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Details

Stereochemistry ACHIRAL
Molecular Formula C22H28N4O3
Molecular Weight 396.4827
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ETONITAZENE

SMILES

CCOC1=CC=C(CC2=NC3=C(C=CC(=C3)[N+]([O-])=O)N2CCN(CC)CC)C=C1

InChI

InChIKey=PXDBZSCGSQSKST-UHFFFAOYSA-N
InChI=1S/C22H28N4O3/c1-4-24(5-2)13-14-25-21-12-9-18(26(27)28)16-20(21)23-22(25)15-17-7-10-19(11-8-17)29-6-3/h7-12,16H,4-6,13-15H2,1-3H3

HIDE SMILES / InChI

Molecular Formula C22H28N4O3
Molecular Weight 396.4827
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Etonitazene is a potent and selective mu-opioid agonist. It was developed in CIBA. Administration of etonitazene may induce respiratory depression, and therefor etonitazene is not used in humans. Etonitazene is explicitly listed as an illegal drug under UN convention and is illegal throughout the world.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
0.5 nM [Ki]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Standard binding and functional assays related to medications development division testing for potential cocaine and opiate narcotic treatment medications.
1998 Mar
Patents

Sample Use Guides

In rat tail-withdrawal assay, etonitazene was administered subcutaneously. ED50 was 0.38 mg/kg.
Route of Administration: Other
In Vitro Use Guide
Binding of etonitazene to mu-opioid receptors from the membrane fraction of rat brains (minus cerebellum) was studied using [3H]DAMGO as a radioligand. Etonitazene binds to mu-opioid receptors with Ki of 0.5 nM.
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:10:57 GMT 2023
Edited
by admin
on Fri Dec 15 16:10:57 GMT 2023
Record UNII
9U3GT3353T
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ETONITAZENE
INN   MI   WHO-DD  
INN  
Official Name English
1-(2-DIETHYLAMINOETHYL)-2-(P-ETHOXYBENZYL)-5-NITROBENZIMIDAZOLE
Common Name English
ETONITAZENE [MI]
Common Name English
etonitazene [INN]
Common Name English
1H-BENZIMIDAZOLE-1-ETHANAMINE, 2-((4-ETHOXYPHENYL)METHYL)-N,N-DIETHYL-5-NITRO-
Systematic Name English
CIBA 20-684BA
Common Name English
ARC 1G2
Common Name English
BA-20684
Code English
NIH 7607
Code English
NIH-7607
Code English
IDS-NE-006
Code English
ETOBEDOLUM
Common Name English
ACSCN-9624
Common Name English
Etonitazene [WHO-DD]
Common Name English
ETONITAZINE
Common Name English
Classification Tree Code System Code
DEA NO. 9624
Created by admin on Fri Dec 15 16:10:58 GMT 2023 , Edited by admin on Fri Dec 15 16:10:58 GMT 2023
NCI_THESAURUS C241
Created by admin on Fri Dec 15 16:10:58 GMT 2023 , Edited by admin on Fri Dec 15 16:10:58 GMT 2023
WIKIPEDIA Designer-drugs-Etonitazene
Created by admin on Fri Dec 15 16:10:58 GMT 2023 , Edited by admin on Fri Dec 15 16:10:58 GMT 2023
Code System Code Type Description
WIKIPEDIA
ETONITAZENE
Created by admin on Fri Dec 15 16:10:58 GMT 2023 , Edited by admin on Fri Dec 15 16:10:58 GMT 2023
PRIMARY
DRUG BANK
DB01462
Created by admin on Fri Dec 15 16:10:58 GMT 2023 , Edited by admin on Fri Dec 15 16:10:58 GMT 2023
PRIMARY
MERCK INDEX
m5197
Created by admin on Fri Dec 15 16:10:58 GMT 2023 , Edited by admin on Fri Dec 15 16:10:58 GMT 2023
PRIMARY Merck Index
PUBCHEM
13493
Created by admin on Fri Dec 15 16:10:58 GMT 2023 , Edited by admin on Fri Dec 15 16:10:58 GMT 2023
PRIMARY
SMS_ID
100000082109
Created by admin on Fri Dec 15 16:10:58 GMT 2023 , Edited by admin on Fri Dec 15 16:10:58 GMT 2023
PRIMARY
MESH
C084835
Created by admin on Fri Dec 15 16:10:58 GMT 2023 , Edited by admin on Fri Dec 15 16:10:58 GMT 2023
PRIMARY
FDA UNII
9U3GT3353T
Created by admin on Fri Dec 15 16:10:58 GMT 2023 , Edited by admin on Fri Dec 15 16:10:58 GMT 2023
PRIMARY
INN
1073
Created by admin on Fri Dec 15 16:10:58 GMT 2023 , Edited by admin on Fri Dec 15 16:10:58 GMT 2023
PRIMARY
ChEMBL
CHEMBL312040
Created by admin on Fri Dec 15 16:10:58 GMT 2023 , Edited by admin on Fri Dec 15 16:10:58 GMT 2023
PRIMARY
EVMPD
SUB07334MIG
Created by admin on Fri Dec 15 16:10:58 GMT 2023 , Edited by admin on Fri Dec 15 16:10:58 GMT 2023
PRIMARY
CAS
911-65-9
Created by admin on Fri Dec 15 16:10:58 GMT 2023 , Edited by admin on Fri Dec 15 16:10:58 GMT 2023
PRIMARY
NCI_THESAURUS
C65596
Created by admin on Fri Dec 15 16:10:58 GMT 2023 , Edited by admin on Fri Dec 15 16:10:58 GMT 2023
PRIMARY
EPA CompTox
DTXSID6048919
Created by admin on Fri Dec 15 16:10:58 GMT 2023 , Edited by admin on Fri Dec 15 16:10:58 GMT 2023
PRIMARY
ECHA (EC/EINECS)
213-009-1
Created by admin on Fri Dec 15 16:10:58 GMT 2023 , Edited by admin on Fri Dec 15 16:10:58 GMT 2023
PRIMARY
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