Binds to the switch II pocket of the KRAS G12C covalently reactive with cysteine 12 and locks KRAS G12C protein in its GDP-bound inactive form. LY3499446 demonstrates timedependent KRAS G12C protein target occupancy with IC50 of 24.2 nM at 5 minutes and a measured kinact/KI of 47,586 M-1sec-1.
