Divarasib

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C29H32ClF4N7O2
Molecular Weight	622.057
Optical Activity	UNSPECIFIED
Additional Stereochemistry	Yes
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0
Stereo Comments	AXIAL, R

SHOW SMILES / InChI

Structure Search

SMILES

C[C@H]1CN(CCN1C2=NC(OC[C@@H]3CCCN3C)=NC4=C(F)C(=C(Cl)C=C24)C5=C(C(C)=CC(N)=N5)C(F)(F)F)C(=O)C=C

InChI

InChIKey=ZRBPIAWWRPFDPY-IRXDYDNUSA-N

InChI=1S/C29H32ClF4N7O2/c1-5-21(42)40-9-10-41(16(3)13-40)27-18-12-19(30)22(26-23(29(32,33)34)15(2)11-20(35)36-26)24(31)25(18)37-28(38-27)43-14-17-7-6-8-39(17)4/h5,11-12,16-17H,1,6-10,13-14H2,2-4H3,(H2,35,36)/t16-,17-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C29H32ClF4N7O2
Molecular Weight	622.057
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Sat Dec 16 15:22:57 UTC 2023` Edited by `admin` on `Sat Dec 16 15:22:57 UTC 2023`
Record UNII	E6S21PVT91
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Divarasib

Official Name

English

DIVARASIB [USAN]

Common Name

English

RG-6330

Code

English

RO-7435846

Code

English

2-Propen-1-one, 1-[(3S)-4-[(7R)-7-[6-amino-4-methyl-3-(trifluoromethyl)-2-pyridinyl]-6-chloro-8-fluoro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]-4-quinazolinyl]-3-methyl-1-piperazinyl]-

Systematic Name

English

RO7435846

Code

English

RG6330

Code

English

divarasib [INN]

Common Name

English

GDC-6036

Code

English

1-{(3S)-4-[(7M)-7-[6-amino-4-methyl-3-(trifluoromethyl)pyridin-2-yl]-6-chloro-8-fluoro-2-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}quinazolin-4-yl]-3-methylpiperazin-1-yl}prop-2-en-1-one

Systematic Name

English

1-[(3S)-4-[(7R)-7-[6-Amino-4-methyl-3-(trifluoromethyl)-2-pyridinyl]-6-chloro-8-fluoro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]-4-quinazolinyl]-3-methyl-1-piperazinyl]-2-propen-1-one

Code

English

Code System Code Type Description

NCI_THESAURUS

C173995