GANTOFIBAN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C21H29N5O6
Molecular Weight	447.4849
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCOC(=O)CN1CCN(C[C@@H]2CN(C(=O)O2)C3=CC=C(C=C3)C(=N)NC(=O)OC)CC1

InChI

InChIKey=YNBHAPKHWDNTMZ-QGZVFWFLSA-N

InChI=1S/C21H29N5O6/c1-3-31-18(27)14-25-10-8-24(9-11-25)12-17-13-26(21(29)32-17)16-6-4-15(5-7-16)19(22)23-20(28)30-2/h4-7,17H,3,8-14H2,1-2H3,(H2,22,23,28)/t17-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C21H29N5O6
Molecular Weight	447.4849
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/11755763 | https://kundoc.com/pdf-abstract-32bae3f3a322fc22e4e25dad1c47fe1997698.html | http://www.protext.cz/english/zprava.php?id=750 | https://adisinsight.springer.com/drugs/800010688
Curator's Comment: Only one scientific resource (PUBMED article) available.

Gantofiban (or EMD 122 347) is an oral double prodrug of the drug, EMD 132338 and is GPIIb/IIIa antagonist. The drug participated in phase II clinical trials in Japan in patients with thrombosis. However, in May 2004, Yamanouchi, the developing company, announced that the study was discontinued. Besides gantofiban was involved in phase II trials, like a treatment option in patients with the acute coronary syndrome. However, further information is not available.

Originator

Approval Year

PubMed

Title	Date	PubMed
Enantioseparation of gantofiban precursors on chiral stationary phases of the poly-(N-acryloyl amino acid derivative)-type.	2002 Jan 15	11755763

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:21:16 GMT 2023` Edited by `admin` on `Fri Dec 15 16:21:16 GMT 2023`
Record UNII	MRG9KH7HF6
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

GANTOFIBAN

Official Name

English

Gantofiban [WHO-DD]

Common Name

English

gantofiban [INN]

Common Name

English

4-(((5R)-3-(P-(CARBOXYAMIDINO)PHENYL)-2-OXO-5-OXAZOLIDINYL)METHYL)-1-PIPERAZINEACETIC ACID, 1-ETHYL METHYL ESTER

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29750