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Details

Stereochemistry RACEMIC
Molecular Formula C10H13N3O2
Molecular Weight 207.2291
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GUANOXAN

SMILES

NC(=N)NCC1COC2=C(O1)C=CC=C2

InChI

InChIKey=HIUVKVDQFXDZHU-UHFFFAOYSA-N
InChI=1S/C10H13N3O2/c11-10(12)13-5-7-6-14-8-3-1-2-4-9(8)15-7/h1-4,7H,5-6H2,(H4,11,12,13)

HIDE SMILES / InChI
Molecular Formula C10H13N3O2
Molecular Weight 207.2291
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description

Guanoxan is 2-guanidinomethylbenzo-1,4-dioxan. It acts as a blocker of alpha-2 adrenoceptors. The clinical use of this drug has been in the treatment of hypertension. Both systolic and diastolic pressures are lowered in the lying and standing positions.

Originator

Pfizer
420

Approval Year

Unknown
139,594

PubMed

Sample Use Guides

In Vivo Use Guide
The drug may be given orally initially at a dose of 20 mg. daily and doubled every fourth day until an effect is obtained. Where more rapid effect is desired, a loading dose of 40 mg. may be used.
Route of Administration: Oral
Substance Class Chemical
Record UNII
9V0MRL0R5Y
Record Status Validated (UNII)
Record Version
NIH
NCATS
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