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Details

Stereochemistry ACHIRAL
Molecular Formula H2O2
Molecular Weight 34.0147
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of Hydrogen peroxide

SMILES

OO

InChI

InChIKey=MHAJPDPJQMAIIY-UHFFFAOYSA-N
InChI=1S/H2O2/c1-2/h1-2H

HIDE SMILES / InChI

Molecular Formula H2O2
Molecular Weight 34.0147
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Hydrogen peroxide has been used in medicine for more than 100 years. It is known in surgery as a highly useful irrigation solution by virtue of both its hemostatic and its antimicrobial effects. Hydrogen peroxide is a mild antiseptic used on the skin to prevent infection of minor cuts, scrapes, and burns. It may also be used as a mouth rinse to help remove mucus or to relieve minor mouth irritation (e.g., due to canker/cold sores, gingivitis). This product works by releasing oxygen when it is applied to the affected area. The release of oxygen causes foaming, which helps to remove dead skin and clean the area. Hydrogen peroxide is a strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.

CNS Activity

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
4.54 null [pEC50]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
ESKATA
Preventing
Hydrogen Peroxide Solution
Primary
Hydrogen Peroxide Solution

PubMed

Sample Use Guides

In Vivo Use Guide
Topical solution: 40% (w/w) hydrogen peroxide. Apply 4 times, approximately 1 minute apart, to the targeted lesion(s) during a single in-office treatment session.
Route of Administration: Topical
In Vitro Use Guide
Hydrogen peroxide (H2O2, 100-500 uM) caused a concentration-dependent decrease in the activity of recombinant mouse 3-MST enzyme. In mitochondria isolated from murine hepatoma cells, H2O2 (50-500 uM) caused a concentration-dependent decrease in production of H2S from 3-MP. In cultured murine hepatoma cells H2O2, (3-100 uM), did not result in overall cytotoxicity, but caused a partial decrease in basal oxygen consumption and respiratory reserve rapacity. The positive bioenergetic effect of 3-MP (100-300 nM) was completely abolished by pre-treatment of the cells with H2O2 (50 uM).
Substance Class Chemical
Record UNII
BBX060AN9V
Record Status Validated (UNII)
Record Version