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Details

Stereochemistry ACHIRAL
Molecular Formula C19H22N4O2
Molecular Weight 338.4036
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PUMAPRAZOLE

SMILES

COC(=O)NC1=CC=CC(C)=C1CNC2=CC=CN3C(C)=C(C)N=C23

InChI

InChIKey=NZQTVUWEPPDOKK-UHFFFAOYSA-N
InChI=1S/C19H22N4O2/c1-12-7-5-8-16(22-19(24)25-4)15(12)11-20-17-9-6-10-23-14(3)13(2)21-18(17)23/h5-10,20H,11H2,1-4H3,(H,22,24)

HIDE SMILES / InChI

Molecular Formula C19H22N4O2
Molecular Weight 338.4036
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Pumaprazole is imidazopyridine derivative patented by Byk Gulden Lomberg Chemische Fabrik GmbH for the treatment of gastrointestinal diseases. Pumaprazole acts as a reversibly binding acid pump antagonist. Pumaprazole differs from covalently binding proton pump inhibitors (PPIs), such as omeprazole, both with respect to chemical structure and mode of interaction with the gastric H(+)/K(+)-ATPase. In preclinical models, the single dose of Pumaprazole is able to elevate intragastric pH in the dog with gastric fistula under pentagastrin or carbachol stimulation from pH 1 to about pH 7 while still displaying a dose-dependent, well-controllable duration of action of a few hours.

Approval Year

PubMed

PubMed

TitleDatePubMed
Animal pharmacology of reversible antagonism of the gastric acid pump, compared to standard antisecretory principles.
2000 May
Patents
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:42:05 GMT 2023
Edited
by admin
on Fri Dec 15 15:42:05 GMT 2023
Record UNII
DK95Z519WL
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PUMAPRAZOLE
INN  
INN  
Official Name English
BY-941
Code English
BY941
Code English
pumaprazole [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29723
Created by admin on Fri Dec 15 15:42:05 GMT 2023 , Edited by admin on Fri Dec 15 15:42:05 GMT 2023
Code System Code Type Description
CAS
158364-59-1
Created by admin on Fri Dec 15 15:42:05 GMT 2023 , Edited by admin on Fri Dec 15 15:42:05 GMT 2023
PRIMARY
ChEMBL
CHEMBL2105279
Created by admin on Fri Dec 15 15:42:05 GMT 2023 , Edited by admin on Fri Dec 15 15:42:05 GMT 2023
PRIMARY
INN
7461
Created by admin on Fri Dec 15 15:42:05 GMT 2023 , Edited by admin on Fri Dec 15 15:42:05 GMT 2023
PRIMARY
NCI_THESAURUS
C73221
Created by admin on Fri Dec 15 15:42:05 GMT 2023 , Edited by admin on Fri Dec 15 15:42:05 GMT 2023
PRIMARY
FDA UNII
DK95Z519WL
Created by admin on Fri Dec 15 15:42:05 GMT 2023 , Edited by admin on Fri Dec 15 15:42:05 GMT 2023
PRIMARY
SMS_ID
100000080844
Created by admin on Fri Dec 15 15:42:05 GMT 2023 , Edited by admin on Fri Dec 15 15:42:05 GMT 2023
PRIMARY
EPA CompTox
DTXSID90166407
Created by admin on Fri Dec 15 15:42:05 GMT 2023 , Edited by admin on Fri Dec 15 15:42:05 GMT 2023
PRIMARY
PUBCHEM
3052764
Created by admin on Fri Dec 15 15:42:05 GMT 2023 , Edited by admin on Fri Dec 15 15:42:05 GMT 2023
PRIMARY
EVMPD
SUB10159MIG
Created by admin on Fri Dec 15 15:42:05 GMT 2023 , Edited by admin on Fri Dec 15 15:42:05 GMT 2023
PRIMARY
Related Record Type Details
TARGET -> INHIBITOR
Binds to potassium site
REVERSIBLE
Related Record Type Details
ACTIVE MOIETY