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Details

Stereochemistry RACEMIC
Molecular Formula C17H25N3O
Molecular Weight 287.3999
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PROXAZOLE

SMILES

CCC(C1=NOC(CCN(CC)CC)=N1)C2=CC=CC=C2

InChI

InChIKey=OLTAWOVKGWWERU-UHFFFAOYSA-N
InChI=1S/C17H25N3O/c1-4-15(14-10-8-7-9-11-14)17-18-16(21-19-17)12-13-20(5-2)6-3/h7-11,15H,4-6,12-13H2,1-3H3

HIDE SMILES / InChI

Molecular Formula C17H25N3O
Molecular Weight 287.3999
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description
Curator's Comment: description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/5314719

Proxazole or 3-alpha-Phenyl-propyl-5-beta-diethylaminoethyl-1,2,3-oxadiazole is a drug used for functional gastrointestinal disorders. It’s an unusual drug because it possesses both anti-inflammatory and antispasmodic properties and because each of these two properties has some uncommon features. The antiinflammatory action takes place mostly against edematous responses and is devoid of ulcerogenic effects which are instead produced by most anti-inflammatory drugs; moreover proxazole prevents indomethacin-induced ulcers without exerting any anti-secretory effect. The antispasmodic activity results in a specific inhibition of smooth muscle spasm, both at the vascular and at the intestinal level, without significant interferences with the physiologic activity of that tissue.

Originator

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Proxazole in cerebrovascular insufficiency. A controlled clinical trial.
1974 Oct
The effects of proxazole on renal function in chronic renal failure.
1981
Patents

Sample Use Guides

oral: 400 mg proxazole (5.2--6.5 mg/kg/day)
Route of Administration: Other
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:13:18 GMT 2023
Edited
by admin
on Fri Dec 15 16:13:18 GMT 2023
Record UNII
FD72T13M0K
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PROXAZOLE
INN   MI   USAN   WHO-DD  
USAN   INN  
Official Name English
PROPOXALINE
Common Name English
(±)-PROXAZOLE
Common Name English
PROXAZOLE [MI]
Common Name English
1,2,4-OXADIAZOLE, 5-(2-(DIETHYLAMINO)ETHYL)-3-(.ALPHA.-ETHYLBENZYL)-
Systematic Name English
proxazole [INN]
Common Name English
PROXAZOLE [USAN]
Common Name English
Proxazole [WHO-DD]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29698
Created by admin on Fri Dec 15 16:13:18 GMT 2023 , Edited by admin on Fri Dec 15 16:13:18 GMT 2023
WHO-VATC QA03AX07
Created by admin on Fri Dec 15 16:13:18 GMT 2023 , Edited by admin on Fri Dec 15 16:13:18 GMT 2023
WHO-ATC A03AX07
Created by admin on Fri Dec 15 16:13:18 GMT 2023 , Edited by admin on Fri Dec 15 16:13:18 GMT 2023
Code System Code Type Description
MERCK INDEX
m9282
Created by admin on Fri Dec 15 16:13:18 GMT 2023 , Edited by admin on Fri Dec 15 16:13:18 GMT 2023
PRIMARY Merck Index
DRUG CENTRAL
2321
Created by admin on Fri Dec 15 16:13:18 GMT 2023 , Edited by admin on Fri Dec 15 16:13:18 GMT 2023
PRIMARY
SMS_ID
100000080838
Created by admin on Fri Dec 15 16:13:18 GMT 2023 , Edited by admin on Fri Dec 15 16:13:18 GMT 2023
PRIMARY
EVMPD
SUB10146MIG
Created by admin on Fri Dec 15 16:13:18 GMT 2023 , Edited by admin on Fri Dec 15 16:13:18 GMT 2023
PRIMARY
ChEMBL
CHEMBL2106997
Created by admin on Fri Dec 15 16:13:18 GMT 2023 , Edited by admin on Fri Dec 15 16:13:18 GMT 2023
PRIMARY
EPA CompTox
DTXSID90859261
Created by admin on Fri Dec 15 16:13:18 GMT 2023 , Edited by admin on Fri Dec 15 16:13:18 GMT 2023
PRIMARY
WIKIPEDIA
PROXAZOLE
Created by admin on Fri Dec 15 16:13:18 GMT 2023 , Edited by admin on Fri Dec 15 16:13:18 GMT 2023
PRIMARY
PUBCHEM
8590
Created by admin on Fri Dec 15 16:13:18 GMT 2023 , Edited by admin on Fri Dec 15 16:13:18 GMT 2023
PRIMARY
FDA UNII
FD72T13M0K
Created by admin on Fri Dec 15 16:13:18 GMT 2023 , Edited by admin on Fri Dec 15 16:13:18 GMT 2023
PRIMARY
NCI_THESAURUS
C74176
Created by admin on Fri Dec 15 16:13:18 GMT 2023 , Edited by admin on Fri Dec 15 16:13:18 GMT 2023
PRIMARY
DRUG BANK
DB13819
Created by admin on Fri Dec 15 16:13:18 GMT 2023 , Edited by admin on Fri Dec 15 16:13:18 GMT 2023
PRIMARY
INN
1797
Created by admin on Fri Dec 15 16:13:18 GMT 2023 , Edited by admin on Fri Dec 15 16:13:18 GMT 2023
PRIMARY
CAS
31363-08-3
Created by admin on Fri Dec 15 16:13:18 GMT 2023 , Edited by admin on Fri Dec 15 16:13:18 GMT 2023
SUPERSEDED
CAS
5696-09-3
Created by admin on Fri Dec 15 16:13:18 GMT 2023 , Edited by admin on Fri Dec 15 16:13:18 GMT 2023
PRIMARY
MESH
C005583
Created by admin on Fri Dec 15 16:13:18 GMT 2023 , Edited by admin on Fri Dec 15 16:13:18 GMT 2023
PRIMARY
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SALT/SOLVATE -> PARENT
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ACTIVE MOIETY