TRIETHYLENEMELAMINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C9H12N6
Molecular Weight	204.2318
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

C1CN1C2=NC(=NC(=N2)N3CC3)N4CC4

InChI

InChIKey=IUCJMVBFZDHPDX-UHFFFAOYSA-N

InChI=1S/C9H12N6/c1-2-13(1)7-10-8(14-3-4-14)12-9(11-7)15-5-6-15/h1-6H2

HIDE SMILES / InChI

Molecular Formula	C9H12N6
Molecular Weight	204.2318
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description

TRIETHYLENEMELAMINE, an aziridine derivative, is an alkylating agent with antineoplastic properties. Formerly it was used in the palliative treatment of the lymphomas and leukemias. Now it is used as a research tool to produce chromosome aberrations and cancers.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
DNA 278	Inhibitor 8,297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Cancer 592	Primary		Approved 8,429	Tretamine

Doses

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Dose	Population	Adverse events
5 mg 1 times / day multiple, oral (starting)	unhealthy, 41 - 70 years n = 6	Disc. AE: Nausea, Vomiting...

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AEs

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AE	Significance	Dose	Population
Nausea	severe, 1 patient Disc. AE	5 mg 1 times / day multiple, oral (starting)	unhealthy, 41 - 70 years n = 6
Vomiting	severe, 1 patient Disc. AE	5 mg 1 times / day multiple, oral (starting)	unhealthy, 41 - 70 years n = 6

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Sourcing

Sourcing

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Vendor/Aggregator	ID	URL
3B Scientific (Wuhan) Corp	3B3-056980	http://www.3bsc.com/index/pro_info.php?id=95515
Alfa Chemistry	51-18-3	https://www.alfa-chemistry.com/cas_51-18-3.htm
Ambinter	Amb2230427	http://www.ambinter.com/reference/2230427
Aurora Fine Chemicals LLC	A17.949.874	http://online.aurorafinechemicals.com/info?ID=A17.949.874
ChemMol	51504702	http://www.chemmol.com/chemmol/51504702.html

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PubMed

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Title	Date	PubMed
Radiation- and chemical-induced structural chromosome aberrations in human spermatozoa.	2002 Jul 25	12106658
A new alkaloid isolated from Abies webbiana leaf.	2010 May	21808564

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Patents

Substance Class	Chemical
Record UNII	F7IY6HZG9D
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TRIETHYLENEMELAMINE

Common Name

English

2,4,6-TRIS(1-AZIRIDINYL)-S-TRIAZINE

Common Name

English

2,4,6-TRIS(1-AZIRIDINYL)-S-TRIAZINE [IARC]

Common Name

English

Tretamine [WHO-DD]

Common Name

English

TRIETHYLENE MELAMINE

Common Name

English

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Classification Tree

Code System

Code

Antineoplastic Alkylating Agent

NCI_THESAURUS

C292

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Code System

Code

Type

Description

NCI_THESAURUS

C29858

PRIMARY

DRUG BANK

DB14031

PRIMARY

WIKIPEDIA

TRIETHYLENEMELAMINE

PRIMARY

PUBCHEM

5799

PRIMARY

CHEBI

27919

PRIMARY

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Related Record

Type

Details


					F7IY6HZG9D

TRIETHYLENEMELAMINE

ACTIVE MOIETY

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