TROPATEPINE

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National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	RACEMIC
Molecular Formula	C22H23NS
Molecular Weight	333.49
Optical Activity	( + / - )
Defined Stereocenters	2 / 2
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure of TROPATEPINE

Structure Search

SMILES

CN1[C@H]2CC[C@@H]1C\C(C2)=C3\C4=C(CSC5=C3C=CC=C5)C=CC=C4

InChI

InChIKey=JOQKFRLFXDPXHX-YFUWWQDYSA-N

InChI=1S/C22H23NS/c1-23-17-10-11-18(23)13-16(12-17)22-19-7-3-2-6-15(19)14-24-21-9-5-4-8-20(21)22/h2-9,17-18H,10-14H2,1H3/b22-16-/t17-,18+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C22H23NS
Molecular Weight	333.49
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	1
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2769291 | https://www.onmeda.fr/medicament/lepticur-93140500.html

Tropatepine is an anticholinergic drug. Intramuscular injections of tropatepine are used to counteract the extrapyramidal effects of neuroleptic drugs and for the treatment of Parkinson's disease. The drug is marketed in Europe under tradename Lepticur.

Approval Year

PubMed

PubMed

Title	Date	PubMed
Effect of tropatepine, an anticholinergic drug, on regional cerebral blood flow in patients with Parkinson's disease.	1989-07	2769291

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:47:43 GMT 2025` Edited by `admin` on `Mon Mar 31 18:47:43 GMT 2025`
Record UNII	C27HY5RFU5
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

SD-1248-17 FREE BASE

Preferred Name

English

TROPATEPINE

Official Name

English

(±)-3-DIBENZO(B,E)THIEPIN-11-(6H)-YLIDENE-1.ALPHA.H,5.ALPHA.H-TROPANE

Common Name

English

Tropatepine [WHO-DD]

Common Name

English

tropatepine [INN]

Common Name

English

3-DIBENZO(B,E)THIEPIN-11(6H)-YLIDENE-1.ALPHA.H,5.ALPHA.H-TROPANE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C38149

Created by admin on Mon Mar 31 18:47:43 GMT 2025 , Edited by admin on Mon Mar 31 18:47:43 GMT 2025

NCI_THESAURUS

C29698

Created by admin on Mon Mar 31 18:47:43 GMT 2025 , Edited by admin on Mon Mar 31 18:47:43 GMT 2025

WHO-VATC

QN04AA12

Created by admin on Mon Mar 31 18:47:43 GMT 2025 , Edited by admin on Mon Mar 31 18:47:43 GMT 2025

WHO-ATC

N04AA12

Created by admin on Mon Mar 31 18:47:43 GMT 2025 , Edited by admin on Mon Mar 31 18:47:43 GMT 2025

Code System Code Type Description

INN

3250

Created by admin on Mon Mar 31 18:47:43 GMT 2025 , Edited by admin on Mon Mar 31 18:47:43 GMT 2025

PRIMARY

CAS

27574-24-9

Created by admin on Mon Mar 31 18:47:43 GMT 2025 , Edited by admin on Mon Mar 31 18:47:43 GMT 2025

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DRUG BANK

DB13252

Created by admin on Mon Mar 31 18:47:43 GMT 2025 , Edited by admin on Mon Mar 31 18:47:43 GMT 2025

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SMS_ID

100000076959

Created by admin on Mon Mar 31 18:47:43 GMT 2025 , Edited by admin on Mon Mar 31 18:47:43 GMT 2025

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FDA UNII

C27HY5RFU5

Created by admin on Mon Mar 31 18:47:43 GMT 2025 , Edited by admin on Mon Mar 31 18:47:43 GMT 2025

PRIMARY

EPA CompTox

DTXSID70865380

Created by admin on Mon Mar 31 18:47:43 GMT 2025 , Edited by admin on Mon Mar 31 18:47:43 GMT 2025

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MESH

C013322

Created by admin on Mon Mar 31 18:47:43 GMT 2025 , Edited by admin on Mon Mar 31 18:47:43 GMT 2025

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ChEMBL

CHEMBL2107294

Created by admin on Mon Mar 31 18:47:43 GMT 2025 , Edited by admin on Mon Mar 31 18:47:43 GMT 2025

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WIKIPEDIA

Tropatepine

Created by admin on Mon Mar 31 18:47:43 GMT 2025 , Edited by admin on Mon Mar 31 18:47:43 GMT 2025

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DRUG CENTRAL

2772

Created by admin on Mon Mar 31 18:47:43 GMT 2025 , Edited by admin on Mon Mar 31 18:47:43 GMT 2025

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NCI_THESAURUS

C152762

Created by admin on Mon Mar 31 18:47:43 GMT 2025 , Edited by admin on Mon Mar 31 18:47:43 GMT 2025

PRIMARY

EVMPD

SUB11340MIG

Created by admin on Mon Mar 31 18:47:43 GMT 2025 , Edited by admin on Mon Mar 31 18:47:43 GMT 2025

PRIMARY

RXCUI

38876

Created by admin on Mon Mar 31 18:47:43 GMT 2025 , Edited by admin on Mon Mar 31 18:47:43 GMT 2025

PRIMARY

RxNorm

Related Record Type Details


					17N1U39U3Z

TROPATEPINE HYDROCHLORIDE

SALT/SOLVATE -> PARENT

Related Record Type Details


					C27HY5RFU5

ACTIVE MOIETY