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Details

Stereochemistry RACEMIC
Molecular Formula C16H33NO2
Molecular Weight 271.4393
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DELMOPINOL

SMILES

CCCC(CCC)CCCC1COCCN1CCO

InChI

InChIKey=QSFOWAYMMZCQNF-UHFFFAOYSA-N
InChI=1S/C16H33NO2/c1-3-6-15(7-4-2)8-5-9-16-14-19-13-11-17(16)10-12-18/h15-16,18H,3-14H2,1-2H3

HIDE SMILES / InChI

Molecular Formula C16H33NO2
Molecular Weight 271.4393
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Delmopinol, a surface-active cationic agent. It was approved by FDA under the name Decapinol for the treatment of gingivitis and prevention of periodontitis. The drug interacts with the early acquired pellicle, the thin layer of saliva polymers and proteins covering teeth and gums, and forms a barrier over teeth and gums. This barrier prevents the microbial adhesion and colonisation on the tooth and gum surface. Delmopinol itself has no bactericidal activity.

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Curative
DECAPINOL

Approved Use

DECAPINOL is a novel, first in class, medical device to help treat gingivitis and prevent periodontitis by preventing the plaque formation on the teeth’s and gum’s surface.

Launch Date

1078358400000
Preventing
DECAPINOL

Approved Use

DECAPINOL is a novel, first in class, medical device to help treat gingivitis and prevent periodontitis by preventing the plaque formation on the teeth’s and gum’s surface.

Launch Date

1078358400000
PubMed

PubMed

TitleDatePubMed
An in vitro study on effect of Delmopinol application on Candida albicans adherence on heat cured denture base acrylic resin: a thorough study.
2013 Sep-Oct
Patents

Sample Use Guides

Mouthwash formulation: Rinse 10ml of delmopinol (Decapinol mouthwash) for 30 sec and expectorate, use twice a day, avoid eating and drinking for about 30 minutes after the use of the mouthwash. Toothpaste formulation: Brush your teeth with delmopinol (decapinol toothpaste) as instructed by your dental professional.
Route of Administration: Dental
Bacteria isolated from samples of human dental plaque were treated with delmopinol mouthwash. Different dilutions of the delmopinol (100%, 50%, 25%, 12.5%, 6.25%, 3.12%, 1.56%, 0.78%, 0.39%, 0.19%) were tested to determine the MIC of bacterial growth. MIC values were 0.78% for Streptococcus mutants, 1.56% for Lactobacillus and 6.25 and 3.12 for aerobic and anaerobic bacterias, respectively.
Substance Class Chemical
Created
by admin
on Sat Jun 26 04:43:26 UTC 2021
Edited
by admin
on Sat Jun 26 04:43:26 UTC 2021
Record UNII
DT67WL708F
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DELMOPINOL
INN   MI   WHO-DD  
INN  
Official Name English
DELMOPINOL [WHO-DD]
Common Name English
DELMOPINOL [MI]
Common Name English
DELMOPINOL [INN]
Common Name English
(+/-)-3-(4-PROPYLHEPTYL)-4-MORPHOLINEETHANOL
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C83486
Created by admin on Sat Jun 26 04:43:26 UTC 2021 , Edited by admin on Sat Jun 26 04:43:26 UTC 2021
Code System Code Type Description
ChEMBL
CHEMBL2104220
Created by admin on Sat Jun 26 04:43:26 UTC 2021 , Edited by admin on Sat Jun 26 04:43:26 UTC 2021
PRIMARY
INN
5586
Created by admin on Sat Jun 26 04:43:26 UTC 2021 , Edited by admin on Sat Jun 26 04:43:26 UTC 2021
PRIMARY
MERCK INDEX
M4154
Created by admin on Sat Jun 26 04:43:26 UTC 2021 , Edited by admin on Sat Jun 26 04:43:26 UTC 2021
PRIMARY Merck Index
MESH
C073738
Created by admin on Sat Jun 26 04:43:26 UTC 2021 , Edited by admin on Sat Jun 26 04:43:26 UTC 2021
PRIMARY
NCI_THESAURUS
C78112
Created by admin on Sat Jun 26 04:43:26 UTC 2021 , Edited by admin on Sat Jun 26 04:43:26 UTC 2021
PRIMARY
CAS
79874-76-3
Created by admin on Sat Jun 26 04:43:26 UTC 2021 , Edited by admin on Sat Jun 26 04:43:26 UTC 2021
PRIMARY
DRUG CENTRAL
3131
Created by admin on Sat Jun 26 04:43:26 UTC 2021 , Edited by admin on Sat Jun 26 04:43:26 UTC 2021
PRIMARY
RXCUI
60451
Created by admin on Sat Jun 26 04:43:26 UTC 2021 , Edited by admin on Sat Jun 26 04:43:26 UTC 2021
PRIMARY RxNorm
PUBCHEM
57337
Created by admin on Sat Jun 26 04:43:26 UTC 2021 , Edited by admin on Sat Jun 26 04:43:26 UTC 2021
PRIMARY
FDA UNII
DT67WL708F
Created by admin on Sat Jun 26 04:43:26 UTC 2021 , Edited by admin on Sat Jun 26 04:43:26 UTC 2021
PRIMARY
EVMPD
SUB06956MIG
Created by admin on Sat Jun 26 04:43:26 UTC 2021 , Edited by admin on Sat Jun 26 04:43:26 UTC 2021
PRIMARY
Related Record Type Details
ENANTIOMER -> RACEMATE
ENANTIOMER -> RACEMATE
SALT/SOLVATE -> PARENT
Related Record Type Details
ACTIVE MOIETY