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Details

Stereochemistry ABSOLUTE
Molecular Formula C4H7NO5
Molecular Weight 149.1021
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of .BETA.-HYDROXY-L-ASPARTIC ACID, THREO-

SMILES

N[C@@H]([C@H](O)C(O)=O)C(O)=O

InChI

InChIKey=YYLQUHNPNCGKJQ-LWMBPPNESA-N
InChI=1S/C4H7NO5/c5-1(3(7)8)2(6)4(9)10/h1-2,6H,5H2,(H,7,8)(H,9,10)/t1-,2-/m0/s1

HIDE SMILES / InChI
Molecular Formula C4H7NO5
Molecular Weight 149.1021
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

L-threo-beta-hydroxyaspartic acid or β-hydroxy-L- aspartic acid is a glutamate uptake inhibitor and possesses antimicrobial activity against various microorganisms.

Approval Year

Unknown
149124
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8504
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
(2S,3S,4R)-2-(carboxycyclopropyl)glycine, a potent and competitive inhibitor of both glial and neuronal uptake of glutamate.
1993 Sep

Sample Use Guides

In Vivo Use Guide
toxicity in mice: 25 mg/kg
Route of Administration: Intravenous
In Vitro Use Guide
L-threo-beta-hydroxyaspartic acid (range of concentrations: 31.25; 62.5; 125; 250; 500 ug/mL) shows inhibitory activity against some bacterias
Substance Class Chemical
Created
by admin
on Mon Mar 31 20:48:49 GMT 2025
Edited
by admin
on Mon Mar 31 20:48:49 GMT 2025
Record UNII
Z9Q5W0U8VW
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
.BETA.-HYDROXY-L-ASPARTIC ACID, THREO-
Common Name English
.BETA.-HYDROXYASPARTIC ACID, L-THREO-
Preferred Name English
L-ASPARTIC ACID, 3-HYDROXY-, (3S)-
Common Name English
NSC-139979
Code English
L-THREO-.BETA.-HYDROXYASPARTIC ACID
Common Name English
Code System Code Type Description
CAS
7298-99-9
Created by admin on Mon Mar 31 20:48:49 GMT 2025 , Edited by admin on Mon Mar 31 20:48:49 GMT 2025
PRIMARY
FDA UNII
Z9Q5W0U8VW
Created by admin on Mon Mar 31 20:48:49 GMT 2025 , Edited by admin on Mon Mar 31 20:48:49 GMT 2025
PRIMARY
NSC
139979
Created by admin on Mon Mar 31 20:48:49 GMT 2025 , Edited by admin on Mon Mar 31 20:48:49 GMT 2025
PRIMARY
PUBCHEM
443239
Created by admin on Mon Mar 31 20:48:49 GMT 2025 , Edited by admin on Mon Mar 31 20:48:49 GMT 2025
PRIMARY
Related Record Type Details
Structure of .BETA.-HYDROXY-DL-ASPARTIC ACID
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