 Health Status: unknown Condition: used for diagnosis Age Group: adult Sex: unknown Population Size: 48 Sources: |
Other AEs: Gastrointestinal disorders... |
AEs
AE | Significance | Dose | Population |
---|---|---|---|
Diarrhea | 1 patient Disc. AE |
75 g single, oral Overdose |
unknown, 42 years n = 1 Health Status: unknown Condition: used for diagnosis Age Group: 42 years Sex: M Population Size: 1 Sources: |
Gastrointestinal disorders | 39 patients | 3 g single, oral Recommended |
unknown, adult n = 48 Health Status: unknown Condition: used for diagnosis Age Group: adult Sex: unknown Population Size: 48 Sources: |
PubMed
Title | Date | PubMed |
---|---|---|
Additive nephrotoxicity from roentgenographic contrast media. Its occurrence in phenazopyridine-induced acute renal failure. | 1981 May |
|
The activity of antioxidant enzymes and the content of uncoupling protein-1 in the brown adipose tissue of hypothyroid rats: comparison with effects of iopanoic acid. | 2001 |
|
A test of the hypothesis that T3 is the "seasonality" thyroid hormone in American tree sparrows (Spizella arborea): intracerebroventricular infusion of iopanoic acid, an inhibitor of T3 synthesis and degradation. | 2001 Mar |
|
Preparation with iopanoic acid rapidly controls thyrotoxicosis in patients with amiodarone-induced thyrotoxicosis before thyroidectomy. | 2002 Dec |
|
Are the effects of T3 on resting metabolic rate in euthyroid rats entirely caused by T3 itself? | 2002 Feb |
|
Recombinant lysine:N(6)-hydroxylase: effect of cysteine-->alanine replacements on structural integrity and catalytic competence. | 2002 Feb 11 |
|
Effect of iodine or iopanoic acid on thyroid Ca2+/NADPH-dependent H2O2-generating activity and thyroperoxidase in toxic diffuse goiters. | 2002 Sep |
|
Acute decrease in circulating T3 levels enhances, but does not normalise, the GH response to GHRP-6 plus GHRH in thyrotoxicosis. | 2003 Aug |
|
Convective distribution of macromolecules in the primate brain demonstrated using computerized tomography and magnetic resonance imaging. | 2003 Mar |
|
Light-induced hormone conversion of T4 to T3 regulates photoperiodic response of gonads in birds. | 2003 Nov 13 |
|
Inhibition of drug binding to human serum albumin by cholecystographic agents. | 2003 Sep |
|
Thyroid hormones interact with glucocorticoids to affect somatotroph abundance in chicken embryonic pituitary cells in vitro. | 2003 Sep |
|
Thyroid hormone-dependent seasonality in American tree sparrows (Spizella arborea): effects of GC-1, a thyroid receptor beta-selective agonist, and of iopanoic acid, a deiodinase inhibitor. | 2004 Aug |
|
Iopanoic acid in the management of neonatal Graves' disease. | 2004 Feb |
|
Expression of type II iodothyronine deiodinase marks the time that a tissue responds to thyroid hormone-induced metamorphosis in Xenopus laevis. | 2004 Feb 1 |
|
Rapid preoperative preparation for severe hyperthyroid Graves' disease. | 2004 May |
|
Thyroid (dys)function in heart failure: is it a potential target for medical treatment? | 2005 |
|
Effects of tetraiodothyronine and triiodothyronine on hamster cheek pouch microcirculation. | 2005 Apr |
|
Thin-section multiplanar reformats from multidetector-row CT data: utility for assessment of regional tumor extent in non-small cell lung cancer. | 2005 Oct |
|
Liquid chromatography-electrospray ionization mass spectrometry for direct identification and quantification of iophenoxic acid in serum. | 2006 Feb 17 |
|
Comparison of enhancing effects of different goitrogen treatments in combination with beta-estradiol-3-benzoate for establishing a rat two-stage thyroid carcinogenesis model to detect modifying effects of estrogenic compounds. | 2006 Jan |
|
Long-lasting systemic bait markers for Eurasian badgers. | 2006 Oct |
|
Hashimoto's thyroiditis and the role of selenium. Current concepts. | 2007 Jan-Apr |
|
Structural basis of GC-1 selectivity for thyroid hormone receptor isoforms. | 2008 Jan 31 |
|
Amiodarone-induced thyrotoxicosis. A review. | 2008 Sep |
|
Monitoring of deiodinase deficiency based on transcriptomic responses in SH-SY5Y cells. | 2013 Jun |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1304283
Take 500 mg orally twice a day for the first 3 weeks.
Route of Administration:
Oral
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 10:04:20 UTC 2023
by
admin
on
Sat Dec 16 10:04:20 UTC 2023
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Record UNII |
439WET4G58
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Record Status |
Validated (UNII)
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219-683-3
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m6371
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23669441
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340398
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138711-85-0
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2497-78-1
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