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Details

Stereochemistry ABSOLUTE
Molecular Formula C21H29N5O6
Molecular Weight 447.4849
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GANTOFIBAN

SMILES

CCOC(=O)CN1CCN(C[C@@H]2CN(C(=O)O2)C3=CC=C(C=C3)C(=N)NC(=O)OC)CC1

InChI

InChIKey=YNBHAPKHWDNTMZ-QGZVFWFLSA-N
InChI=1S/C21H29N5O6/c1-3-31-18(27)14-25-10-8-24(9-11-25)12-17-13-26(21(29)32-17)16-6-4-15(5-7-16)19(22)23-20(28)30-2/h4-7,17H,3,8-14H2,1-2H3,(H2,22,23,28)/t17-/m1/s1

HIDE SMILES / InChI

Molecular Formula C21H29N5O6
Molecular Weight 447.4849
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Gantofiban (or EMD 122 347) is an oral double prodrug of the drug, EMD 132338 and is GPIIb/IIIa antagonist. The drug participated in phase II clinical trials in Japan in patients with thrombosis. However, in May 2004, Yamanouchi, the developing company, announced that the study was discontinued. Besides gantofiban was involved in phase II trials, like a treatment option in patients with the acute coronary syndrome. However, further information is not available.

Approval Year

PubMed

PubMed

TitleDatePubMed
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:21:16 UTC 2023
Edited
by admin
on Fri Dec 15 16:21:16 UTC 2023
Record UNII
MRG9KH7HF6
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
GANTOFIBAN
INN   WHO-DD  
INN  
Official Name English
Gantofiban [WHO-DD]
Common Name English
gantofiban [INN]
Common Name English
4-(((5R)-3-(P-(CARBOXYAMIDINO)PHENYL)-2-OXO-5-OXAZOLIDINYL)METHYL)-1-PIPERAZINEACETIC ACID, 1-ETHYL METHYL ESTER
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29750
Created by admin on Fri Dec 15 16:21:16 UTC 2023 , Edited by admin on Fri Dec 15 16:21:16 UTC 2023
Code System Code Type Description
EPA CompTox
DTXSID70171433
Created by admin on Fri Dec 15 16:21:16 UTC 2023 , Edited by admin on Fri Dec 15 16:21:16 UTC 2023
PRIMARY
FDA UNII
MRG9KH7HF6
Created by admin on Fri Dec 15 16:21:16 UTC 2023 , Edited by admin on Fri Dec 15 16:21:16 UTC 2023
PRIMARY
NCI_THESAURUS
C73227
Created by admin on Fri Dec 15 16:21:16 UTC 2023 , Edited by admin on Fri Dec 15 16:21:16 UTC 2023
PRIMARY
PUBCHEM
9824864
Created by admin on Fri Dec 15 16:21:16 UTC 2023 , Edited by admin on Fri Dec 15 16:21:16 UTC 2023
PRIMARY
ChEMBL
CHEMBL78871
Created by admin on Fri Dec 15 16:21:16 UTC 2023 , Edited by admin on Fri Dec 15 16:21:16 UTC 2023
PRIMARY
CAS
183547-57-1
Created by admin on Fri Dec 15 16:21:16 UTC 2023 , Edited by admin on Fri Dec 15 16:21:16 UTC 2023
PRIMARY
INN
7836
Created by admin on Fri Dec 15 16:21:16 UTC 2023 , Edited by admin on Fri Dec 15 16:21:16 UTC 2023
PRIMARY
SMS_ID
300000036886
Created by admin on Fri Dec 15 16:21:16 UTC 2023 , Edited by admin on Fri Dec 15 16:21:16 UTC 2023
PRIMARY
Related Record Type Details
METABOLITE ACTIVE -> PRODRUG
Related Record Type Details
ACTIVE MOIETY