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Details

Stereochemistry ACHIRAL
Molecular Formula C16H12ClO4S.Na
Molecular Weight 358.772
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of RECILISIB SODIUM

SMILES

[Na+].[O-]C(=O)C1=CC=C(\C=C\S(=O)(=O)CC2=CC=C(Cl)C=C2)C=C1

InChI

InChIKey=PRFBWBYKWZVQJF-RRABGKBLSA-M
InChI=1S/C16H13ClO4S.Na/c17-15-7-3-13(4-8-15)11-22(20,21)10-9-12-1-5-14(6-2-12)16(18)19;/h1-10H,11H2,(H,18,19);/q;+1/p-1/b10-9+;

HIDE SMILES / InChI

Molecular Formula C16H12ClO4S
Molecular Weight 335.782
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Molecular Formula Na
Molecular Weight 22.9898
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Recilisib (also known as EX-RAD or ON-01210) is a radioprotectant, which means that this compound can protect cells from harmful effects of ionizing radiation. Unlike other radioprotectors, recilisib is not a free-radical scavenger or responsible for cell cycle arrest. Recilisib was suggested to have a different radiation protection mechanism involving DNA repair pathways. This compound has been studied as prophylactic (use prior to radiation exposure) and therapeutic (after exposure to radiation) drug. In studies with healthy volunteers, recilisib was rapidly absorbed and well-tolerated, with only mild adverse events. Phase I clinical trials have been completed.

Approval Year

Substance Class Chemical
Created
by admin
on Sat Dec 16 03:00:05 GMT 2023
Edited
by admin
on Sat Dec 16 03:00:05 GMT 2023
Record UNII
1068SXU525
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
RECILISIB SODIUM
USAN   WHO-DD  
USAN  
Official Name English
RECILISIB SODIUM [USAN]
Common Name English
SODIUM 4-((1E)-2-(((4-CHLOROPHENYL)METHYL)SULFONYL(ETHENYL)BENZOATE
Common Name English
ON 01210. NA
Code English
BENZOIC ACID, 4-((1E)-2-(((4-CHLOROPHENYL)METHYL)SULFONYL)ETHENYL)-, SODIUM SALT (1:1)
Common Name English
ON-01210.NA
Code English
Recilisib sodium [WHO-DD]
Common Name English
ON-01210 SODIUM
Code English
Classification Tree Code System Code
FDA ORPHAN DRUG 350311
Created by admin on Sat Dec 16 03:00:05 GMT 2023 , Edited by admin on Sat Dec 16 03:00:05 GMT 2023
FDA ORPHAN DRUG 350411
Created by admin on Sat Dec 16 03:00:05 GMT 2023 , Edited by admin on Sat Dec 16 03:00:05 GMT 2023
NCI_THESAURUS C797
Created by admin on Sat Dec 16 03:00:05 GMT 2023 , Edited by admin on Sat Dec 16 03:00:05 GMT 2023
Code System Code Type Description
CAS
922139-31-9
Created by admin on Sat Dec 16 03:00:05 GMT 2023 , Edited by admin on Sat Dec 16 03:00:05 GMT 2023
PRIMARY
NCI_THESAURUS
C152169
Created by admin on Sat Dec 16 03:00:05 GMT 2023 , Edited by admin on Sat Dec 16 03:00:05 GMT 2023
PRIMARY
EPA CompTox
DTXSID101336108
Created by admin on Sat Dec 16 03:00:05 GMT 2023 , Edited by admin on Sat Dec 16 03:00:05 GMT 2023
PRIMARY
ChEMBL
CHEMBL2219421
Created by admin on Sat Dec 16 03:00:05 GMT 2023 , Edited by admin on Sat Dec 16 03:00:05 GMT 2023
PRIMARY
SMS_ID
300000044538
Created by admin on Sat Dec 16 03:00:05 GMT 2023 , Edited by admin on Sat Dec 16 03:00:05 GMT 2023
PRIMARY
PUBCHEM
23668369
Created by admin on Sat Dec 16 03:00:05 GMT 2023 , Edited by admin on Sat Dec 16 03:00:05 GMT 2023
PRIMARY
USAN
ZZ-33
Created by admin on Sat Dec 16 03:00:05 GMT 2023 , Edited by admin on Sat Dec 16 03:00:05 GMT 2023
PRIMARY
FDA UNII
1068SXU525
Created by admin on Sat Dec 16 03:00:05 GMT 2023 , Edited by admin on Sat Dec 16 03:00:05 GMT 2023
PRIMARY
WIKIPEDIA
Ex-Rad
Created by admin on Sat Dec 16 03:00:05 GMT 2023 , Edited by admin on Sat Dec 16 03:00:05 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY