Details
Stereochemistry | ACHIRAL |
Molecular Formula | C16H13ClO4S |
Molecular Weight | 336.79 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 1 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)C1=CC=C(\C=C\S(=O)(=O)CC2=CC=C(Cl)C=C2)C=C1
InChI
InChIKey=KBEKQQJUNVQLDZ-MDZDMXLPSA-N
InChI=1S/C16H13ClO4S/c17-15-7-3-13(4-8-15)11-22(20,21)10-9-12-1-5-14(6-2-12)16(18)19/h1-10H,11H2,(H,18,19)/b10-9+
Molecular Formula | C16H13ClO4S |
Molecular Weight | 336.79 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 1 |
Optical Activity | NONE |
Recilisib (also known as EX-RAD or ON-01210) is a radioprotectant, which means that this compound can protect cells from harmful effects of ionizing radiation. Unlike other radioprotectors, recilisib is not a free-radical scavenger or responsible for cell cycle arrest. Recilisib was suggested to have a different radiation protection mechanism involving DNA repair pathways. This compound has been studied as prophylactic (use prior to radiation exposure) and therapeutic (after exposure to radiation) drug. In studies with healthy volunteers, recilisib was rapidly absorbed and well-tolerated, with only mild adverse events. Phase I clinical trials have been completed.
Originator
Approval Year
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 03:00:04 GMT 2023
by
admin
on
Sat Dec 16 03:00:04 GMT 2023
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Record UNII |
F5V4K11SYV
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Record Status |
Validated (UNII)
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Record Version |
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-
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Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C797
Created by
admin on Sat Dec 16 03:00:04 GMT 2023 , Edited by admin on Sat Dec 16 03:00:04 GMT 2023
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CHEMBL2219421
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334969-03-8
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C152168
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F5V4K11SYV
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9681
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ZZ-32
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DTXSID70187130
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9884220
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300000034399
Created by
admin on Sat Dec 16 03:00:04 GMT 2023 , Edited by admin on Sat Dec 16 03:00:04 GMT 2023
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Related Record | Type | Details | ||
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SALT/SOLVATE -> PARENT |
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ACTIVE MOIETY |
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