Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C7H11NO6P2 |
| Molecular Weight | 267.1129 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OP(O)(=O)C(CC1=NC=CC=C1)P(O)(O)=O
InChI
InChIKey=NGMZSXZBZNXBGX-UHFFFAOYSA-N
InChI=1S/C7H11NO6P2/c9-15(10,11)7(16(12,13)14)5-6-3-1-2-4-8-6/h1-4,7H,5H2,(H2,9,10,11)(H2,12,13,14)
| Molecular Formula | C7H11NO6P2 |
| Molecular Weight | 267.1129 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Piridronic acid is pyridinyl bisphosphonate. It is the bone calcium metabolism regulator. Piridronic acid was used for the treatment of osteoporosis. It is the human farnesyl pyrophosphate synthase inhibitor. When expressed on an actual or anticipated clinical dose basis for osteoporosis piridronic acid may have a greater potential for inducing gastric damage than do pyridinyl bisphosphonates. Piridronic acid induced significantly more antral damage than risedronate and a greater number of lesions compared to pamidronate and risedronate.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Nonclinical model for assessing gastric effects of bisphosphonates. | 1997 Feb |
|
| Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase. | 2008 Apr 10 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 05:44:15 GMT 2023
by
admin
on
Sat Dec 16 05:44:15 GMT 2023
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| Record UNII |
ADD4H8T3K9
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| Record Status |
Validated (UNII)
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| Record Version |
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Common Name | English |
| Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C2136
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NCI_THESAURUS |
C67439
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NCI_THESAURUS |
C443
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75755-07-6
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57637
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SUB09912MIG
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C66420
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DTXSID50226652
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6043
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CHEMBL99369
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ADD4H8T3K9
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100000081667
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| Related Record | Type | Details | ||
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SALT/SOLVATE -> PARENT |
| Related Record | Type | Details | ||
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ACTIVE MOIETY |
