BELANTAMAB MAFODOTIN

Approval Year

Substance Class	Protein
Protein Type	MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED MURINE
Sequence Type	COMPLETE
Record UNII	DB1041CXDG
Record Status	`Validated (UNII)`
Record Version

Related Record	Type
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Name

Type

Language

BELANTAMAB MAFODOTIN

Official Name

English

belantamab mafodotin [INN]

Preferred Name

English

GSK2857916

Code

English

BELANTAMAB MAFODOTIN [MI]

Common Name

English

BELANTAMAB MAFODOTIN [USAN]

Common Name

English

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Classification Tree

Code System

Code

Designated/Approved

FDA ORPHAN DRUG

590517

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Code System

Code

Type

Description

NCI_THESAURUS

C114299

PRIMARY

USAN

GH-35

PRIMARY

CAS

2050232-20-5

PRIMARY

WIKIPEDIA

Belantamab mafodotin

PRIMARY

INN

10754

PRIMARY

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Subunit 0

Subunit 1

Subunit 2

Subunit 3

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From	To
1_22	1_96
2_22	2_96
2_148	2_204
2_224	4_214
2_265	2_325

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Glycosylation Type

MAMMALIAN, AFUCOSYLATED

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Glycosylation Link Type	Site
N	1_301
N	2_301

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Related Record

Type

Details


					7M3UL8MR2Y

BELANTAMAB

CONJUGATE COMPONENT->CONJUGATE

Amount:


					O19V2N6W9T

MAFODOTIN

CONJUGATE COMPONENT->CONJUGATE

Amount:


					PK6VHJAIBD

TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 17

TARGET->CONJUGATED TOXIN

Amount:


					1Z1AI9IW5L

MONOMETHYL AURISTATIN F

TOXIN -> CONJUGATE

Amount:

BELANTAMAB MAFODOTIN-BLMF

SUB_CONCEPT->SUBSTANCE

Amount:

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Related Record

Type

Details


					DB1041CXDG

BELANTAMAB MAFODOTIN

ACTIVE MOIETY

Amount:

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Structural Modifications

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Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_224] [1_230] [1_233] [2_224] [2_230] [2_233] [3_214] [4_214]		CYSTEINE	Amount: MOL RATIO 4 (average)	CYSTEINYL-MAFODOTIN	B4S8ET206U
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS			PIDOLIC ACID	SZB83O1W42

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Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL	ESTIMATED C6484H10038O2026N1728S44
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL	ESTIMATED 146000 Da (average)

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