AMBAZONE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H11N7S
Molecular Weight	237.285
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of AMBAZONE

Structure Search

SMILES

NC(=N)NN=C1C=CC(C=C1)=NNC(N)=S

InChI

InChIKey=MLMFUKWWZIZRHX-UWRPRBHNSA-N

InChI=1S/C8H11N7S/c9-7(10)14-12-5-1-3-6(4-2-5)13-15-8(11)16/h1-4H,(H4,9,10,14)(H3,11,15,16)/b12-5-,13-6+

HIDE SMILES / InChI

Molecular Formula	C8H11N7S
Molecular Weight	237.285
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: https://www.rxdrugsafety.info/lek/54002,Faringosept-tabletki.html | https://www.ncbi.nlm.nih.gov/pubmed/2204445

Ambazone (1,4-benzoquinone guanylhydrazone thiosemicarbazone) is an antibacterial agent. It exerts antitumor activity both in vitro and in vivo. Ambazone is indicated in the treatment of infections of the mouth and throat, including tonsillitis, gingivitis, stomatitis, as well as after tonsillectomy, after tooth extraction.

Originator

Approval Year

PubMed

PubMed

Title	Date	PubMed
[Microbial sensitivity to ambazone (Faringosept) in pharyngeal samples from patients with acute infections of the upper respiratory tract].	2008-04-30	18441955

Patents

Patents

Sample Use Guides

In Vivo Use Guide

Faringosept (ambazone 10 mg). 3-5 tablets daily for 3-4 days. The tablets should be sucked slowly. The tablets should not be swallowed but allowed to slowly dissolve in the mouth. Use 15-30 minutes after a meal; after using the preparation, do not eat or drink fluids for 2-3 hours.

Route of Administration: Topical

Substance Class	Chemical Created by `admin` on `Wed Apr 02 09:29:40 GMT 2025` Edited by `admin` on `Wed Apr 02 09:29:40 GMT 2025`
Record UNII	BYK4592A3Q
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

AMBAZONE

Official Name

English

FARINGOSEPT

Preferred Name

English

ambazone [INN]

Common Name

English

AMBAZONE [MI]

Common Name

English

AMBAZONE [MART.]

Common Name

English

Ambazone [WHO-DD]

Common Name

English

HYDRAZINECARBOTHIOAMIDE, 2-(4-(2-(AMINOIMINOMETHYL)HYDRAZINYLIDENE)-2,5-CYCLOHEXADIEN-1-YLIDENE)-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C28394

Created by admin on Wed Apr 02 09:29:40 GMT 2025 , Edited by admin on Wed Apr 02 09:29:40 GMT 2025

NCI_THESAURUS

C274

Created by admin on Wed Apr 02 09:29:40 GMT 2025 , Edited by admin on Wed Apr 02 09:29:40 GMT 2025

WHO-VATC

QR02AA01

Created by admin on Wed Apr 02 09:29:40 GMT 2025 , Edited by admin on Wed Apr 02 09:29:40 GMT 2025

WHO-ATC

R02AA01

Created by admin on Wed Apr 02 09:29:40 GMT 2025 , Edited by admin on Wed Apr 02 09:29:40 GMT 2025

Code System Code Type Description

FDA UNII

BYK4592A3Q

Created by admin on Wed Apr 02 09:29:40 GMT 2025 , Edited by admin on Wed Apr 02 09:29:40 GMT 2025

PRIMARY

NCI_THESAURUS

C72627

Created by admin on Wed Apr 02 09:29:40 GMT 2025 , Edited by admin on Wed Apr 02 09:29:40 GMT 2025

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MERCK INDEX

m552

Created by admin on Wed Apr 02 09:29:40 GMT 2025 , Edited by admin on Wed Apr 02 09:29:40 GMT 2025

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Merck Index

EVMPD

SUB12841MIG

Created by admin on Wed Apr 02 09:29:40 GMT 2025 , Edited by admin on Wed Apr 02 09:29:40 GMT 2025

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MESH

C037931

Created by admin on Wed Apr 02 09:29:40 GMT 2025 , Edited by admin on Wed Apr 02 09:29:40 GMT 2025

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WIKIPEDIA

AMBAZONE

Created by admin on Wed Apr 02 09:29:40 GMT 2025 , Edited by admin on Wed Apr 02 09:29:40 GMT 2025

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DRUG BANK

DB13697

Created by admin on Wed Apr 02 09:29:40 GMT 2025 , Edited by admin on Wed Apr 02 09:29:40 GMT 2025

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CAS

539-21-9

Created by admin on Wed Apr 02 09:29:40 GMT 2025 , Edited by admin on Wed Apr 02 09:29:40 GMT 2025

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SMS_ID

100000077683

Created by admin on Wed Apr 02 09:29:40 GMT 2025 , Edited by admin on Wed Apr 02 09:29:40 GMT 2025

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EPA CompTox

DTXSID3046407

Created by admin on Wed Apr 02 09:29:40 GMT 2025 , Edited by admin on Wed Apr 02 09:29:40 GMT 2025

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DRUG CENTRAL

145

Created by admin on Wed Apr 02 09:29:40 GMT 2025 , Edited by admin on Wed Apr 02 09:29:40 GMT 2025

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ECHA (EC/EINECS)

208-713-0

Created by admin on Wed Apr 02 09:29:40 GMT 2025 , Edited by admin on Wed Apr 02 09:29:40 GMT 2025

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INN

822

Created by admin on Wed Apr 02 09:29:40 GMT 2025 , Edited by admin on Wed Apr 02 09:29:40 GMT 2025

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PUBCHEM

1549158

Created by admin on Wed Apr 02 09:29:40 GMT 2025 , Edited by admin on Wed Apr 02 09:29:40 GMT 2025

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ChEMBL

CHEMBL2103762

Created by admin on Wed Apr 02 09:29:40 GMT 2025 , Edited by admin on Wed Apr 02 09:29:40 GMT 2025

PRIMARY

Related Record Type Details


					37HWA5Q4FB

AMBAZONE MONOHYDRATE

SALT/SOLVATE -> PARENT


					37HWA5Q4FB

AMBAZONE MONOHYDRATE

SOLVATE->ANHYDROUS

Related Record Type Details


					BYK4592A3Q

AMBAZONE

ACTIVE MOIETY