Bremzalerbart

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NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 09:49:52 GMT 2025` Edited by `admin` on `Wed Apr 02 09:49:52 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG4
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	F8SN45N8HN
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Immunoglobulin G4 [224-proline], anti-(Betula alleghaniensis allergen Bet v 1) (human monoclonal REGN5713 ?4-chain), disulfide with human monoclonal REGN5713 ?-chain, dimer

Preferred Name

English

Bremzalerbart

Official Name

English

bremzalerbart [INN]

Common Name

English

immunoglobulin G4-kappa, anti-[Bet v 1 (Betula alleghaniensis (yellow birch) pollen allergen 1)], Homo sapiens monoclonal antibody, gamma4 heavy chain Homo sapiens (1-443) [VH (Homo sapiens IGHV4-59*01 (88.5%) -(IGHD) -IGHJ6*01 (94.4%), CDR-IMGT [8.7.10]

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C190442

Created by admin on Wed Apr 02 09:49:52 GMT 2025 , Edited by admin on Wed Apr 02 09:49:52 GMT 2025

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FDA UNII

F8SN45N8HN

Created by admin on Wed Apr 02 09:49:52 GMT 2025 , Edited by admin on Wed Apr 02 09:49:52 GMT 2025

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INN

12257

Created by admin on Wed Apr 02 09:49:52 GMT 2025 , Edited by admin on Wed Apr 02 09:49:52 GMT 2025

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CAS

2456307-07-4

Created by admin on Wed Apr 02 09:49:52 GMT 2025 , Edited by admin on Wed Apr 02 09:49:52 GMT 2025

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SMS_ID

300000040672

Created by admin on Wed Apr 02 09:49:52 GMT 2025 , Edited by admin on Wed Apr 02 09:49:52 GMT 2025

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From	To
1_22	1_95
2_22	2_95
2_130	4_214
2_143	2_199
2_257	2_317
1_130	3_214
2_363	2_421
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194
1_143	1_199
1_222	2_222
1_225	2_225
1_257	1_317
1_363	1_421

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_293
N	2_293

Related Record Type Details


					F8SN45N8HN

ACTIVE MOIETY

Comments:

As determined using SPR technology, the REGN5713, REGN5714, and REGN5715 equilibrium dissociation constants (KD) for nBet v 1 were 187, 933, and 747pM, respectively (Module 2.6.2 Section 2.1.1). REGN5713, REGN5714, and REGN5715 also bound rCar b 1 with KD values of 2.16, 59.1, and 1.91nM, respectively.

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS		Amount:	PIDOLIC ACID	SZB83O1W42
AMINO ACID REMOVAL	[1_443] [2_443]	C-TERMINUS			LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER AVERAGE	CHEMICAL