SULFORIDAZINE

Possibly Marketed Outside US

Details

Stereochemistry	RACEMIC
Molecular Formula	C21H26N2O2S2
Molecular Weight	402.573
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1CCCCC1CCN2C3=CC(=CC=C3SC4=C2C=CC=C4)S(C)(=O)=O

InChI

InChIKey=FLGCRGJDQJIJAW-UHFFFAOYSA-N

InChI=1S/C21H26N2O2S2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)26-21-11-10-17(15-19(21)23)27(2,24)25/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C21H26N2O2S2
Molecular Weight	402.573
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1839 | https://www.ncbi.nlm.nih.gov/pubmed/2600782 | https://www.ncbi.nlm.nih.gov/pubmed/2746491 | https://www.ncbi.nlm.nih.gov/pubmed/8097899 | https://www.drugfuture.com/chemdata/sulforidazine.html

Sulforidazine (Imagotan (Sandoz); Inofal (Sandoz)) is a typical piperidine-type phenothiazine antipsychotic agent. It is dopamine receptor blocker. Being the second active metabolite of thioridazine (converted from mesoridazine), Sulforidazine is significantly more potent than the parent drug.

Approval Year

PubMed

Title	Date	PubMed
Effect of thioridazine dosage on the debrisoquine hydroxylation phenotype in psychiatric patients with different CYP2D6 genotypes.	2001 Dec	11802093
Thioridazine steady-state plasma concentrations are influenced by tobacco smoking and CYP2D6, but not by the CYP2C9 genotype.	2003 May	12682803
Using absolute and relative reasoning in the prediction of the potential metabolism of xenobiotics.	2003 Sep-Oct	14502469
No effect of the CYP1A2*1F genotype on thioridazine, mesoridazine, sulforidazine plasma concentrations in psychiatric patients.	2007 May	17345072
Factors affecting drug concentrations and QT interval during thioridazine therapy.	2007 Nov	17460606

Sample Use Guides

In Vivo Use Guide

The metabolism of sulforidazine was studied in female dogs and adult male humans after oral administration of 37.5 mg and 25.0 mg, respectively.

Route of Administration: Oral

In Vitro Use Guide

Mesoridazine and sulforidazine likewise produced only small increases (5-20%) in evoked overflow of DA from slices stimulated at 0.3 Hz. At this frequency of stimulation, apomorphine (30 nM) inhibited the overflow of DA by 71.4 +/- 8.43% (n = 40). All three drugs antagonized, in a concentration-dependent fashion, the inhibitory effect of apomorphine (30 nM) on electrically evoked DA release at 0.3 Hz. The IC50 for thioridazine for antagonizing the effect of apomorphine was 130 nM, whereas that for mesoridazine was 14.4 nM and for sulforidazine was 6.1 nM.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:18:05 GMT 2023` Edited by `admin` on `Fri Dec 15 15:18:05 GMT 2023`
Record UNII	B7599I244X
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SULFORIDAZINE

Official Name

English

TPN-12

Code

English

2-METHYLSULFONYL-10-(2-(1-METHYL-2-PIPERIDYL)ETHYL)PHENOTHIAZINE

Systematic Name

English

10H-PHENOTHIAZINE, 10-(2-(1-METHYL-2-PIPERIDINYL)ETHYL)-2-(METHYLSULFONYL)-

Systematic Name

English

PSYCHOSON

Brand Name

English

IMAGOTAN

Brand Name

English

SULFORIDAZINE [MI]

Common Name

English

THIORIDAZINE HYDROCHLORIDE IMPURITY E [EP IMPURITY]

Common Name

English

INOFAL

Brand Name

English

PHENOTHIAZINE, 10-(2-(1-METHYL-2-PIPERIDYL)ETHYL)-2-(METHYLSULFONYL)-

Systematic Name

English

sulforidazine [INN]

Common Name

English

10-(2-(1-METHYL-2-PIPERIDYL)ETHYL)-2-METHYLSULFONYLPHENOTHIAZINE

Systematic Name

English

THIORIDAZINE SULFONE

Common Name

English

10-(2-(1-METHYL-2-PIPERIDINYL)ETHYL)-2-(METHYLSULFONYL)-10H-PHENOTHIAZINE

Systematic Name

English

THIORIDAZINE IMPURITY E [EP IMPURITY]

Common Name

English

Sulforidazine [WHO-DD]

Common Name

English

THIORIDAZINE-2-SULFONE

Common Name

English

THIORIDAZINE SULPHONE

Common Name

English

SULFORIDAZINE [MART.]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29710