SODIUM SULFIDE NONAHYDRATE

US Approved OTC

Details

Stereochemistry	ACHIRAL
Molecular Formula	2Na.S.9H2O
Molecular Weight	240.182
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O.O.O.O.O.O.O.O.O.[Na+].[Na+].[S--]

InChI

InChIKey=ZGHLCBJZQLNUAZ-UHFFFAOYSA-N

InChI=1S/2Na.9H2O.S/h;;9*1H2;/q2*+1;;;;;;;;;;-2

HIDE SMILES / InChI

Molecular Formula	H2O
Molecular Weight	18.0153
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Na
Molecular Weight	22.98976928
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	HS
Molecular Weight	33.073
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22044162https://www.ncbi.nlm.nih.gov/pubmed/22178752 | https://www.ncbi.nlm.nih.gov/pubmed/22178753https://www.ncbi.nlm.nih.gov/pubmed/11692231 | https://www.ncbi.nlm.nih.gov/pubmed/12382079https://sciencing.com/difference-between-sulfide-sulfite-8559544.html | https://chem.libretexts.org/Bookshelves/Analytical_Chemistry/Supplemental_Modules_(Analytical_Chemistry)/Qualitative_Analysis/Properties_of_Select_Nonmetal_Ions/Sulfide_Ion_(S%E2%82%82%E2%81%BB) | https://www.scbt.com/scbt/product/sodium-sulfide-nonahydrate-1313-84-4

A sulfide ion is composed of a lone sulfur atom. Its charge is negative two, giving sulfides this formula: S^2-. Sulfide is a strong base, so solutions of sulfide in water are basic, due to hydrolysis. One well-known ionic compound with a sulfide ion is H_2S. The infamous rotten-egg smell often associated with sulfur originates from this compound. Sodium sulfide nonahydrate is used in the formation of surface functionalized cadmium sulfide quantum dots.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Potency
Sodium bicarbonate cotransporter 3 5 Target ID: Q9Y6M7\|\|\|B6DY53 Gene ID: 9497.0 Gene Symbol: SLC4A7 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/18204485	Inhibitor 8504	1.7 µM [Ki]
Electrogenic sodium bicarbonate cotransporter 1 5 Target ID: Q9Y6R1\|\|\|Q9UP50 Gene ID: 8671.0 Gene Symbol: SLC4A4 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/26027796	Inhibitor 8504	9.0 µM [IC50]
Malignant T-cell-amplified sequence 1 5 Target ID: Q9ULC4 Gene ID: 28985.0 Gene Symbol: MCTS1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/26027796	Inhibitor 8504	10.0 µM [IC50]
Monocarboxylate transporter 2 6 Target ID: O60669 Gene ID: 9194.0 Gene Symbol: SLC16A7 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/26027796	Inhibitor 8504	4.1 µM [IC50]
Neuropeptide Y receptor type 5 10 Target ID: CHEMBL4561 Sources: https://www.ncbi.nlm.nih.gov/pubmed/15601626	Antagonist 2849	5.0 nM [IC50]
Nuclear receptor subfamily 1 group I member 3 9 Target ID: CHEMBL5503 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22044162	Inverse Agonist 85	0.7 µM [IC50]
Voltage-gated potassium channel subunit Kv1.5 43 Target ID: CHEMBL4306 Sources: https://www.ncbi.nlm.nih.gov/pubmed/11692231 \| https://www.ncbi.nlm.nih.gov/pubmed/17982261	Blocker 555	0.42 µM [IC50]
Alpha-2a adrenergic receptor 70 Target ID: CHEMBL1867 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22178752	Antagonist 2849	7.2 null [pKi]
Alpha-2b adrenergic receptor 35 Target ID: CHEMBL1942 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22178752	Antagonist 2849	8.2 null [pKi]
Alpha-2c adrenergic receptor 44 Target ID: CHEMBL1916 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22178752	Antagonist 2849	7.4 null [pKi]
Serotonin 2c (5-HT2c) receptor 131 Target ID: CHEMBL225 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22178752	Inverse Agonist 85	8.2 null [pKi]
Serotonin 2a (5-HT2a) receptor 237 Target ID: CHEMBL224 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22178752	Antagonist 2849	8.2 null [pKi]

Conditions

Condition	Modality	Highest Phase	Product
Ingrown toenails 5 Sources: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=895272f6-2644-4c38-b4b2-140616edb5d8	Palliative	Approved 8583	DR. SCHOLLS INGROWN TOENAIL PAIN RELIEVER Approved Use Use: - For temporary relief of pain and discomfort from ingrown toenails. Launch Date 2003
Unknown 2596
Arrhythmia 45 Sources: https://www.ncbi.nlm.nih.gov/pubmed/12382079 https://www.ncbi.nlm.nih.gov/pubmed/15232496	Primary	Preclinical	Unknown Approved Use Unknown
Depression 240 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22178753	Primary	Preclinical	Unknown Approved Use Unknown
Anxiety 275 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22178753	Primary	Preclinical	Unknown Approved Use Unknown
Cognition disorders 26 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22178753	Primary	Preclinical	Unknown Approved Use Unknown
Sleep disorder 25 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22178753	Primary	Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Kv1.5 blockers preferentially inhibit TASK-1 channels: TASK-1 as a target against atrial fibrillation and obstructive sleep apnea?	2015-05	25511502
Downregulation of cystathionine β-synthase/hydrogen sulfide contributes to rotenone-induced microglia polarization toward M1 type.	2014-08-22	25086357
H2S inhibition of chemical hypoxia-induced proliferation of HPASMCs is mediated by the upregulation of COX-2/PGI2.	2014-02	24337227
Dexamethasone ameliorates H₂S-induced acute lung injury by alleviating matrix metalloproteinase-2 and -9 expression.	2014	24722316
Sulfide induces apoptosis and Rho kinase-dependent cell blebbing in Jurkat cells.	2013-07	23479079
A novel mechanism of formaldehyde neurotoxicity: inhibition of hydrogen sulfide generation by promoting overproduction of nitric oxide.	2013	23359814
Indoor air pollutants and health in the United Arab Emirates.	2012-05	22357138
S32212, a novel serotonin type 2C receptor inverse agonist/α2-adrenoceptor antagonist and potential antidepressant: I. A mechanistic characterization.	2012-03	22178752
S32212, a novel serotonin type 2C receptor inverse agonist/α2-adrenoceptor antagonist and potential antidepressant: II. A behavioral, neurochemical, and electrophysiological characterization.	2012-03	22178753
New in vitro tools to study human constitutive androstane receptor (CAR) biology: discovery and comparison of human CAR inverse agonists.	2011-12-05	22044162
Detoxification of methylmercury by hydrogen sulfide-producing enzyme in Mammalian cells.	2011-10-17	21951228
S-Propargyl-cysteine (SPRC) attenuated lipopolysaccharide-induced inflammatory response in H9c2 cells involved in a hydrogen sulfide-dependent mechanism.	2011-06	21308383
Time-series analysis of mortality effects of fine particulate matter components in Detroit and Seattle.	2011-04	21193387
HIF-1 and SKN-1 coordinate the transcriptional response to hydrogen sulfide in Caenorhabditis elegans.	2011	21980473
Disulfides as cyanide antidotes: evidence for a new in vivo oxidative pathway for cyanide detoxification.	2009-12	19891443
Multiple protective activities of neuroglobin in cultured neuronal cells exposed to hypoxia re-oxygenation injury.	2009-03	19154338
Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder.	2008-02	18031925
Contractile and vasorelaxant effects of hydrogen sulfide and its biosynthesis in the human internal mammary artery.	2008-02	18029544
Emergency room visits for respiratory conditions in children increased after Guagua Pichincha volcanic eruptions in April 2000 in Quito, Ecuador observational study: time series analysis.	2007-07-24	17650330
Comparison of potent Kv1.5 potassium channel inhibitors reveals the molecular basis for blocking kinetics and binding mode.	2007	17982261
The third gas: H2S regulates perfusion pressure in both the isolated and perfused normal rat liver and in cirrhosis.	2005-09	16108046
Biochemical differentiation and comparison of Desulfovibrio species and other phenotypically similar genera.	2005-08	16081948
Induction of phase I, II and III drug metabolism/transport by xenobiotics.	2005-03	15832810
Major and trace elements in whole blood of phlebotomized patients with porphyria cutanea tarda.	2005	16325539
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.	2004-12-10	15520012
Atrial-selective antiarrhythmic actions of novel Ikur vs. Ikr, Iks, and IKAch class Ic drugs and beta blockers in pigs.	2004-07	15232496
A salivary incubation test for evaluation of oral malodor: a pilot study.	2003-07	12931755
Novel neural modulators.	2003	14527267
Electrophysiological and antiarrhythmic effects of the novel I(Kur) channel blockers, S9947 and S20951, on left vs. right pig atrium in vivo in comparison with the I(Kr) blockers dofetilide, azimilide, d,l-sotalol and ibutilide.	2002-11	12382079
Fatal and nonfatal poisoning by hydrogen sulfide at an industrial waste site.	2002-05	12051356
Liquid chromatography/tandem mass spectrometric bioanalysis using normal-phase columns with aqueous/organic mobile phases - a novel approach of eliminating evaporation and reconstitution steps in 96-well SPE.	2002	12362389
HG/LT-GC/ICP-MS coupling for identification of metal(loid) species in human urine after fish consumption.	2001-11	11767883
Characterization of a novel Kv1.5 channel blocker in Xenopus oocytes, CHO cells, human and rat cardiomyocytes.	2001-11	11692231
Hydrogen sulfide and colonic epithelial metabolism: implications for ulcerative colitis.	2001-08	11508674
Gas production by feces of infants.	2001-05	11429513
A fatal case of hydrogen sulfide poisoning in a geothermal power plant.	1998-07	9670519
The usefulness of thiosulfate as an indicator of hydrogen sulfide poisoning: three cases.	1997	9274948
Chemosensory event-related potentials in the investigation of interactions between the olfactory and the somatosensory (trigeminal) systems.	1992-09	1381671
Lung dysfunction in animal confinement workers--chairman's report to the Scientific Committee of the Third International Symposium: issues in health, safety and agriculture, held in Saskatoon, Saskatchewan, Canada, May 10-15, 1992.	1992	1362681
Activity of polymorphonuclear leukocytes in the presence of sulfide.	1989-09	2547720
Widespread occurrence of bacterial thiol methyltransferases and the biogenic emission of methylated sulfur gases.	1987-07	3662509
Clinical comparison of two radiocolloids for internal mammary lymphoscintigraphy.	1985-12	4067640
Convulsions following application of gamma benzene hexachloride.	1981-07	6168673
Investigations into black extrinsic tooth stain.	1977-08	270488

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

10-40 uM S07662 attenuates the phenytoin- and 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime (CITCO)-induced expression of CYP2B6 mRNA in human primary hepatocytes.

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:39:41 GMT 2025` Edited by `admin` on `Mon Mar 31 18:39:41 GMT 2025`
Record UNII	C02T02993U
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NATRUM SULPHURATUM

Preferred Name

English

SODIUM SULFIDE NONAHYDRATE

Common Name

English

SODIUM MONOSULPHIDE NONAHYDRATE

Common Name

English

SODIUM SULFIDE NONAHYDRATE [MI]

Common Name

English

SODIUM MONOSULFIDE NONAHYDRATE

Common Name

English

SODIUM SULFIDE [USP MONOGRAPH]

Common Name

English

NATRUM SULPHURATUM [HPUS]

Common Name

English

SODIUM SULPHIDE NONAHYDRATE

Common Name

English

Code System Code Type Description

PUBCHEM

73972