OLUMACOSTAT GLASARETIL

Details

Stereochemistry	ACHIRAL
Molecular Formula	C26H43NO7
Molecular Weight	481.6221
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCCCCCCCCCCCOC1=CC=C(O1)C(=O)OCC(=O)N(C)CC(=O)OCC

InChI

InChIKey=FYJLDICZGDFWKP-UHFFFAOYSA-N

InChI=1S/C26H43NO7/c1-4-6-7-8-9-10-11-12-13-14-15-16-19-32-25-18-17-22(34-25)26(30)33-21-23(28)27(3)20-24(29)31-5-2/h17-18H,4-16,19-21H2,1-3H3

HIDE SMILES / InChI

Molecular Formula	C26H43NO7
Molecular Weight	481.6221
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Acetyl-CoA carboxylase 1 5 Target ID: CHEMBL3351 Sources: https://www.ncbi.nlm.nih.gov/pubmed/23732836\|https://www.ncbi.nlm.nih.gov/pubmed/21525791	Inhibitor 8297
Acetyl-CoA carboxylase 3 Target ID: Acetyl-CoA carboxylase Sources: https://adisinsight.springer.com/drugs/800038781 \| https://www.ncbi.nlm.nih.gov/pubmed/28029390	Inhibitor 8297

PubMed

Title	Date	PubMed
Oily Skin: A review of Treatment Options.	2017 Aug	28979664
Olumacostat glasaretil, a novel topical sebum inhibitor, in the treatment of acne vulgaris: A phase IIa, multicenter, randomized, vehicle-controlled study.	2017 Jan	28029390
Anti-acne drugs in phase 1 and 2 clinical trials.	2017 Jul	28627277
Inhibition of Sebum Production with the Acetyl Coenzyme A Carboxylase Inhibitor Olumacostat Glasaretil.	2017 Jul	28259683
From pathogenesis of acne vulgaris to anti-acne agents.	2019 Jul	30859308

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:56:37 GMT 2023` Edited by `admin` on `Fri Dec 15 15:56:37 GMT 2023`
Record UNII	4W6JDK2PLY
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

OLUMACOSTAT GLASARETIL

Official Name

English

DRM01B

Code

English

DRM-01B

Code

English

2-FURANCARBOXYLIC ACID, 5-(TETRADECYLOXY)-, 2-((2-ETHOXY-2-OXOETHYL)METHYLAMINO)-2-OXOETHYL ESTER

Systematic Name

English

Olumacostat glasaretil [WHO-DD]

Common Name

English

olumacostat glasaretil [INN]

Common Name

English

2-[(2-Ethoxy-2-oxoethyl)methylamino]-2-oxoethyl 5-(tetradecyloxy)furan-2-carboxylate

Systematic Name

English

OLUMACOSTAT GLASARETIL [USAN]

Common Name

English

Code System Code Type Description

USAN

DE-161