Bremzalerbart

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 17:55:54 GMT 2023` Edited by `admin` on `Sat Dec 16 17:55:54 GMT 2023`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG4
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	F8SN45N8HN
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

Bremzalerbart

Official Name

English

bremzalerbart [INN]

Common Name

English

Immunoglobulin G4 [224-proline], anti-(Betula alleghaniensis allergen Bet v 1) (human monoclonal REGN5713 γ4-chain), disulfide with human monoclonal REGN5713 κ-chain, dimer

Common Name

English

immunoglobulin G4-kappa, anti-[Bet v 1 (Betula alleghaniensis (yellow birch) pollen allergen 1)], Homo sapiens monoclonal antibody, gamma4 heavy chain Homo sapiens (1-443) [VH (Homo sapiens IGHV4-59*01 (88.5%) -(IGHD) -IGHJ6*01 (94.4%), CDR-IMGT [8.7.10]

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C190442

Created by admin on Sat Dec 16 17:55:54 GMT 2023 , Edited by admin on Sat Dec 16 17:55:54 GMT 2023

PRIMARY

FDA UNII

F8SN45N8HN

Created by admin on Sat Dec 16 17:55:54 GMT 2023 , Edited by admin on Sat Dec 16 17:55:54 GMT 2023

PRIMARY

INN

12257

Created by admin on Sat Dec 16 17:55:54 GMT 2023 , Edited by admin on Sat Dec 16 17:55:54 GMT 2023

PRIMARY

CAS

2456307-07-4

Created by admin on Sat Dec 16 17:55:54 GMT 2023 , Edited by admin on Sat Dec 16 17:55:54 GMT 2023

PRIMARY

From	To
1_22	1_95
2_22	2_95
2_130	4_214
2_143	2_199
2_257	2_317
1_130	3_214
2_363	2_421
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194
1_143	1_199
1_222	2_222
1_225	2_225
1_257	1_317
1_363	1_421

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_293
N	2_293

Related Record Type Details


					F8SN45N8HN

Bremzalerbart

ACTIVE MOIETY

Comments:

As determined using SPR technology, the REGN5713, REGN5714, and REGN5715 equilibrium dissociation constants (KD) for nBet v 1 were 187, 933, and 747pM, respectively (Module 2.6.2 Section 2.1.1). REGN5713, REGN5714, and REGN5715 also bound rCar b 1 with KD values of 2.16, 59.1, and 1.91nM, respectively.

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER AVERAGE	CHEMICAL