DELMOPINOL HYDROCHLORIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C16H33NO2.ClH
Molecular Weight	307.9
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CCCC(CCC)CCCC1COCCN1CCO

InChI

InChIKey=JFZBMJJFVBMZNC-UHFFFAOYSA-N

InChI=1S/C16H33NO2.ClH/c1-3-6-15(7-4-2)8-5-9-16-14-19-13-11-17(16)10-12-18;/h15-16,18H,3-14H2,1-2H3;1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C16H33NO2
Molecular Weight	271.4387
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.fda.gov/downloads/combinationproducts/jurisdictionalinformation/rfdjurisdictionaldecisions/redacteddecisionletters/ucm113777.pdf

Delmopinol, a surface-active cationic agent. It was approved by FDA under the name Decapinol for the treatment of gingivitis and prevention of periodontitis. The drug interacts with the early acquired pellicle, the thin layer of saliva polymers and proteins covering teeth and gums, and forms a barrier over teeth and gums. This barrier prevents the microbial adhesion and colonisation on the tooth and gum surface. Delmopinol itself has no bactericidal activity.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Dental pellicle 2 Target ID: Dental pellicle Sources: https://www.fda.gov/downloads/combinationproducts/jurisdictionalinformation/rfdjurisdictionaldecisions/redacteddecisionletters/ucm113777.pdf	Interacts 323

Conditions

Condition	Modality	Targets	Highest Phase	Product
Gingivitis 45 Sources: https://www.aegisdentalnetwork.com/ida/2011/10/g-u-m-perioshield-oral-health-rinse http://gumdiseaseinfo.org.uk/decapinol/--OFF--/ http://us-professional.gumbrand.com/gumr-perioshieldtm-oral-health-rinse.html	Curative		Approved 8583	DECAPINOL Approved Use DECAPINOL is a novel, first in class, medical device to help treat gingivitis and prevent periodontitis by preventing the plaque formation on the teeth’s and gum’s surface. Launch Date 2004
Periodontitis 23 Sources: https://www.aegisdentalnetwork.com/ida/2011/10/g-u-m-perioshield-oral-health-rinse http://gumdiseaseinfo.org.uk/decapinol/--OFF--/ http://us-professional.gumbrand.com/gumr-perioshieldtm-oral-health-rinse.html	Preventing		Approved 8583	DECAPINOL Approved Use DECAPINOL is a novel, first in class, medical device to help treat gingivitis and prevent periodontitis by preventing the plaque formation on the teeth’s and gum’s surface. Launch Date 2004

C_max

Value	Dose	Co-administered	Analyte	Population
49 nM EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/9879639/	10 mL single, oral transmucosal dose: 10 mL route of administration: Oral transmucosal experiment type: SINGLE co-administered:		DELMOPINOL plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
8 nM EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/9879639/	10 mL single, oral dose: 10 mL route of administration: Oral experiment type: SINGLE co-administered:		DELMOPINOL plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED

AUC

Value	Dose	Co-administered	Analyte	Population
160 nM × h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/9879639/	10 mL single, oral transmucosal dose: 10 mL route of administration: Oral transmucosal experiment type: SINGLE co-administered:		DELMOPINOL plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED
15 nM × h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/9879639/	10 mL single, oral dose: 10 mL route of administration: Oral experiment type: SINGLE co-administered:		DELMOPINOL plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED

T_1/2

Value	Dose	Co-administered	Analyte	Population
2.4 h EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/9879639/	10 mL single, oral transmucosal dose: 10 mL route of administration: Oral transmucosal experiment type: SINGLE co-administered:		DELMOPINOL plasma	Homo sapiens population: HEALTHY age: ADULT sex: MALE food status: FASTED

PubMed

Title	Date	PubMed
In vitro study of the effect of an essential oil and a delmopinol mouth rinse on dental plaque bacteria.	2017-02-08	28169264
An in vitro study on effect of Delmopinol application on Candida albicans adherence on heat cured denture base acrylic resin: a thorough study.	2013-12-21	24355973
6-month use of 0.2% delmopinol hydrochloride in comparison with 0.2% chlorhexidine digluconate and placebo. (I). Effect on plaque formation and gingivitis.	1998-09	9763330

Patents

Sample Use Guides

In Vivo Use Guide

Mouthwash formulation: Rinse 10ml of delmopinol (Decapinol mouthwash) for 30 sec and expectorate, use twice a day, avoid eating and drinking for about 30 minutes after the use of the mouthwash. Toothpaste formulation: Brush your teeth with delmopinol (decapinol toothpaste) as instructed by your dental professional.

Route of Administration: Dental

In Vitro Use Guide

Bacteria isolated from samples of human dental plaque were treated with delmopinol mouthwash. Different dilutions of the delmopinol (100%, 50%, 25%, 12.5%, 6.25%, 3.12%, 1.56%, 0.78%, 0.39%, 0.19%) were tested to determine the MIC of bacterial growth. MIC values were 0.78% for Streptococcus mutants, 1.56% for Lactobacillus and 6.25 and 3.12 for aerobic and anaerobic bacterias, respectively.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:03:58 GMT 2025` Edited by `admin` on `Mon Mar 31 18:03:58 GMT 2025`
Record UNII	SRE423V9Z9
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DELMOPINOL HCL

Preferred Name

English

DELMOPINOL HYDROCHLORIDE

Common Name

English

DECAPINOL

Brand Name

English

4-MORPHOLINEETHANOL, 3-(4-PROPYLHEPTYL)-, HYDROCHLORIDE

Systematic Name

English

M-1650

Code

English

DELMOPINOL HYDROCHLORIDE [MI]

Common Name

English

4-MORPHOLINEETHANOL, 3-(4-PROPYLHEPTYL)-, HYDROCHLORIDE (1:1)

Systematic Name

English

Code System Code Type Description

FDA UNII

SRE423V9Z9