| Stereochemistry | RACEMIC |
| Molecular Formula | C11H12N2S |
| Molecular Weight | 204.291 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C1CN2CC(N=C2S1)C3=CC=CC=C3
InChI
InChIKey=HLFSDGLLUJUHTE-UHFFFAOYSA-N
InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2
| Molecular Formula | C11H12N2S |
| Molecular Weight | 204.291 |
| Charge | 0 |
| Count |
MOL RATIO
1 MOL RATIO (average) |
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
Tetramisole is a racemic mixture of levamisole and its enantiomer dexamisole, which is a specific inhibitor of tissue non-specific alkaline phosphatase (TNAP). This drug is used in veterinary to treat of ascariasis and other worm infections e.g hook-"ms. And also is used as an immunostimulant (in that case it is used for longer periods of time).
Approval Year
PubMed
Sample Use Guides
veterinary:
Cattle , Sheep, Goats and Horses : 0.33 gm Tetramisole HCI
10 % per 20 kg b.wt. In a single oral dose given as a drench in water or mixed with fodder
Route of Administration:
Oral
Various enzymes of the tricarboxylic acid cycle (TCA) viz., aconitase (E.C. 4.2.1.3), isocitrate dehydrogenase (E.C. 1.1.1.42), succinate dehydrognease (E.C. 1.3.99.1), fumarate reductase (NADH: fumarate oxido-reductase), fumarase (E.C. 4.2.1.2) and maltate dehydrogenase (E.C. 1.1.1.37) were detected in adult Haemonchus contortus (Nematoda: Trichostrongylidae), in vitro. The effects of D L-tetramisole on various enzymes were studied. At 50 micrograms ml-1 varying degrees of inhibition of succinate dehydrogenase and fumarate reductase activities were observed. At the same concentration, the activities of other enzymes remained unaltered.
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SALT/SOLVATE -> PARENT |
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ENANTIOMER -> RACEMATE |
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ENANTIOMER -> RACEMATE |
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