Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C24H31FN2 |
| Molecular Weight | 366.5147 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
FC1=C(C=CC=C1)C(CC2=CC=CC=C2)N3CCN(CC3)C4CCCCC4
InChI
InChIKey=BZESPHAKQKJBSM-UHFFFAOYSA-N
InChI=1S/C24H31FN2/c25-23-14-8-7-13-22(23)24(19-20-9-3-1-4-10-20)27-17-15-26(16-18-27)21-11-5-2-6-12-21/h1,3-4,7-10,13-14,21,24H,2,5-6,11-12,15-19H2
| Molecular Formula | C24H31FN2 |
| Molecular Weight | 366.5147 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Wed Apr 02 12:21:38 GMT 2025
by
admin
on
Wed Apr 02 12:21:38 GMT 2025
|
| Record UNII |
B5PQ8A33Q9
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
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Code | English | ||
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Preferred Name | English | ||
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Systematic Name | English |
| Classification Tree | Code System | Code | ||
|---|---|---|---|---|
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CDC |
2-fluoro MT-45
Created by
admin on Wed Apr 02 12:21:38 GMT 2025 , Edited by admin on Wed Apr 02 12:21:38 GMT 2025
|
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
B5PQ8A33Q9
Created by
admin on Wed Apr 02 12:21:38 GMT 2025 , Edited by admin on Wed Apr 02 12:21:38 GMT 2025
|
PRIMARY | |||
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132990975
Created by
admin on Wed Apr 02 12:21:38 GMT 2025 , Edited by admin on Wed Apr 02 12:21:38 GMT 2025
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
TARGET -> AGONIST |
??arrestin2 recruitment
EC50
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SALT/SOLVATE -> PARENT |
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TARGET -> AGONIST |
The fluorinated MT?45 derivatives have higher apparent potencies (2F?MT?45: 42 nM) than MT?45 (1.3 ?M) for inhibition of cAMP accumulation and ??arrestin2 recruitment (2F?MT?45: 196 nM; MT?45: 23.1 ?M).
EC50
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||
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|
TARGET -> AGONIST |
??arrestin2 recruitment
|
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
ACTIVE MOIETY |
|
