Details
Stereochemistry | ACHIRAL |
Molecular Formula | C16H20N2O4S2 |
Molecular Weight | 368.471 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=NC=C(CSSCC2=CN=C(C)C(O)=C2CO)C(CO)=C1O
InChI
InChIKey=SIXLXDIJGIWWFU-UHFFFAOYSA-N
InChI=1S/C16H20N2O4S2/c1-9-15(21)13(5-19)11(3-17-9)7-23-24-8-12-4-18-10(2)16(22)14(12)6-20/h3-4,19-22H,5-8H2,1-2H3
Molecular Formula | C16H20N2O4S2 |
Molecular Weight | 368.471 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Pyritinol is a semi natural analogue of water soluble vitamin B6. Pyritinol was synthetized way back in 1961 by Merck Laboratories. After years of research, it entered the market in the 1970s, where it was used for clinical applications – including treating stroke patients and those with Alzheimer’s. Since the 1990s, it has been sold as a nootropic dietary supplement in the United States and many other parts of the world. Pyritinol, unlike many other nootropics, has been approved for use as a medical treatment in countries around the world. Doctors in many European countries use Pyritinol to treat patients with chronic degenerative brain disorders – like dementia. Countries where Pyritinol is an approved treatment include Austria, Germany, France, Greece, Italy, and Portugal. France has approved the use of Pyritinol – but only as a treatment for rheumatoid arthritis. Pyritinol is not currently licensed for use in the United Kingdom, but in most other countries, it’s available online or through drug stores as an over the counter substance. Pyritinol is marketed under the brand names Encephabol, Encefabol and Cerbon 6. One of the known mechanisms of action of Pyritinol involves increasing choline uptake into your neurons and thereby increasing acetylcholine levels. Pyritinol is also a great effective precursor to dopamine, which is one of the neurotransmitter mood-boosters in the brain. Pyritinol has better conversion into the neurochemical. This drug increases dopamine, which can keep the brain from anxiety because a lower dopamine level is connected to mood disorders and depression.
Originator
Sources: https://nootriment.com/pyritinol/ | http://www.purenootropic.com/cholinergics/pyritinol/
Curator's Comment: Pyritinol was initially developed by Merck Laboratories in the year 1961 # Merck
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Primary | Encephabol Approved UseIndications: symptomatic treatment of chronic disorders of the brain function in dementia syndromes with the following symptoms: impaired memory and thinking, decreased concentration, fatigue, lack of incentives and motivation, affective disorders.
Primary degenerative dementia, dementia of vascular origin and mixed forms. Symptomatic treatment of chronic disorders of mental disability. Post-traumatic encephalopathy. Cerebral atherosclerosis. The consequences of encephalitis. Mental retardation, tserebrastenichesky syndrome, encephalopathy in children. |
|||
Primary | Encephabol Approved UseIndications: symptomatic treatment of chronic disorders of the brain function in dementia syndromes with the following symptoms: impaired memory and thinking, decreased concentration, fatigue, lack of incentives and motivation, affective disorders.
Primary degenerative dementia, dementia of vascular origin and mixed forms. Symptomatic treatment of chronic disorders of mental disability. Post-traumatic encephalopathy. Cerebral atherosclerosis. The consequences of encephalitis. Mental retardation, tserebrastenichesky syndrome, encephalopathy in children. |
|||
Primary | Encephabol Approved UseEncephabol stimulates the central nervous system and belongs to the group of drugs for treating Alzheimer's disease.
USES
Erradicate Physical and Psychological Weakness
Treat Alzheimer's Disease
Reduce Memory Impairment
Get Rid of Hangovers
Reduce Learning Disorders
Sequelae of Craniocerebral Trauma |
PubMed
Title | Date | PubMed |
---|---|---|
Effect of nicergoline on learning and memory. | 1988 Jul |
|
Stability-indicating electrochemical methods for the determination of meclophenoxate hydrochloride and pyritinol dihydrochloride using ion-selective membrane electrodes. | 2007 Jan |
|
Pyritinol reduces nociception and oxidative stress in diabetic rats. | 2008 Aug 20 |
|
Stability-indicating chemometric methods for the determination of pyritinol dihydrochloride. | 2009 May |
|
Selective Vulnerabilities of N-methyl-D-aspartate (NMDA) Receptors During Brain Aging. | 2010 |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: http://rupharma.com/encephabol/
Encephabol (Pyritinol) comes in coated tablets.
The dosage depends on the severity of the patients condition.
Tablets should be taken with meal and a large glass of water.
Dosage for adults: 600 mg a day (2 tabs 3 times a day).
Dosage for newborn infants: on the third day of life 20 mg a day during a month.
Dosage for pediatric patients: 2 months: the dosage is increases 20 mg every next week until the daily dose will be 100 mg.
1-7 years old: 50-300 mg a day.
7 years old and over: 50-600 mg a day (1-2 tabs 1-3 times a day).
In patients with chronic conditions the period of therapy should be no less than 8 weeks.
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/8397168
Pretreatment of rabbit peritoneal neutrophils with Pyritinol had
an inhibitory effect on random migration or fMLP-activated
chemotaxis at high concentrations (1 mM),
and a slight potentiating effect at low concentrations
(10 uM)
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:36:47 GMT 2023
by
admin
on
Fri Dec 15 16:36:47 GMT 2023
|
Record UNII |
AK5Q5FZH2R
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
|
Official Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English |
Classification Tree | Code System | Code | ||
---|---|---|---|---|
|
WHO-ATC |
N06BX02
Created by
admin on Fri Dec 15 16:36:47 GMT 2023 , Edited by admin on Fri Dec 15 16:36:47 GMT 2023
|
||
|
DSLD |
1890 (Number of products:1)
Created by
admin on Fri Dec 15 16:36:47 GMT 2023 , Edited by admin on Fri Dec 15 16:36:47 GMT 2023
|
||
|
NCI_THESAURUS |
C47795
Created by
admin on Fri Dec 15 16:36:47 GMT 2023 , Edited by admin on Fri Dec 15 16:36:47 GMT 2023
|
||
|
WHO-VATC |
QN06BX02
Created by
admin on Fri Dec 15 16:36:47 GMT 2023 , Edited by admin on Fri Dec 15 16:36:47 GMT 2023
|
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
9020
Created by
admin on Fri Dec 15 16:36:47 GMT 2023 , Edited by admin on Fri Dec 15 16:36:47 GMT 2023
|
PRIMARY | RxNorm | ||
|
m9379
Created by
admin on Fri Dec 15 16:36:47 GMT 2023 , Edited by admin on Fri Dec 15 16:36:47 GMT 2023
|
PRIMARY | Merck Index | ||
|
759229
Created by
admin on Fri Dec 15 16:36:47 GMT 2023 , Edited by admin on Fri Dec 15 16:36:47 GMT 2023
|
PRIMARY | |||
|
214-150-1
Created by
admin on Fri Dec 15 16:36:47 GMT 2023 , Edited by admin on Fri Dec 15 16:36:47 GMT 2023
|
PRIMARY | |||
|
CHEMBL488093
Created by
admin on Fri Dec 15 16:36:47 GMT 2023 , Edited by admin on Fri Dec 15 16:36:47 GMT 2023
|
PRIMARY | |||
|
C74239
Created by
admin on Fri Dec 15 16:36:47 GMT 2023 , Edited by admin on Fri Dec 15 16:36:47 GMT 2023
|
PRIMARY | |||
|
1098-97-1
Created by
admin on Fri Dec 15 16:36:47 GMT 2023 , Edited by admin on Fri Dec 15 16:36:47 GMT 2023
|
PRIMARY | |||
|
DTXSID3048362
Created by
admin on Fri Dec 15 16:36:47 GMT 2023 , Edited by admin on Fri Dec 15 16:36:47 GMT 2023
|
PRIMARY | |||
|
D011746
Created by
admin on Fri Dec 15 16:36:47 GMT 2023 , Edited by admin on Fri Dec 15 16:36:47 GMT 2023
|
PRIMARY | |||
|
100000080851
Created by
admin on Fri Dec 15 16:36:47 GMT 2023 , Edited by admin on Fri Dec 15 16:36:47 GMT 2023
|
PRIMARY | |||
|
SUB10175MIG
Created by
admin on Fri Dec 15 16:36:47 GMT 2023 , Edited by admin on Fri Dec 15 16:36:47 GMT 2023
|
PRIMARY | |||
|
2333
Created by
admin on Fri Dec 15 16:36:47 GMT 2023 , Edited by admin on Fri Dec 15 16:36:47 GMT 2023
|
PRIMARY | |||
|
AK5Q5FZH2R
Created by
admin on Fri Dec 15 16:36:47 GMT 2023 , Edited by admin on Fri Dec 15 16:36:47 GMT 2023
|
PRIMARY | |||
|
DB13084
Created by
admin on Fri Dec 15 16:36:47 GMT 2023 , Edited by admin on Fri Dec 15 16:36:47 GMT 2023
|
PRIMARY | |||
|
1308
Created by
admin on Fri Dec 15 16:36:47 GMT 2023 , Edited by admin on Fri Dec 15 16:36:47 GMT 2023
|
PRIMARY | |||
|
PYRITINOL
Created by
admin on Fri Dec 15 16:36:47 GMT 2023 , Edited by admin on Fri Dec 15 16:36:47 GMT 2023
|
PRIMARY | |||
|
14190
Created by
admin on Fri Dec 15 16:36:47 GMT 2023 , Edited by admin on Fri Dec 15 16:36:47 GMT 2023
|
PRIMARY |
Related Record | Type | Details | ||
---|---|---|---|---|
|
SALT/SOLVATE -> PARENT |
Related Record | Type | Details | ||
---|---|---|---|---|
|
ACTIVE MOIETY |