U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Nucleic Acid
Created
by admin
on Sat Dec 16 13:42:36 GMT 2023
Edited
by admin
on Sat Dec 16 13:42:36 GMT 2023
Nucleic Acid Type OLIGONUCLEOTIDE
Nucleic Acid Subtype
Sequence Type COMPLETE
Record UNII
LSO9H7UZ90
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PELACARSEN
USAN   INN  
Official Name English
ISIS-681257 (GALNAC3--CONJUGATED ASO TARGETING HUMAN LIPOPROTEIN (A)) FREE ACID
Common Name English
ALL-P-AMBO-5-O-(((6-(5-((TRIS(3-(6-(2-ACETAMIDO-2-DEOXY-.BETA.-D-GALACTOPYRANOSYLOXY)HEXYLAMINO)-3-OXOPROPOXYMETHYL))METHYL)AMINO-5-OXOPENTANAMIDO)HEXOXY))PHOSPHO)-2-O-(2-METHOXYETHYL)-5-METHYL-P-THIOURIDYLYL-(3-O->5-O)-2-O-(2-METHOXYETHYL)GUANYLYL-(3-O-
Common Name English
AKCEA-APO(A)-LRX
Common Name English
Pelacarsen [WHO-DD]
Common Name English
PELACARSEN [USAN]
Common Name English
IONIS-APO(A)-LRX
Common Name English
pelacarsen [INN]
Common Name English
DNA, D((2'-O-(2-METHOXYETHYL))M5RU-SP-(2'-O-(2-METHOXYETHYL))RG-(2'-O-(2-METHOXYETHYL))M5RC-(2'-O-(2-METHOXYETHYL))M5RU-(2'-O-(2-METHOXYETHYL))M5RC-M5C-SP-G-SP-T-SP-T-SP-G-SP-G-SP-T-SP-G-SP-M5C-SP-T-SP-(2'-O-(2-METHOXYETHYL))M5RU-(2'-O-(2-METHOXYETHYL))R
Systematic Name English
ISIS-681257 FREE ACID
Code English
Code System Code Type Description
FDA UNII
LSO9H7UZ90
Created by admin on Sat Dec 16 13:42:36 GMT 2023 , Edited by admin on Sat Dec 16 13:42:36 GMT 2023
PRIMARY
CAS
1637637-70-7
Created by admin on Sat Dec 16 13:42:36 GMT 2023 , Edited by admin on Sat Dec 16 13:42:36 GMT 2023
PRIMARY
NCI_THESAURUS
C174676
Created by admin on Sat Dec 16 13:42:36 GMT 2023 , Edited by admin on Sat Dec 16 13:42:36 GMT 2023
PRIMARY
INN
11187
Created by admin on Sat Dec 16 13:42:36 GMT 2023 , Edited by admin on Sat Dec 16 13:42:36 GMT 2023
PRIMARY
USAN
FG-172
Created by admin on Sat Dec 16 13:42:36 GMT 2023 , Edited by admin on Sat Dec 16 13:42:36 GMT 2023
PRIMARY
CAS
1637639-99-6
Created by admin on Sat Dec 16 13:42:36 GMT 2023 , Edited by admin on Sat Dec 16 13:42:36 GMT 2023
ALTERNATIVE
Sugar Site Range Site Count
Deoxyribose (DNA) 1_7-1_15 9 / 20
2'-O-Methoxyethyl ribose 1_1-1_6;1_16-1_20 11 / 20
Linkage Site Range Site Count
Phosporothioate 1_2;1_7-1_16;1_20 12 / 19
Phosphate 1_3-1_6;1_17-1_19 7 / 19
Related Record Type Details
SALT/SOLVATE -> PARENT
TARGET->INHIBITOR OF EXPRESSION
Related Record Type Details
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
NUCLEOSIDE BASE SUBSTITUTION [1_3] [1_5] [1_6] [1_14] [1_20] SITE_SPECIFIC 5-METHYLCYTOSINE 6R795CQT4H
NUCLEOSIDE_SUBSTITUTION [1_1] 5'-TERMINUS UNSPECIFIED SUBSTANCE
69c9da7b
(not in database)