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Details

Stereochemistry ABSOLUTE
Molecular Formula C17H23N5O4
Molecular Weight 361.3956
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of EMD-132338

SMILES

NC(=N)C1=CC=C(C=C1)N2C[C@@H](CN3CCN(CC(O)=O)CC3)OC2=O

InChI

InChIKey=BXTGCIBGRDGLNI-CQSZACIVSA-N
InChI=1S/C17H23N5O4/c18-16(19)12-1-3-13(4-2-12)22-10-14(26-17(22)25)9-20-5-7-21(8-6-20)11-15(23)24/h1-4,14H,5-11H2,(H3,18,19)(H,23,24)/t14-/m1/s1

HIDE SMILES / InChI

Molecular Formula C17H23N5O4
Molecular Weight 361.3956
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Gantofiban (or EMD 122 347) is an oral double prodrug of the drug, EMD 132338 and is GPIIb/IIIa antagonist. The drug participated in phase II clinical trials in Japan in patients with thrombosis. However, in May 2004, Yamanouchi, the developing company, announced that the study was discontinued. Besides gantofiban was involved in phase II trials, like a treatment option in patients with the acute coronary syndrome. However, further information is not available.

Approval Year

PubMed

PubMed

TitleDatePubMed
Substance Class Chemical
Created
by admin
on Fri Jul 07 00:55:05 UTC 2023
Edited
by admin
on Fri Jul 07 00:55:05 UTC 2023
Record UNII
9Y2SN3W6A3
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
EMD-132338
Code English
4-[[(5R)-3-[4-(Aminoiminomethyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-1-piperazineacetic acid
Systematic Name English
EMD132338
Code English
1-Piperazineacetic acid, 4-[[(5R)-3-[4-(aminoiminomethyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-
Systematic Name English
1-Piperazineacetic acid, 4-[[3-[4-(aminoiminomethyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-, (R)-
Systematic Name English
Code System Code Type Description
PUBCHEM
9950809
Created by admin on Fri Jul 07 00:55:05 UTC 2023 , Edited by admin on Fri Jul 07 00:55:05 UTC 2023
PRIMARY
FDA UNII
9Y2SN3W6A3
Created by admin on Fri Jul 07 00:55:05 UTC 2023 , Edited by admin on Fri Jul 07 00:55:05 UTC 2023
PRIMARY
CAS
167364-01-4
Created by admin on Fri Jul 07 00:55:05 UTC 2023 , Edited by admin on Fri Jul 07 00:55:05 UTC 2023
PRIMARY
Related Record Type Details
PRODRUG -> METABOLITE ACTIVE
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ACTIVE MOIETY