GUANOXAN SULFATE

Details

Stereochemistry	RACEMIC
Molecular Formula	2C10H13N3O2.H2O4S
Molecular Weight	512.537
Optical Activity	( + / - )
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OS(O)(=O)=O.NC(=N)NCC1COC2=C(O1)C=CC=C2.NC(=N)NCC3COC4=C(O3)C=CC=C4

InChI

InChIKey=NSGHAKPGHCNTPS-UHFFFAOYSA-N

InChI=1S/2C10H13N3O2.H2O4S/c2*11-10(12)13-5-7-6-14-8-3-1-2-4-9(8)15-7;1-5(2,3)4/h2*1-4,7H,5-6H2,(H4,11,12,13);(H2,1,2,3,4)

HIDE SMILES / InChI

Molecular Formula	H2O4S
Molecular Weight	98.078
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C10H13N3O2
Molecular Weight	207.2291
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14147778 | https://www.ncbi.nlm.nih.gov/pubmed/8095548 | https://www.ncbi.nlm.nih.gov/pubmed/14301998

Guanoxan is 2-guanidinomethylbenzo-1,4-dioxan. It acts as a blocker of alpha-2 adrenoceptors. The clinical use of this drug has been in the treatment of hypertension. Both systolic and diastolic pressures are lowered in the lying and standing positions.

Originator

Approval Year

PubMed

Title	Date	PubMed
Dihydroergotamine: an effective treatment for postural hypotension due to antihypertensive drugs (ganglion-blocking agents excepted).	1976	135643

Sample Use Guides

In Vivo Use Guide

The drug may be given orally initially at a dose of 20 mg. daily and doubled every fourth day until an effect is obtained. Where more rapid effect is desired, a loading dose of 40 mg. may be used.

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:04:19 GMT 2023` Edited by `admin` on `Fri Dec 15 15:04:19 GMT 2023`
Record UNII	N6IT80R85G
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

GUANOXAN SULFATE

Official Name

English

GUANOXAN SULPHATE

Common Name

English

GUANOXAN SULFATE [USAN]

Common Name

English

3-01003

Code

English

ENVACAR

Brand Name

English

NSC-108162

Code

English

(1,4-BENZODIOXAN-2-YL-METHYL)GUANIDINE SULFATE (2:1)

Systematic Name

English

GUANIDINE, (2,3-DIHYDRO-1,4-BENZODIOXIN-2-YLMETHYL)-, SULFATE (2:1)

Systematic Name

English

GUANIDINE, (2,3-DIHYDRO-1,4-BENZODIOXIN-2-YLMETHYL)-, SULPHATE (2:1)

Systematic Name

English

(1,4-BENZODIOXAN-2-YL-METHYL)GUANIDINE SULPHATE (2:1)

Systematic Name

English

Guanoxan sulfate [WHO-DD]

Common Name

English

GUANOXAN SULFATE [MART.]

Common Name

English

GUANOXAN SULFATE [MI]

Common Name

English

Code System Code Type Description

SMS_ID

100000086696