PIRIDRONATE SODIUM

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H10NO6P2.Na
Molecular Weight	289.0947
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].OP(O)(=O)C(CC1=CC=CC=N1)P(O)([O-])=O

InChI

InChIKey=LZNFXJFOLTVFOP-UHFFFAOYSA-M

InChI=1S/C7H11NO6P2.Na/c9-15(10,11)7(16(12,13)14)5-6-3-1-2-4-8-6;/h1-4,7H,5H2,(H2,9,10,11)(H2,12,13,14);/q;+1/p-1

HIDE SMILES / InChI

Molecular Formula	Na
Molecular Weight	22.9898
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C7H10NO6P2
Molecular Weight	266.1049
Charge	-1
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9052507 | https://www.ncbi.nlm.nih.gov/pubmed/18327899 | https://apps.who.int/iris/bitstream/handle/10665/275696/WHO-EMP-RHT-TSN-2013.1-eng.pdf | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 995, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ

Piridronic acid is pyridinyl bisphosphonate. It is the bone calcium metabolism regulator. Piridronic acid was used for the treatment of osteoporosis. It is the human farnesyl pyrophosphate synthase inhibitor. When expressed on an actual or anticipated clinical dose basis for osteoporosis piridronic acid may have a greater potential for inducing gastric damage than do pyridinyl bisphosphonates. Piridronic acid induced significantly more antral damage than risedronate and a greater number of lesions compared to pamidronate and risedronate.

Approval Year

PubMed

Title	Date	PubMed

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:45:24 GMT 2023` Edited by `admin` on `Fri Dec 15 17:45:24 GMT 2023`
Record UNII	977W2XFR3R
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PIRIDRONATE SODIUM

Official Name

English

NE-97221

Code

English

NE 97221

Code

English

Sodium trihydrogen [2-(2-pyridyl)ethylidene]diphosphonate

Systematic Name

English

PIRIDRONATE SODIUM [USAN]

Common Name

English

PHOSPHONIC ACID, (2-(2-PYRIDINYL)ETHYLIDENE)BIS-, MONOSODIUM SALT

Common Name

English

Code System Code Type Description

ChEMBL

CHEMBL99369