PIRIDRONIC ACID

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H11NO6P2
Molecular Weight	267.1129
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OP(O)(=O)C(CC1=NC=CC=C1)P(O)(O)=O

InChI

InChIKey=NGMZSXZBZNXBGX-UHFFFAOYSA-N

InChI=1S/C7H11NO6P2/c9-15(10,11)7(16(12,13)14)5-6-3-1-2-4-8-6/h1-4,7H,5H2,(H2,9,10,11)(H2,12,13,14)

HIDE SMILES / InChI

Molecular Formula	C7H11NO6P2
Molecular Weight	267.1129
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9052507 | https://www.ncbi.nlm.nih.gov/pubmed/18327899 | https://apps.who.int/iris/bitstream/handle/10665/275696/WHO-EMP-RHT-TSN-2013.1-eng.pdf | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 995, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ

Piridronic acid is pyridinyl bisphosphonate. It is the bone calcium metabolism regulator. Piridronic acid was used for the treatment of osteoporosis. It is the human farnesyl pyrophosphate synthase inhibitor. When expressed on an actual or anticipated clinical dose basis for osteoporosis piridronic acid may have a greater potential for inducing gastric damage than do pyridinyl bisphosphonates. Piridronic acid induced significantly more antral damage than risedronate and a greater number of lesions compared to pamidronate and risedronate.

Approval Year

PubMed

Title	Date	PubMed

Substance Class	Chemical Created by `admin` on `Sat Dec 16 05:44:15 GMT 2023` Edited by `admin` on `Sat Dec 16 05:44:15 GMT 2023`
Record UNII	ADD4H8T3K9
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PIRIDRONIC ACID

Official Name

English

piridronic acid [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C2136