Tegoprubart

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 14:45:17 GMT 2023` Edited by `admin` on `Sat Dec 16 14:45:17 GMT 2023`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	EK87C62XNH
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Tegoprubart

Common Name

English

HUMANIZED ANTI-CD40LG IGG1, KAPPA MONOCLONAL ANTIBODY WITH HEAVY CHAIN C220S/C226S/C229S/P238S SUBSTITUTIONS TO ATTENUATE EFFECTOR FUNCTION

Common Name

English

AT-1501

Code

English

Immunoglobulin G1 [221-serine,227-serine,230-serine,239-serine], anti-(human CD40 ligand) (human-Mus musculus monoclonal AT-1501 γ1-chain), complex with human-Mus musculus monoclonal AT-1501 κ-chain, dimer

Common Name

English

tegoprubart [INN]

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

633818

Created by admin on Sat Dec 16 14:45:17 GMT 2023 , Edited by admin on Sat Dec 16 14:45:17 GMT 2023

FDA ORPHAN DRUG

881622

Created by admin on Sat Dec 16 14:45:17 GMT 2023 , Edited by admin on Sat Dec 16 14:45:17 GMT 2023

Code System Code Type Description

CAS

2628092-47-5

Created by admin on Sat Dec 16 14:45:17 GMT 2023 , Edited by admin on Sat Dec 16 14:45:17 GMT 2023

PRIMARY

INN

12545

Created by admin on Sat Dec 16 14:45:17 GMT 2023 , Edited by admin on Sat Dec 16 14:45:17 GMT 2023

PRIMARY

NCI_THESAURUS

C199118

Created by admin on Sat Dec 16 14:45:17 GMT 2023 , Edited by admin on Sat Dec 16 14:45:17 GMT 2023

PRIMARY

FDA UNII

EK87C62XNH

Created by admin on Sat Dec 16 14:45:17 GMT 2023 , Edited by admin on Sat Dec 16 14:45:17 GMT 2023

PRIMARY

From	To
1_22	1_96
1_145	1_201
1_262	1_322
1_368	1_426
2_22	2_96
2_145	2_201
2_262	2_322
2_368	2_426
3_23	3_92
3_138	3_198
4_23	4_92
4_138	4_198

Glycosylation Link Type	Site
N	1_298
N	2_298

Related Record Type Details


					61K7S69229

HUMAN CD40 LIGAND

TARGET -> INHIBITOR

Amount:


					YUF12AXR3B

CD40 LIGAND SOLUBLE

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					EK87C62XNH

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL