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Details

Stereochemistry ABSOLUTE
Molecular Formula C4H7NO5
Molecular Weight 149.1021
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of .BETA.-HYDROXY-L-ASPARTIC ACID, THREO-

SMILES

N[C@@H]([C@H](O)C(O)=O)C(O)=O

InChI

InChIKey=YYLQUHNPNCGKJQ-LWMBPPNESA-N
InChI=1S/C4H7NO5/c5-1(3(7)8)2(6)4(9)10/h1-2,6H,5H2,(H,7,8)(H,9,10)/t1-,2-/m0/s1

HIDE SMILES / InChI

Molecular Formula C4H7NO5
Molecular Weight 149.1021
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

L-threo-beta-hydroxyaspartic acid or β-hydroxy-L- aspartic acid is a glutamate uptake inhibitor and possesses antimicrobial activity against various microorganisms.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
Antiallodynic effect of herbal medicine yokukansan on peripheral neuropathy in rats with chronic constriction injury.
2012
Viral-induced spinal motor neuron death is non-cell-autonomous and involves glutamate excitotoxicity.
2004-08-25
Glutamate transport blockade has a differential effect on AMPA and NMDA receptor-mediated synaptic transmission in the developing barrel cortex.
2000-03-03
(2S,3S,4R)-2-(carboxycyclopropyl)glycine, a potent and competitive inhibitor of both glial and neuronal uptake of glutamate.
1993-09
Neurotoxicity of L-glutamate and DL-threo-3-hydroxyaspartate in the rat striatum.
1985-01
Potentiation of L-glutamate and L-aspartate excitation of cat spinal neurones by the stereoisomers of threo-3-hydroxyaspartate.
1980-01

Sample Use Guides

toxicity in mice: 25 mg/kg
Route of Administration: Intravenous
In Vitro Use Guide
L-threo-beta-hydroxyaspartic acid (range of concentrations: 31.25; 62.5; 125; 250; 500 ug/mL) shows inhibitory activity against some bacterias
Substance Class Chemical
Created
by admin
on Mon Mar 31 20:48:49 GMT 2025
Edited
by admin
on Mon Mar 31 20:48:49 GMT 2025
Record UNII
Z9Q5W0U8VW
Record Status Validated (UNII)
Record Version
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Name Type Language
.BETA.-HYDROXY-L-ASPARTIC ACID, THREO-
Common Name English
.BETA.-HYDROXYASPARTIC ACID, L-THREO-
Preferred Name English
L-ASPARTIC ACID, 3-HYDROXY-, (3S)-
Common Name English
NSC-139979
Code English
L-THREO-.BETA.-HYDROXYASPARTIC ACID
Common Name English
Code System Code Type Description
CAS
7298-99-9
Created by admin on Mon Mar 31 20:48:49 GMT 2025 , Edited by admin on Mon Mar 31 20:48:49 GMT 2025
PRIMARY
FDA UNII
Z9Q5W0U8VW
Created by admin on Mon Mar 31 20:48:49 GMT 2025 , Edited by admin on Mon Mar 31 20:48:49 GMT 2025
PRIMARY
NSC
139979
Created by admin on Mon Mar 31 20:48:49 GMT 2025 , Edited by admin on Mon Mar 31 20:48:49 GMT 2025
PRIMARY
PUBCHEM
443239
Created by admin on Mon Mar 31 20:48:49 GMT 2025 , Edited by admin on Mon Mar 31 20:48:49 GMT 2025
PRIMARY
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