PELACARSEN SODIUM

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Sat Dec 16 13:42:35 GMT 2023` Edited by `admin` on `Sat Dec 16 13:42:35 GMT 2023`
Nucleic Acid Type	OLIGONUCLEOTIDE
Nucleic Acid Subtype
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	D1J27662O8
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PELACARSEN SODIUM

Official Name

English

ISIS-681257 (GALNAC3--CONJUGATED ASO TARGETING HUMAN LIPOPROTEIN (A) )

Common Name

English

ISIS-681257 SODIUM

Code

English

ISIS-681257

Code

English

DNA, D((2'-O-(2-METHOXYETHYL))M5RU-SP-(2'-O-(2-METHOXYETHYL))RG-(2'-O-(2-METHOXYETHYL))M5RC-(2'-O-(2-METHOXYETHYL))M5RU-(2'-O-(2-METHOXYETHYL))M5RC-M5C-SP-G-SP-T-SP-T-SP-G-SP-G-SP-T-SP-G-SP-M5C-SP-T-SP-(2'-O-(2-METHOXYETHYL))M5RU-(2'-O-(2-METHOXYETHYL))R

Systematic Name

English

PELACARSEN SODIUM [USAN]

Common Name

English

Code System Code Type Description

USAN

FG-173

Created by admin on Sat Dec 16 13:42:35 GMT 2023 , Edited by admin on Sat Dec 16 13:42:35 GMT 2023

PRIMARY

NCI_THESAURUS

C174665

Created by admin on Sat Dec 16 13:42:35 GMT 2023 , Edited by admin on Sat Dec 16 13:42:35 GMT 2023

PRIMARY

FDA UNII

D1J27662O8

Created by admin on Sat Dec 16 13:42:35 GMT 2023 , Edited by admin on Sat Dec 16 13:42:35 GMT 2023

PRIMARY

CAS

2172851-58-8

Created by admin on Sat Dec 16 13:42:35 GMT 2023 , Edited by admin on Sat Dec 16 13:42:35 GMT 2023

PRIMARY

Sugar	Site Range	Site Count
Deoxyribose (DNA)	1_7-1_15	9 / 20
2'-O-Methoxyethyl ribose	1_1-1_6;1_16-1_20	11 / 20

Linkage	Site Range	Site Count
	1_3-1_5;1_17-1_19	6 / 19
Sodium Phosporothioate	1_2;1_6-1_16;1_20	13 / 19

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PELACARSEN

PARENT -> SALT/SOLVATE

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					LSO9H7UZ90

PELACARSEN

ACTIVE MOIETY

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOSIDE BASE SUBSTITUTION	[1_3] [1_5] [1_6] [1_14] [1_20]	SITE_SPECIFIC			5-METHYLCYTOSINE	6R795CQT4H
NUCLEOSIDE_SUBSTITUTION	[1_1]	5'-TERMINUS			UNSPECIFIED SUBSTANCE	3a98b2f0 (not in database)