U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C16H13ClO4S
Molecular Weight 336.79
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of RECILISIB

SMILES

OC(=O)C1=CC=C(\C=C\S(=O)(=O)CC2=CC=C(Cl)C=C2)C=C1

InChI

InChIKey=KBEKQQJUNVQLDZ-MDZDMXLPSA-N
InChI=1S/C16H13ClO4S/c17-15-7-3-13(4-8-15)11-22(20,21)10-9-12-1-5-14(6-2-12)16(18)19/h1-10H,11H2,(H,18,19)/b10-9+

HIDE SMILES / InChI

Molecular Formula C16H13ClO4S
Molecular Weight 336.79
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Recilisib (also known as EX-RAD or ON-01210) is a radioprotectant, which means that this compound can protect cells from harmful effects of ionizing radiation. Unlike other radioprotectors, recilisib is not a free-radical scavenger or responsible for cell cycle arrest. Recilisib was suggested to have a different radiation protection mechanism involving DNA repair pathways. This compound has been studied as prophylactic (use prior to radiation exposure) and therapeutic (after exposure to radiation) drug. In studies with healthy volunteers, recilisib was rapidly absorbed and well-tolerated, with only mild adverse events. Phase I clinical trials have been completed.

Approval Year

Substance Class Chemical
Created
by admin
on Sat Dec 16 03:00:04 UTC 2023
Edited
by admin
on Sat Dec 16 03:00:04 UTC 2023
Record UNII
F5V4K11SYV
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
RECILISIB
INN   USAN   WHO-DD  
USAN   INN  
Official Name English
recilisib [INN]
Common Name English
BENZOIC ACID, 4-((1E)-2-(((4-CHLOROPHENYL)METHYL)SULFONYL)ETHENYL)-
Common Name English
4-[(1E)-2-[[(4-Chlorophenyl)methyl]sulfonyl]ethenyl]benzoic acid
Systematic Name English
RECILISIB [USAN]
Common Name English
ON01210
Code English
ON-01210
Code English
Recilisib [WHO-DD]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C797
Created by admin on Sat Dec 16 03:00:04 UTC 2023 , Edited by admin on Sat Dec 16 03:00:04 UTC 2023
Code System Code Type Description
ChEMBL
CHEMBL2219421
Created by admin on Sat Dec 16 03:00:04 UTC 2023 , Edited by admin on Sat Dec 16 03:00:04 UTC 2023
PRIMARY
CAS
334969-03-8
Created by admin on Sat Dec 16 03:00:04 UTC 2023 , Edited by admin on Sat Dec 16 03:00:04 UTC 2023
PRIMARY
NCI_THESAURUS
C152168
Created by admin on Sat Dec 16 03:00:04 UTC 2023 , Edited by admin on Sat Dec 16 03:00:04 UTC 2023
PRIMARY
FDA UNII
F5V4K11SYV
Created by admin on Sat Dec 16 03:00:04 UTC 2023 , Edited by admin on Sat Dec 16 03:00:04 UTC 2023
PRIMARY
INN
9681
Created by admin on Sat Dec 16 03:00:04 UTC 2023 , Edited by admin on Sat Dec 16 03:00:04 UTC 2023
PRIMARY
USAN
ZZ-32
Created by admin on Sat Dec 16 03:00:04 UTC 2023 , Edited by admin on Sat Dec 16 03:00:04 UTC 2023
PRIMARY
EPA CompTox
DTXSID70187130
Created by admin on Sat Dec 16 03:00:04 UTC 2023 , Edited by admin on Sat Dec 16 03:00:04 UTC 2023
PRIMARY
PUBCHEM
9884220
Created by admin on Sat Dec 16 03:00:04 UTC 2023 , Edited by admin on Sat Dec 16 03:00:04 UTC 2023
PRIMARY
SMS_ID
300000034399
Created by admin on Sat Dec 16 03:00:04 UTC 2023 , Edited by admin on Sat Dec 16 03:00:04 UTC 2023
PRIMARY
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SALT/SOLVATE -> PARENT
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ACTIVE MOIETY