OLUMACOSTAT

CCCCCCCCCCCCCCOC1=CC=C(O1)C(O)=O

InChIKey=CZRCFAOMWRAFIC-UHFFFAOYSA-N

InChI=1S/C19H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22-18-15-14-17(23-18)19(20)21/h14-15H,2-13,16H2,1H3,(H,20,21)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Condition	Potency
Acetyl-CoA carboxylase 1 5 Target ID: CHEMBL3351 Sources: https://www.ncbi.nlm.nih.gov/pubmed/23732836\|https://www.ncbi.nlm.nih.gov/pubmed/21525791	Inhibitor 8297
Acetyl-CoA carboxylase 3 Target ID: Acetyl-CoA carboxylase Sources: https://adisinsight.springer.com/drugs/800038781 \| https://www.ncbi.nlm.nih.gov/pubmed/28029390	Inhibitor 8297

PubMed

Title	Date	PubMed
Oily Skin: A review of Treatment Options.	2017 Aug	28979664
Olumacostat glasaretil, a novel topical sebum inhibitor, in the treatment of acne vulgaris: A phase IIa, multicenter, randomized, vehicle-controlled study.	2017 Jan	28029390
Anti-acne drugs in phase 1 and 2 clinical trials.	2017 Jul	28627277
Inhibition of Sebum Production with the Acetyl Coenzyme A Carboxylase Inhibitor Olumacostat Glasaretil.	2017 Jul	28259683
From pathogenesis of acne vulgaris to anti-acne agents.	2019 Jul	30859308

Substance Class	Chemical Created by `admin` on `Sat Dec 16 08:35:15 GMT 2023` Edited by `admin` on `Sat Dec 16 08:35:15 GMT 2023`
Record UNII	BI12FRY055
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

OLUMACOSTAT

Common Name

English

RMI-14514

Common Name

English

RMI 14,514

Code

English

5-(TETRADECYLOXY)-2-FURANCARBOXYLIC ACID

Systematic Name

English

TOFA

Common Name

English

RMI-14,514

Code

English

5-(TETRADECYLOXY)-2-FUROIC ACID

Systematic Name

English

Code System Code Type Description

CHEBI

77936