MANNOMUSTINE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C10H22Cl2N2O4
Molecular Weight	305.199
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O[C@H](CNCCCl)[C@@H](O)[C@H](O)[C@H](O)CNCCCl

InChI

InChIKey=MQXVYODZCMMZEM-ZYUZMQFOSA-N

InChI=1S/C10H22Cl2N2O4/c11-1-3-13-5-7(15)9(17)10(18)8(16)6-14-4-2-12/h7-10,13-18H,1-6H2/t7-,8-,9-,10-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C10H22Cl2N2O4
Molecular Weight	305.199
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/13671231 | https://www.ncbi.nlm.nih.gov/pubmed/13910448 | https://link.springer.com/book/10.1007/978-1-4757-2085-3#about | https://www.drugfuture.com/chemdata/mannomustine.html

Mannomustine is a substance synthesized as one of a series of compounds linking the actively cytotoxic chemical group beta-chlorethylamine with a naturally occurring substance, mannitol. Mannomustine is an alkylating agent with antineoplastic properties. It was being studied in the treatment of hematologic malignancies.

Originator

Approval Year

PubMed

Title	Date	PubMed
Mannomustine in treatment of leukaemias, polycythaemia, and malignant disorders.	1959 Aug 22	13671231
Clinical results after 5 years of treatment of tumours and leukaemias with degranol (Mannomustine).	1961 Oct	13910448
Mannomustine (dihydrochloride).	1975	791830

Sample Use Guides

In Vivo Use Guide

the maximal single dose is 100 mg daily or on alternate days

Route of Administration: Other

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:56:04 GMT 2023` Edited by `admin` on `Sat Dec 16 17:56:04 GMT 2023`
Record UNII	E60VWA40D2
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MANNOMUSTINE

Official Name

English

1,6-BIS((2-CHLOROETHYL)AMINO)-1,6-DIDEOXY-D-MANNITOL

Systematic Name

English

NSC-9698 FREE BASE

Code

English

BCM

Code

English

mannomustine [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C697