ANDEXANET ALFA

Approval Year

Substance Class	Protein
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	BI009E452R
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

COAGULATION FACTOR XA (RECOMBINANT), INACTIVATED-ZHZO

Preferred Name

English

ANDEXANET ALFA

Official Name

English

PRT064445

Code

English

PRT-064445

Code

English

ANDEXANET ALFA [USAN]

Common Name

English

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Classification Tree

Code System

Code

Designated/Approved

FDA ORPHAN DRUG

437414

Antidotes

WHO-ATC

V03AB38

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Code System

Code

Type

Description

SMS_ID

100000166815

PRIMARY

DAILYMED

BI009E452R

PRIMARY

USAN

BC-65

PRIMARY

RXCUI

2045114

PRIMARY

FDA UNII

BI009E452R

PRIMARY

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Subunit 0

Subunit 1

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From	To
1_7	1_12
1_27	1_43
1_108	2_98
1_156	1_170
1_181	1_209

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Glycosylation Link Type	Site
O	1_82
O	1_249
O	2_56
O	2_72

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Related Record

Type

Details


					BI009E452R

ANDEXANET ALFA

ACTIVE MOIETY

Comments:

PRT064445 has high affinity for small molecule fXa inhibitors

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Structural Modifications

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Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[2_29]		Asp		.BETA.-HYDROXY-L-ASPARTIC ACID, THREO-	Z9Q5W0U8VW

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Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL	ESTIMATED 40100 Da (average)
Molecular Formula	CHEMICAL	ESTIMATED C1750H2717N489O542S27

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