Efzilonkofusp Alfa

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 20:11:12 GMT 2025` Edited by `admin` on `Wed Apr 02 20:11:12 GMT 2025`
Protein Type	FUSION PROTEINS
Protein Sub Type	IGG4
Sequence Type	COMPLETE
Record UNII	D83KB6PH3Y
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

1-208-CD80 antigen (human) fusion protein with peptide linker (GS(GGGGS)3) fusion protein with immunoglobulin G4 (recombinant human ?4-chain hinge-CH2-CH3 fragment) fusion protein with peptide linker (GGGGS) fusion protein with interleukin 2 [38-alanine,

Preferred Name

English

Efzilonkofusp Alfa

Official Name

English

efzilonkofusp alfa [INN]

Common Name

English

human T-lymphocyte activation antigen CD80 (activation B7-1 antigen, CTLA-4 counter-receptor B7.1, CD80) extracellular domain containing fragment (1-208 in the current sequence) fused via peptide linker <sup>209</sup>GSGGGGSGGGGSGGGGS<sup>225</sup> to an

Common Name

English

Code System Code Type Description

INN

13123

Created by admin on Wed Apr 02 20:11:12 GMT 2025 , Edited by admin on Wed Apr 02 20:11:12 GMT 2025

PRIMARY

NCI_THESAURUS

C211710

Created by admin on Wed Apr 02 20:11:12 GMT 2025 , Edited by admin on Wed Apr 02 20:11:12 GMT 2025

PRIMARY

FDA UNII

D83KB6PH3Y

Created by admin on Wed Apr 02 20:11:12 GMT 2025 , Edited by admin on Wed Apr 02 20:11:12 GMT 2025

PRIMARY

CAS

2922216-50-8

Created by admin on Wed Apr 02 20:11:12 GMT 2025 , Edited by admin on Wed Apr 02 20:11:12 GMT 2025

PRIMARY

From	To
2_517	2_564
2_375	2_433
2_269	2_329
2_128	2_182
2_16	2_82
1_517	1_564
1_375	1_433
1_269	1_329
1_237	2_237
1_234	2_234
1_128	1_182
1_16	1_82

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_19
N	1_55
N	1_64
N	1_152
N	1_173
N	1_177
N	1_192
N	1_198
N	1_305
N	2_19
N	2_55
N	2_64
N	2_152
N	2_173
N	2_177
N	2_192
N	2_198
N	2_305
O	1_220
O	1_462
O	2_220
O	2_462

Related Record Type Details


					DN82J7Z829

Interleukin-2 receptor subunit beta and gamma complex

TARGET->LIGAND

Amount:


					KYU4T5WAI2

CYTOTOXIC T-LYMPHOCYTE PROTEIN 4

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					D83KB6PH3Y

Efzilonkofusp Alfa

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL