Hydrogen peroxide

Details

Stereochemistry	ACHIRAL
Molecular Formula	H2O2
Molecular Weight	34.0147
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

OO

InChI

InChIKey=MHAJPDPJQMAIIY-UHFFFAOYSA-N

InChI=1S/H2O2/c1-2/h1-2H

HIDE SMILES / InChI

Molecular Formula	H2O2
Molecular Weight	34.0147
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description

Hydrogen peroxide has been used in medicine for more than 100 years. It is known in surgery as a highly useful irrigation solution by virtue of both its hemostatic and its antimicrobial effects. Hydrogen peroxide is a mild antiseptic used on the skin to prevent infection of minor cuts, scrapes, and burns. It may also be used as a mouth rinse to help remove mucus or to relieve minor mouth irritation (e.g., due to canker/cold sores, gingivitis). This product works by releasing oxygen when it is applied to the affected area. The release of oxygen causes foaming, which helps to remove dead skin and clean the area. Hydrogen peroxide is a strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
oxidoreductase activity 4	Modulator 846
Transient receptor potential cation channel subfamily M member 2 7	Agonist 2,752		4.54 null [pEC50]

Conditions

Condition	Modality	Highest Phase	Product
Seborrheic keratoses 4	Primary	Approved 8,583	ESKATA
Skin infections 59	Preventing	Approved 8,583	Hydrogen Peroxide Solution
Gingivitis 45	Primary	Approved 8,583	Hydrogen Peroxide Solution

PubMed

Show entries

Title	Date	PubMed
Myeloperoxidase exerts microbicidal activity against Mycobacterium tuberculosis.	1999 Aug	10417186
Critical role of sulfenic acid formation of thiols in the inactivation of glyceraldehyde-3-phosphate dehydrogenase by nitric oxide.	1999 Jul 1	10403526
Oxidative stress triggers STAT3 tyrosine phosphorylation and nuclear translocation in human lymphocytes.	1999 Jun 18	10364193
Prevention of Kupffer cell-induced oxidant injury in rat liver by atrial natriuretic peptide.	1999 May	10330004
Inhibition of glomerular cell apoptosis by heparin.	1999 Sep	10469363

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Sample Use Guides

In Vivo Use Guide

Topical solution: 40% (w/w) hydrogen peroxide. Apply 4 times, approximately 1 minute apart, to the targeted lesion(s) during a single in-office treatment session.

Route of Administration: Topical

In Vitro Use Guide

Hydrogen peroxide (H2O2, 100-500 uM) caused a concentration-dependent decrease in the activity of recombinant mouse 3-MST enzyme. In mitochondria isolated from murine hepatoma cells, H2O2 (50-500 uM) caused a concentration-dependent decrease in production of H2S from 3-MP. In cultured murine hepatoma cells H2O2, (3-100 uM), did not result in overall cytotoxicity, but caused a partial decrease in basal oxygen consumption and respiratory reserve rapacity. The positive bioenergetic effect of 3-MP (100-300 nM) was completely abolished by pre-treatment of the cells with H2O2 (50 uM).