Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C4H7NO5 |
| Molecular Weight | 149.1021 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
N[C@@H]([C@H](O)C(O)=O)C(O)=O
InChI
InChIKey=YYLQUHNPNCGKJQ-LWMBPPNESA-N
InChI=1S/C4H7NO5/c5-1(3(7)8)2(6)4(9)10/h1-2,6H,5H2,(H,7,8)(H,9,10)/t1-,2-/m0/s1
| Molecular Formula | C4H7NO5 |
| Molecular Weight | 149.1021 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 2 / 2 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: GO:0015813 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22454692 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
PubMed
| Title | Date | PubMed |
|---|---|---|
| Antiallodynic effect of herbal medicine yokukansan on peripheral neuropathy in rats with chronic constriction injury. | 2012 |
|
| Viral-induced spinal motor neuron death is non-cell-autonomous and involves glutamate excitotoxicity. | 2004-08-25 |
|
| Glutamate transport blockade has a differential effect on AMPA and NMDA receptor-mediated synaptic transmission in the developing barrel cortex. | 2000-03-03 |
|
| (2S,3S,4R)-2-(carboxycyclopropyl)glycine, a potent and competitive inhibitor of both glial and neuronal uptake of glutamate. | 1993-09 |
|
| Neurotoxicity of L-glutamate and DL-threo-3-hydroxyaspartate in the rat striatum. | 1985-01 |
|
| Potentiation of L-glutamate and L-aspartate excitation of cat spinal neurones by the stereoisomers of threo-3-hydroxyaspartate. | 1980-01 |
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1237486
toxicity in mice: 25 mg/kg
Route of Administration:
Intravenous
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1237486
L-threo-beta-hydroxyaspartic acid (range of concentrations: 31.25; 62.5; 125; 250; 500 ug/mL) shows inhibitory activity against some bacterias
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 20:48:49 GMT 2025
by
admin
on
Mon Mar 31 20:48:49 GMT 2025
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| Record UNII |
Z9Q5W0U8VW
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| Record Status |
Validated (UNII)
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| Related Record | Type | Details | ||
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RACEMATE -> ENANTIOMER |
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