.BETA.-HYDROXY-L-ASPARTIC ACID, THREO-

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C4H7NO5
Molecular Weight	149.1021
Optical Activity	UNSPECIFIED
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of .BETA.-HYDROXY-L-ASPARTIC ACID, THREO-

Structure Search

SMILES

N[C@@H]([C@H](O)C(O)=O)C(O)=O

InChI

InChIKey=YYLQUHNPNCGKJQ-LWMBPPNESA-N

InChI=1S/C4H7NO5/c5-1(3(7)8)2(6)4(9)10/h1-2,6H,5H2,(H,7,8)(H,9,10)/t1-,2-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C4H7NO5
Molecular Weight	149.1021
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/10699439 | https://www.ncbi.nlm.nih.gov/pubmed/1237486/

L-threo-beta-hydroxyaspartic acid or β-hydroxy-L- aspartic acid is a glutamate uptake inhibitor and possesses antimicrobial activity against various microorganisms.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
L-glutamate transport 2 Target ID: GO:0015813 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22454692	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

Title	Date	PubMed
Glutamate transport blockade has a differential effect on AMPA and NMDA receptor-mediated synaptic transmission in the developing barrel cortex.	2000 Mar 3	10699439

Sample Use Guides

In Vivo Use Guide

toxicity in mice: 25 mg/kg

Route of Administration: Intravenous

In Vitro Use Guide

L-threo-beta-hydroxyaspartic acid (range of concentrations: 31.25; 62.5; 125; 250; 500 ug/mL) shows inhibitory activity against some bacterias

Substance Class	Chemical Created by `admin` on `Sat Dec 16 01:22:20 GMT 2023` Edited by `admin` on `Sat Dec 16 01:22:20 GMT 2023`
Record UNII	Z9Q5W0U8VW
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

.BETA.-HYDROXY-L-ASPARTIC ACID, THREO-

Common Name

English

L-ASPARTIC ACID, 3-HYDROXY-, (3S)-

Common Name

English

NSC-139979

Code

English

L-THREO-.BETA.-HYDROXYASPARTIC ACID

Common Name

English

.BETA.-HYDROXYASPARTIC ACID, L-THREO-

Common Name

English

Code System Code Type Description

CAS

7298-99-9

Created by admin on Sat Dec 16 01:22:20 GMT 2023 , Edited by admin on Sat Dec 16 01:22:20 GMT 2023

PRIMARY

FDA UNII

Z9Q5W0U8VW

Created by admin on Sat Dec 16 01:22:20 GMT 2023 , Edited by admin on Sat Dec 16 01:22:20 GMT 2023

PRIMARY

NSC

139979

Created by admin on Sat Dec 16 01:22:20 GMT 2023 , Edited by admin on Sat Dec 16 01:22:20 GMT 2023

PRIMARY

PUBCHEM

443239

Created by admin on Sat Dec 16 01:22:20 GMT 2023 , Edited by admin on Sat Dec 16 01:22:20 GMT 2023

PRIMARY

Related Record Type Details


					99A78V5YX2

.BETA.-HYDROXY-DL-ASPARTIC ACID

RACEMATE -> ENANTIOMER

Amount:

Details

SMILES

InChI

DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/10699439 | https://www.ncbi.nlm.nih.gov/pubmed/1237486/

Approval Year

Targets

Conditions

PubMed

Sample Use Guides

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/10699439 | https://www.ncbi.nlm.nih.gov/pubmed/1237486/