AMBAZONE MONOHYDRATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H11N7S.H2O
Molecular Weight	255.3
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

O.NC(=N)NN=C1C=CC(C=C1)=NNC(N)=S

InChI

InChIKey=IEMLQLDCDHGTMI-IOHAXTJFSA-N

InChI=1S/C8H11N7S.H2O/c9-7(10)14-12-5-1-3-6(4-2-5)13-15-8(11)16;/h1-4H,(H4,9,10,14)(H3,11,15,16);1H2/b12-5-,13-6+;

HIDE SMILES / InChI

Molecular Formula	C8H11N7S
Molecular Weight	237.285
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Molecular Formula	H2O
Molecular Weight	18.0153
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.rxdrugsafety.info/lek/54002,Faringosept-tabletki.html | https://www.ncbi.nlm.nih.gov/pubmed/2204445

Ambazone (1,4-benzoquinone guanylhydrazone thiosemicarbazone) is an antibacterial agent. It exerts antitumor activity both in vitro and in vivo. Ambazone is indicated in the treatment of infections of the mouth and throat, including tonsillitis, gingivitis, stomatitis, as well as after tonsillectomy, after tooth extraction.

Originator

Approval Year

PubMed

Title	Date	PubMed
[Microbial sensitivity to ambazone (Faringosept) in pharyngeal samples from patients with acute infections of the upper respiratory tract].	2007 Jan-Jun	18441955

Patents

Sample Use Guides

In Vivo Use Guide

Faringosept (ambazone 10 mg). 3-5 tablets daily for 3-4 days. The tablets should be sucked slowly. The tablets should not be swallowed but allowed to slowly dissolve in the mouth. Use 15-30 minutes after a meal; after using the preparation, do not eat or drink fluids for 2-3 hours.

Route of Administration: Topical

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:20:08 GMT 2023` Edited by `admin` on `Fri Dec 15 18:20:08 GMT 2023`
Record UNII	37HWA5Q4FB
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

AMBAZONE MONOHYDRATE

Common Name

English

HYDRAZINECARBOTHIOAMIDE, 2-(4-(2-(AMINOIMINOMETHYL)HYDRAZINYLIDENE)-2,5-CYCLOHEXADIEN-1-YLIDENE)-, HYDRATE (1:1)

Systematic Name

English

Code System Code Type Description

SMS_ID

100000135407