GUANOXAN

Possibly Marketed Outside US

Details

Stereochemistry	RACEMIC
Molecular Formula	C10H13N3O2
Molecular Weight	207.2291
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC(=N)NCC1COC2=CC=CC=C2O1

InChI

InChIKey=HIUVKVDQFXDZHU-UHFFFAOYSA-N

InChI=1S/C10H13N3O2/c11-10(12)13-5-7-6-14-8-3-1-2-4-9(8)15-7/h1-4,7H,5-6H2,(H4,11,12,13)

HIDE SMILES / InChI

Molecular Formula	C10H13N3O2
Molecular Weight	207.2291
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14147778 | https://www.ncbi.nlm.nih.gov/pubmed/8095548 | https://www.ncbi.nlm.nih.gov/pubmed/14301998

Guanoxan is 2-guanidinomethylbenzo-1,4-dioxan. It acts as a blocker of alpha-2 adrenoceptors. The clinical use of this drug has been in the treatment of hypertension. Both systolic and diastolic pressures are lowered in the lying and standing positions.

Originator

Approval Year

PubMed

Title	Date	PubMed
Dihydroergotamine: an effective treatment for postural hypotension due to antihypertensive drugs (ganglion-blocking agents excepted).	1976	135643

Sample Use Guides

In Vivo Use Guide

The drug may be given orally initially at a dose of 20 mg. daily and doubled every fourth day until an effect is obtained. Where more rapid effect is desired, a loading dose of 40 mg. may be used.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:47:17 GMT 2025` Edited by `admin` on `Mon Mar 31 18:47:17 GMT 2025`
Record UNII	9V0MRL0R5Y
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

GUANOXAN [MI]

Preferred Name

English

GUANOXAN

Official Name

English

Guanoxan [WHO-DD]

Common Name

English

guanoxan [INN]

Common Name

English

GUANIDINE, (2,3-DIHYDRO-1,4-BENZODIOXIN-2-YLMETHYL)-

Systematic Name

English

Classification Tree Code System Code

WHO-ATC

C02CC03