DINITOLMIDE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H7N3O5
Molecular Weight	225.1583
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=C(C=C(C=C1[N+]([O-])=O)[N+]([O-])=O)C(N)=O

InChI

InChIKey=ZEFNOZRLAWVAQF-UHFFFAOYSA-N

InChI=1S/C8H7N3O5/c1-4-6(8(9)12)2-5(10(13)14)3-7(4)11(15)16/h2-3H,1H3,(H2,9,12)

HIDE SMILES / InChI

Molecular Formula	C8H7N3O5
Molecular Weight	225.1583
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.zoetisus.com/contact/pages/product_information/msds_pi/pi/zoamix.pdf
Curator's Comment: description was created based on several sources, including, http://nj.gov/health/eoh/rtkweb/documents/fs/0775.pdf

Dinitolmide (also known as zoalene) is a nitrobenzamide coccidiostat developed by Dow Company. The drug is approved by FDA for the prevention and control of coccidiosis in chickens and turkeys. Dinitolmide is hazardous for man as it may cause mutations. Thus the substance should be handle with extreme caution.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Coccidiosis 45 Sources: https://www.zoetisus.com/contact/pages/product_information/msds_pi/pi/zoamix.pdf	Preventing		Approved 8583	ZOAMIX Approved Use For prevention and control of coccidiosis. Launch Date 2001

Overview

CYP3A4	CYP2C9	CYP2D6	hERG
inducer 1087 activator 150 inhibitor 2252	inhibitor 2438	inhibitor 2507	inhibitor 2217

OverviewOther

Other Inhibitor	Other Substrate	Other Inducer
OATP1B3 961 CYP19A1 429 CYP2C19 2057 OATP1B1 1079 CYP1A2 2153 P-gp 1741 UMAT 30

Drug as perpetrator

Target	Modality	Activity
CYP1A2 2333	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/bioassay/1671199#sid=144211637	inconclusive [IC50 35.5742 uM]
CYP19A1 430	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/bioassay/743083#sid=144204927	no
CYP2C19 2141	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/bioassay/1671197#sid=144211637	no
CYP2C9 2497	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/bioassay/1645842#sid=170465727	no
CYP2D6 2546	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/bioassay/1645840#sid=170465727	no
CYP3A4 2633	activator 342 Sources: https://pubchem.ncbi.nlm.nih.gov/bioassay/885#sid=26748665	no
CYP3A4 2633	inducer 1966 Sources: https://pubchem.ncbi.nlm.nih.gov/bioassay/1346984#sid=144204927	no
CYP3A4 2633	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/bioassay/884#sid=26748665	no
P-gp 1932	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/bioassay/1347076#sid=89854490	no
UMAT 30	inhibitor 4027 Sources: https://pubchem.ncbi.nlm.nih.gov/bioassay/602162#sid=89854490	no
OATP1B1 1095	inhibitor 4027 Sources: https://pubmed.ncbi.nlm.nih.gov/23571415/	yes [Inhibition 10 uM]
OATP1B3 970	inhibitor 4027 Sources: https://pubmed.ncbi.nlm.nih.gov/23571415/	yes [Inhibition 10 uM]

Tox targets

Target	Modality	Activity	Metabolite	Clinical evidence
hERG 2263	inhibitor 2237 Sources: https://pubchem.ncbi.nlm.nih.gov/bioassay/588834#sid=144204927

PubMed

Title	Date	PubMed
Efficacy of diclazuril in comparison with chemical and ionophorous anticoccidials against Eimeria spp. in broiler chickens in floor pens.	2001-04	11297280

Patents

Sample Use Guides

In Vivo Use Guide

Use 1 lb (454 g) of Zoamix per 2,000 lb (909 kg) of finished product to produce a feed containing 0.0125% dinitolmide (for chickens grown for meat purposes), use 1.5 lb (681 g) of Zoamix per ton (2,000 lb) of feed to produce a finished feed containing 0.0187% dinitolmide (for turkeys grown for meat purposes).

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:34:53 GMT 2025` Edited by `admin` on `Mon Mar 31 17:34:53 GMT 2025`
Record UNII	AOX68RY4TV
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

DINITOLMIDE

Official Name

English

D.O.T.

Preferred Name

English

DINITOLMIDE [MART.]

Common Name

English

3,5-DINITRO-O-TOLUAMIDE

Common Name

English

NSC-758213

Code

English

ZOALENE [GREEN BOOK]

Common Name

English

DINITROTOLUAMIDE

Systematic Name

English

ZOALENE

Common Name

English

dinitolmide [INN]

Common Name

English

DINITOLMIDE [HSDB]

Common Name

English

ZOAMIX

Brand Name

English

DINITOLMIDE [MI]

Common Name

English

ZOALELE

Brand Name

English

METHYLDINITROBENZAMIDE

Systematic Name

English

Classification Tree Code System Code

CFR

21 CFR 558.680