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Details

Stereochemistry ABSOLUTE
Molecular Formula C24H23F3N4O
Molecular Weight 440.4608
Optical Activity UNSPECIFIED
Defined Stereocenters 3 / 3
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LGH-447

SMILES

C[C@@H]1C[C@H](N)C[C@@H](C1)C2=C(NC(=O)C3=NC(=C(F)C=C3)C4=C(F)C=CC=C4F)C=NC=C2

InChI

InChIKey=VRQXRVAKPDCRCI-ZNMIVQPWSA-N
InChI=1S/C24H23F3N4O/c1-13-9-14(11-15(28)10-13)16-7-8-29-12-21(16)31-24(32)20-6-5-19(27)23(30-20)22-17(25)3-2-4-18(22)26/h2-8,12-15H,9-11,28H2,1H3,(H,31,32)/t13-,14+,15-/m0/s1

HIDE SMILES / InChI

Molecular Formula C24H23F3N4O
Molecular Weight 440.4608
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 3 / 3
E/Z Centers 0
Optical Activity UNSPECIFIED

Approval Year

Substance Class Chemical
Created
by admin
on Sat Dec 16 11:20:59 GMT 2023
Edited
by admin
on Sat Dec 16 11:20:59 GMT 2023
Record UNII
9TG5O4V25H
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
LGH-447
Code English
N-(4-((1R,3S,5S)-3-AMINO-5-METHYLCYCLOHEXYL)-3-PYRIDINYL)-6-(2,6-DIFLUOROPHENYL)-5-FLUORO-2-PYRIDINECARBOXAMIDE
Systematic Name English
PIM-447
Code English
PIM KINASE INHIBITOR LGH447
Common Name English
LGH447
Code English
PIM 447 [WHO-DD]
Common Name English
2-PYRIDINECARBOXAMIDE, N-(4-((1R,3S,5S)-3-AMINO-5-METHYLCYCLOHEXYL)-3-PYRIDINYL)-6-(2,6-DIFLUOROPHENYL)-5-FLUORO-
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C1404
Created by admin on Sat Dec 16 11:20:59 GMT 2023 , Edited by admin on Sat Dec 16 11:20:59 GMT 2023
NCI_THESAURUS C129825
Created by admin on Sat Dec 16 11:20:59 GMT 2023 , Edited by admin on Sat Dec 16 11:20:59 GMT 2023
Code System Code Type Description
NCI_THESAURUS
C106259
Created by admin on Sat Dec 16 11:20:59 GMT 2023 , Edited by admin on Sat Dec 16 11:20:59 GMT 2023
PRIMARY
CAS
1210608-43-7
Created by admin on Sat Dec 16 11:20:59 GMT 2023 , Edited by admin on Sat Dec 16 11:20:59 GMT 2023
PRIMARY
MANUFACTURER PRODUCT INFORMATION
LGH-447
Created by admin on Sat Dec 16 11:20:59 GMT 2023 , Edited by admin on Sat Dec 16 11:20:59 GMT 2023
PRIMARY MedKoo CAT NO: 407201, CAS NO: 1210608-43-7Description: PIM447, also known as LGH447, is a potent Moloney murine leukemia (PIM) 1, 2, and 3 kinase inhibitor. Pan proviral insertion site of Moloney murine leukemia (PIM) 1, 2, and 3 kinase inhibitors have recently begun to be tested in humans to assess whether pan PIM kinase inhibition may provide benefit to cancer patients. PIM447 demonstrates in vivo target modulation (pS6RP), single agent antitumor activity in a KG-1 AML mouse xenograft model, and druglike properties suitable for development. PIM447 advanced into humans in 2012 and is currently being assessed in several phase I trials. (last updated: 6/17/2016).
SMS_ID
100000178339
Created by admin on Sat Dec 16 11:20:59 GMT 2023 , Edited by admin on Sat Dec 16 11:20:59 GMT 2023
PRIMARY
FDA UNII
9TG5O4V25H
Created by admin on Sat Dec 16 11:20:59 GMT 2023 , Edited by admin on Sat Dec 16 11:20:59 GMT 2023
PRIMARY
ChEMBL
CHEMBL3545194
Created by admin on Sat Dec 16 11:20:59 GMT 2023 , Edited by admin on Sat Dec 16 11:20:59 GMT 2023
PRIMARY
EVMPD
SUB194067
Created by admin on Sat Dec 16 11:20:59 GMT 2023 , Edited by admin on Sat Dec 16 11:20:59 GMT 2023
PRIMARY
DRUG BANK
DB14943
Created by admin on Sat Dec 16 11:20:59 GMT 2023 , Edited by admin on Sat Dec 16 11:20:59 GMT 2023
PRIMARY
PUBCHEM
44814409
Created by admin on Sat Dec 16 11:20:59 GMT 2023 , Edited by admin on Sat Dec 16 11:20:59 GMT 2023
PRIMARY
Related Record Type Details
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Related Record Type Details
ACTIVE MOIETY
Drug: PIM 447(Primary); Indications: Acute myeloid leukaemia, Myelodysplastic syndromes; Focus: Adverse reactions; Sponsor: Novartis Pharmaceuticals; Most Recent Events: 05 Apr 2016 Status changed from recruiting to active, no longer recruiting as reported by ClinicalTrials.gov., 25 Jan 2016 Planned end date changed from 1 Jan 2016 to 1 Jul 2016, as reported by ClinicalTrials.gov., 25 Jan 2016 Planned primary completion date changed from 1 Jan 2016 to 1 Jul 2016, as reported by ClinicalTrials.gov.