Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C44H70O22 |
Molecular Weight | 951.0134 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 26 / 26 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12CC[C@@]3(C[C@]1(CC3=C)CC[C@]4([H])[C@@](C)(CCC[C@@]24C)C(=O)O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O[C@@H]7O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O)[C@H]6O[C@@H]8O[C@@H](C)[C@H](O)[C@@H](O)[C@H]8O
InChI
InChIKey=QSRAJVGDWKFOGU-WBXIDTKBSA-N
InChI=1S/C44H70O22/c1-17-12-43-10-6-22-41(3,8-5-9-42(22,4)40(58)65-38-33(57)30(54)26(50)20(14-46)61-38)23(43)7-11-44(17,16-43)66-39-35(64-36-31(55)28(52)24(48)18(2)59-36)34(27(51)21(15-47)62-39)63-37-32(56)29(53)25(49)19(13-45)60-37/h18-39,45-57H,1,5-16H2,2-4H3/t18-,19+,20+,21+,22-,23-,24-,25+,26+,27+,28+,29-,30-,31+,32+,33+,34-,35+,36-,37-,38-,39-,41+,42+,43+,44-/m0/s1
Molecular Formula | C44H70O22 |
Molecular Weight | 951.0134 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 26 / 26 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/27784241Curator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/23203115 | https://www.ncbi.nlm.nih.gov/pubmed/28228527 | https://www.ncbi.nlm.nih.gov/pubmed/24783855 | https://www.ncbi.nlm.nih.gov/pubmed/12419967
Sources: https://www.ncbi.nlm.nih.gov/pubmed/27784241
Curator's Comment: The description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/23203115 | https://www.ncbi.nlm.nih.gov/pubmed/28228527 | https://www.ncbi.nlm.nih.gov/pubmed/24783855 | https://www.ncbi.nlm.nih.gov/pubmed/12419967
Rebaudioside C is a natural primary glycoside constituent of the plant Stevia rebaudiana Bertoni and used as natural non-caloric sweeteners to diabetics and others on carbohydrate-controlled diets. Found in the by-product of Rebaudioside A production, Rebaudioside C is produced through advanced glycoside isolation and specialized extraction processing. While not a sweetener itself, Rebaudioside C has been trialed with nutritive sweeteners and shown to enable a 20-25% reduction in calories. In preclinical studies Rebaudioside C shows potent anti-inflammatory activity in against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice. Steviol glycosides have not yet been approved as a sweetener in the European Union, but purified rebaudioside A gained GRAS (Generally Recognized as Safe) status in the USA in 2008, and in the same year the Joint FAO/WHO Expert Committee on Food Additives suggested a temporary admissible daily intake (ADI) of 0–4 mg/kg body weight, expressed as steviol.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: GO:1903767 Sources: https://www.ncbi.nlm.nih.gov/pubmed/21337478 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Unknown Approved UseUnknown |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/12419967
Mice were treated with Rebaudioside C (200mg/ear
Route of Administration:
Topical
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/16448183
The PC12 cells were used for activity evaluation. Cell viability was measured by trypan blue exclusion assay. The PC12 cells were incubated in DMEM containing serum with 0 to 10,000 ng/mL stevioside for 72 h. After the incubation, cells were stained in 0.25% trypan blue solution in phosphate-buffered saline. Total cells and trypan blue-stained cells were counted using a hemocytometer. Cell viability was expressed as a percentage against the total cell number in each experiment.
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:23:55 GMT 2023
by
admin
on
Sat Dec 16 08:23:55 GMT 2023
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Record UNII |
FE0M8Z5L2E
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Record Status |
Validated (UNII)
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Related Record | Type | Details | ||
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PARENT -> CONSTITUENT ALWAYS PRESENT |
Isolated stevia sweetener, produced by the extraction of STEVIA REBAUDIANA leaves by hot water and powdering.
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