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Details

Stereochemistry ACHIRAL
Molecular Formula S
Molecular Weight 32.065
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge -2

SHOW SMILES / InChI
Structure of SULFIDE ION

SMILES

[S--]

InChI

InChIKey=UCKMPCXJQFINFW-UHFFFAOYSA-N
InChI=1S/S/q-2

HIDE SMILES / InChI
Molecular Formula H2S
Molecular Weight 34.081
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

A sulfide ion is composed of a lone sulfur atom. Its charge is negative two, giving sulfides this formula: S^2-. Sulfide is a strong base, so solutions of sulfide in water are basic, due to hydrolysis. One well-known ionic compound with a sulfide ion is H_2S. The infamous rotten-egg smell often associated with sulfur originates from this compound. Sodium sulfide nonahydrate is used in the formation of surface functionalized cadmium sulfide quantum dots.

CNS Activity

CNS Active
4002
Curator's Comment: S32212 is CNS active in animals. No human data available.

Originator

Approval Year

2003
181
Targets

Targets

Primary TargetPharmacologyConditionPotency
Sodium bicarbonate cotransporter 3
5
Target ID: Q9Y6M7|||B6DY53
Gene ID: 9497.0
Gene Symbol: SLC4A7
Target Organism: Homo sapiens (Human)
Inhibitor
8504
 1.7 µM [Ki]
Electrogenic sodium bicarbonate cotransporter 1
5
Target ID: Q9Y6R1|||Q9UP50
Gene ID: 8671.0
Gene Symbol: SLC4A4
Target Organism: Homo sapiens (Human)
Inhibitor
8504
 9.0 µM [IC50]
Malignant T-cell-amplified sequence 1
5
Target ID: Q9ULC4
Gene ID: 28985.0
Gene Symbol: MCTS1
Target Organism: Homo sapiens (Human)
Inhibitor
8504
 10.0 µM [IC50]
Monocarboxylate transporter 2
6
Target ID: O60669
Gene ID: 9194.0
Gene Symbol: SLC16A7
Target Organism: Homo sapiens (Human)
Inhibitor
8504
 4.1 µM [IC50]
Antagonist
2849
 5.0 nM [IC50]
Inverse Agonist
85
 0.7 µM [IC50]
Blocker
555
 0.42 µM [IC50]
Antagonist
2849
 7.2 null [pKi]
Antagonist
2849
 8.2 null [pKi]
Antagonist
2849
 7.4 null [pKi]
Inverse Agonist
85
 8.2 null [pKi]
Antagonist
2849
 8.2 null [pKi]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Approved
8583
DR. SCHOLLS INGROWN TOENAIL PAIN RELIEVER

Approved Use

Use: - For temporary relief of pain and discomfort from ingrown toenails.

Launch Date

2003
Primary
Preclinical
Unknown

Approved Use

Unknown
Primary
Preclinical
Unknown

Approved Use

Unknown
Primary
Preclinical
Unknown

Approved Use

Unknown
Primary
Preclinical
Unknown

Approved Use

Unknown
Primary
Preclinical
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Kv1.5 blockers preferentially inhibit TASK-1 channels: TASK-1 as a target against atrial fibrillation and obstructive sleep apnea?
2015-05
Downregulation of cystathionine β-synthase/hydrogen sulfide contributes to rotenone-induced microglia polarization toward M1 type.
2014-08-22
H2S inhibition of chemical hypoxia-induced proliferation of HPASMCs is mediated by the upregulation of COX-2/PGI2.
2014-02
Dexamethasone ameliorates H₂S-induced acute lung injury by alleviating matrix metalloproteinase-2 and -9 expression.
2014
Sulfide induces apoptosis and Rho kinase-dependent cell blebbing in Jurkat cells.
2013-07
A novel mechanism of formaldehyde neurotoxicity: inhibition of hydrogen sulfide generation by promoting overproduction of nitric oxide.
2013
Indoor air pollutants and health in the United Arab Emirates.
2012-05
S32212, a novel serotonin type 2C receptor inverse agonist/α2-adrenoceptor antagonist and potential antidepressant: I. A mechanistic characterization.
2012-03
S32212, a novel serotonin type 2C receptor inverse agonist/α2-adrenoceptor antagonist and potential antidepressant: II. A behavioral, neurochemical, and electrophysiological characterization.
2012-03
New in vitro tools to study human constitutive androstane receptor (CAR) biology: discovery and comparison of human CAR inverse agonists.
2011-12-05
Detoxification of methylmercury by hydrogen sulfide-producing enzyme in Mammalian cells.
2011-10-17
S-Propargyl-cysteine (SPRC) attenuated lipopolysaccharide-induced inflammatory response in H9c2 cells involved in a hydrogen sulfide-dependent mechanism.
2011-06
Time-series analysis of mortality effects of fine particulate matter components in Detroit and Seattle.
2011-04
HIF-1 and SKN-1 coordinate the transcriptional response to hydrogen sulfide in Caenorhabditis elegans.
2011
Disulfides as cyanide antidotes: evidence for a new in vivo oxidative pathway for cyanide detoxification.
2009-12
Multiple protective activities of neuroglobin in cultured neuronal cells exposed to hypoxia re-oxygenation injury.
2009-03
Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder.
2008-02
Contractile and vasorelaxant effects of hydrogen sulfide and its biosynthesis in the human internal mammary artery.
2008-02
Emergency room visits for respiratory conditions in children increased after Guagua Pichincha volcanic eruptions in April 2000 in Quito, Ecuador observational study: time series analysis.
2007-07-24
Comparison of potent Kv1.5 potassium channel inhibitors reveals the molecular basis for blocking kinetics and binding mode.
2007
The third gas: H2S regulates perfusion pressure in both the isolated and perfused normal rat liver and in cirrhosis.
2005-09
Biochemical differentiation and comparison of Desulfovibrio species and other phenotypically similar genera.
2005-08
Induction of phase I, II and III drug metabolism/transport by xenobiotics.
2005-03
Major and trace elements in whole blood of phlebotomized patients with porphyria cutanea tarda.
2005
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
2004-12-10
Atrial-selective antiarrhythmic actions of novel Ikur vs. Ikr, Iks, and IKAch class Ic drugs and beta blockers in pigs.
2004-07
A salivary incubation test for evaluation of oral malodor: a pilot study.
2003-07
Novel neural modulators.
2003
Electrophysiological and antiarrhythmic effects of the novel I(Kur) channel blockers, S9947 and S20951, on left vs. right pig atrium in vivo in comparison with the I(Kr) blockers dofetilide, azimilide, d,l-sotalol and ibutilide.
2002-11
Fatal and nonfatal poisoning by hydrogen sulfide at an industrial waste site.
2002-05
Liquid chromatography/tandem mass spectrometric bioanalysis using normal-phase columns with aqueous/organic mobile phases - a novel approach of eliminating evaporation and reconstitution steps in 96-well SPE.
2002
HG/LT-GC/ICP-MS coupling for identification of metal(loid) species in human urine after fish consumption.
2001-11
Characterization of a novel Kv1.5 channel blocker in Xenopus oocytes, CHO cells, human and rat cardiomyocytes.
2001-11
Hydrogen sulfide and colonic epithelial metabolism: implications for ulcerative colitis.
2001-08
Gas production by feces of infants.
2001-05
A fatal case of hydrogen sulfide poisoning in a geothermal power plant.
1998-07
The usefulness of thiosulfate as an indicator of hydrogen sulfide poisoning: three cases.
1997
Chemosensory event-related potentials in the investigation of interactions between the olfactory and the somatosensory (trigeminal) systems.
1992-09
Lung dysfunction in animal confinement workers--chairman's report to the Scientific Committee of the Third International Symposium: issues in health, safety and agriculture, held in Saskatoon, Saskatchewan, Canada, May 10-15, 1992.
1992
Activity of polymorphonuclear leukocytes in the presence of sulfide.
1989-09
Widespread occurrence of bacterial thiol methyltransferases and the biogenic emission of methylated sulfur gases.
1987-07
Clinical comparison of two radiocolloids for internal mammary lymphoscintigraphy.
1985-12
Convulsions following application of gamma benzene hexachloride.
1981-07
Investigations into black extrinsic tooth stain.
1977-08
Patents

Patents

03968062
5
04011225
6
04013678
7
04013769
12
04020170
5
04045520
5
04057647
16
04059433
6
8030332
5
WO2012066234A1
5
WO2012131379A1
5
WO2013116226A2
5
WO2015058053A1
5
WO2016180879A1
5
WO2016209929A1
5
WO2017007941A2
5
WO2017013031A1
5

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
10-40 uM S07662 attenuates the phenytoin- and 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime (CITCO)-induced expression of CYP2B6 mRNA in human primary hepatocytes.
Substance Class Chemical
Created
by admin
on Mon Mar 31 20:58:41 GMT 2025
Edited
by admin
on Mon Mar 31 20:58:41 GMT 2025
Record UNII
G15I91XETI
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SULFIDE ION
Common Name English
SULFIDE
Preferred Name English
SULFUR, ION (S2-)
Common Name English
SULPHIDE
Common Name English
SULPHIDE ION
Common Name English
Code System Code Type Description
DAILYMED
G15I91XETI
Created by admin on Mon Mar 31 20:58:41 GMT 2025 , Edited by admin on Mon Mar 31 20:58:41 GMT 2025
PRIMARY
RXCUI
1368379
Created by admin on Mon Mar 31 20:58:41 GMT 2025 , Edited by admin on Mon Mar 31 20:58:41 GMT 2025
PRIMARY RxNorm
CHEBI
15138
Created by admin on Mon Mar 31 20:58:41 GMT 2025 , Edited by admin on Mon Mar 31 20:58:41 GMT 2025
PRIMARY
SMS_ID
100000126196
Created by admin on Mon Mar 31 20:58:41 GMT 2025 , Edited by admin on Mon Mar 31 20:58:41 GMT 2025
PRIMARY
CHEBI
16136
Created by admin on Mon Mar 31 20:58:41 GMT 2025 , Edited by admin on Mon Mar 31 20:58:41 GMT 2025
PRIMARY
EPA CompTox
DTXSID20872928
Created by admin on Mon Mar 31 20:58:41 GMT 2025 , Edited by admin on Mon Mar 31 20:58:41 GMT 2025
PRIMARY
CHEBI
16385
Created by admin on Mon Mar 31 20:58:41 GMT 2025 , Edited by admin on Mon Mar 31 20:58:41 GMT 2025
PRIMARY
WIKIPEDIA
SULFIDE
Created by admin on Mon Mar 31 20:58:41 GMT 2025 , Edited by admin on Mon Mar 31 20:58:41 GMT 2025
PRIMARY
CAS
18496-25-8
Created by admin on Mon Mar 31 20:58:41 GMT 2025 , Edited by admin on Mon Mar 31 20:58:41 GMT 2025
PRIMARY
PUBCHEM
29109
Created by admin on Mon Mar 31 20:58:41 GMT 2025 , Edited by admin on Mon Mar 31 20:58:41 GMT 2025
PRIMARY
EVMPD
SUB32976
Created by admin on Mon Mar 31 20:58:41 GMT 2025 , Edited by admin on Mon Mar 31 20:58:41 GMT 2025
PRIMARY
FDA UNII
G15I91XETI
Created by admin on Mon Mar 31 20:58:41 GMT 2025 , Edited by admin on Mon Mar 31 20:58:41 GMT 2025
PRIMARY
Related Record Type Details
Structure of SULFIDE ION
ACTIVE MOIETY
NIH
NCATS
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ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
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