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Details

Stereochemistry ACHIRAL
Molecular Formula C16H20N2O4S2
Molecular Weight 368.471
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of PYRITINOL

SMILES

CC1=NC=C(CSSCC2=CN=C(C)C(O)=C2CO)C(CO)=C1O

InChI

InChIKey=SIXLXDIJGIWWFU-UHFFFAOYSA-N
InChI=1S/C16H20N2O4S2/c1-9-15(21)13(5-19)11(3-17-9)7-23-24-8-12-4-18-10(2)16(22)14(12)6-20/h3-4,19-22H,5-8H2,1-2H3

HIDE SMILES / InChI

Molecular Formula C16H20N2O4S2
Molecular Weight 368.471
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Pyritinol is a semi natural analogue of water soluble vitamin B6. Pyritinol was synthetized way back in 1961 by Merck Laboratories. After years of research, it entered the market in the 1970s, where it was used for clinical applications – including treating stroke patients and those with Alzheimer’s. Since the 1990s, it has been sold as a nootropic dietary supplement in the United States and many other parts of the world. Pyritinol, unlike many other nootropics, has been approved for use as a medical treatment in countries around the world. Doctors in many European countries use Pyritinol to treat patients with chronic degenerative brain disorders – like dementia. Countries where Pyritinol is an approved treatment include Austria, Germany, France, Greece, Italy, and Portugal. France has approved the use of Pyritinol – but only as a treatment for rheumatoid arthritis. Pyritinol is not currently licensed for use in the United Kingdom, but in most other countries, it’s available online or through drug stores as an over the counter substance. Pyritinol is marketed under the brand names Encephabol, Encefabol and Cerbon 6. One of the known mechanisms of action of Pyritinol involves increasing choline uptake into your neurons and thereby increasing acetylcholine levels. Pyritinol is also a great effective precursor to dopamine, which is one of the neurotransmitter mood-boosters in the brain. Pyritinol has better conversion into the neurochemical. This drug increases dopamine, which can keep the brain from anxiety because a lower dopamine level is connected to mood disorders and depression.

CNS Activity

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Encephabol
Primary
Encephabol
Primary
Encephabol

Doses

AEs

PubMed

Sample Use Guides

In Vivo Use Guide
Encephabol (Pyritinol) comes in coated tablets. The dosage depends on the severity of the patients condition. Tablets should be taken with meal and a large glass of water. Dosage for adults: 600 mg a day (2 tabs 3 times a day). Dosage for newborn infants: on the third day of life 20 mg a day during a month. Dosage for pediatric patients: 2 months: the dosage is increases 20 mg every next week until the daily dose will be 100 mg. 1-7 years old: 50-300 mg a day. 7 years old and over: 50-600 mg a day (1-2 tabs 1-3 times a day). In patients with chronic conditions the period of therapy should be no less than 8 weeks.
Route of Administration: Oral
In Vitro Use Guide
Pretreatment of rabbit peritoneal neutrophils with Pyritinol had an inhibitory effect on random migration or fMLP-activated chemotaxis at high concentrations (1 mM), and a slight potentiating effect at low concentrations (10 uM)
Substance Class Chemical
Record UNII
AK5Q5FZH2R
Record Status Validated (UNII)
Record Version