U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry RACEMIC
Molecular Formula C14H22N2O3
Molecular Weight 266.3361
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BUCOLOME

SMILES

CCCCC1C(=O)NC(=O)N(C2CCCCC2)C1=O

InChI

InChIKey=DVEQCIBLXRSYPH-UHFFFAOYSA-N
InChI=1S/C14H22N2O3/c1-2-3-9-11-12(17)15-14(19)16(13(11)18)10-7-5-4-6-8-10/h10-11H,2-9H2,1H3,(H,15,17,19)

HIDE SMILES / InChI
Molecular Formula C14H22N2O3
Molecular Weight 266.3361
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description
Curator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/18445991 and http://www.genome.jp/dbget-bin/www_bget?drug+D01661

Bucolome (Paramidine) is a barbiturate derivative. It is a non-steroidal anti-inflammatory drug, which is used in the treatment of chronic articular rheumatism. It has been used as a uricosuric and/or anti-inflammatory agent in Japan since 1967. Bucolome acts as a CYP2C9 inhibitor and reduces the metabolism of several commonly used drugs, which makes it useful for potentiating or extending the duration of action of those drugs, or reducing the production of unwanted metabolites.

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8297
 8.24 µM [Ki]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Approved
8429
PARAMIDIN

Approved Use

Antirheumatic and antigout drug
PubMed

PubMed

TitleDatePubMed
[Intraluminal ureteral hematoma complicating anticoagulant therapy].
2005 Jul
Patents

Patents

EP2448573A1
2
US2016058744
2
US2016090408
2

Sample Use Guides

In Vivo Use Guide
300 mg dose of bucolome once a day
Route of Administration: Oral
In Vitro Use Guide
Protein binding of furosemide (20 M) was significantly inhibited by 300 M bucolome in human serum
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:30:22 GMT 2023
Edited
by admin
on Fri Dec 15 16:30:22 GMT 2023
Record UNII
9T08RAL174
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BUCOLOME
INN   JAN   MART.   MI   WHO-DD  
INN  
Official Name English
BUCOLOME [JAN]
Common Name English
Bucolome [WHO-DD]
Common Name English
2,4,6(1H,3H,5H)-PYRIMIDINETRIONE, 5-BUTYL-1-CYCLOHEXYL-
Systematic Name English
5-N-BUTYL-1-CYCLOHEXYLBARBITURIC ACID
Common Name English
BUCOLOM
Common Name English
BUCOLOME [MI]
Common Name English
5-BUTYL-1-CYCLOHEXYLBARBITURIC ACID
Systematic Name English
bucolome [INN]
Common Name English
BARBITURIC ACID, 5-BUTYL-1-CYCLOHEXYL-
Common Name English
PARAMIDINE
Common Name English
BUCOLOME [MART.]
Common Name English
PARAMIDIN
Brand Name English
Classification Tree Code System Code
NCI_THESAURUS C257
Created by admin on Fri Dec 15 16:30:23 GMT 2023 , Edited by admin on Fri Dec 15 16:30:23 GMT 2023
Code System Code Type Description
CHEBI
31314
Created by admin on Fri Dec 15 16:30:23 GMT 2023 , Edited by admin on Fri Dec 15 16:30:23 GMT 2023
PRIMARY
INN
2284
Created by admin on Fri Dec 15 16:30:23 GMT 2023 , Edited by admin on Fri Dec 15 16:30:23 GMT 2023
PRIMARY
DRUG CENTRAL
3044
Created by admin on Fri Dec 15 16:30:23 GMT 2023 , Edited by admin on Fri Dec 15 16:30:23 GMT 2023
PRIMARY
ChEMBL
CHEMBL2106136
Created by admin on Fri Dec 15 16:30:23 GMT 2023 , Edited by admin on Fri Dec 15 16:30:23 GMT 2023
PRIMARY
MESH
C084817
Created by admin on Fri Dec 15 16:30:23 GMT 2023 , Edited by admin on Fri Dec 15 16:30:23 GMT 2023
PRIMARY
SMS_ID
100000085847
Created by admin on Fri Dec 15 16:30:23 GMT 2023 , Edited by admin on Fri Dec 15 16:30:23 GMT 2023
PRIMARY
FDA UNII
9T08RAL174
Created by admin on Fri Dec 15 16:30:23 GMT 2023 , Edited by admin on Fri Dec 15 16:30:23 GMT 2023
PRIMARY
WIKIPEDIA
BUCOLOME
Created by admin on Fri Dec 15 16:30:23 GMT 2023 , Edited by admin on Fri Dec 15 16:30:23 GMT 2023
PRIMARY
NCI_THESAURUS
C73080
Created by admin on Fri Dec 15 16:30:23 GMT 2023 , Edited by admin on Fri Dec 15 16:30:23 GMT 2023
PRIMARY
PUBCHEM
2461
Created by admin on Fri Dec 15 16:30:23 GMT 2023 , Edited by admin on Fri Dec 15 16:30:23 GMT 2023
PRIMARY
ECHA (EC/EINECS)
212-666-1
Created by admin on Fri Dec 15 16:30:23 GMT 2023 , Edited by admin on Fri Dec 15 16:30:23 GMT 2023
PRIMARY
CAS
841-73-6
Created by admin on Fri Dec 15 16:30:23 GMT 2023 , Edited by admin on Fri Dec 15 16:30:23 GMT 2023
PRIMARY
MERCK INDEX
m2745
Created by admin on Fri Dec 15 16:30:23 GMT 2023 , Edited by admin on Fri Dec 15 16:30:23 GMT 2023
PRIMARY Merck Index
EPA CompTox
DTXSID4048854
Created by admin on Fri Dec 15 16:30:23 GMT 2023 , Edited by admin on Fri Dec 15 16:30:23 GMT 2023
PRIMARY
EVMPD
SUB05950MIG
Created by admin on Fri Dec 15 16:30:23 GMT 2023 , Edited by admin on Fri Dec 15 16:30:23 GMT 2023
PRIMARY
Related Record Type Details
Structure of BUCOLOME SODIUM
SALT/SOLVATE -> PARENT
Structure of BUCOLOME, (R)-
ENANTIOMER -> RACEMATE
Structure of BUCOLOME, (S)-
ENANTIOMER -> RACEMATE
Related Record Type Details
Structure of BUCOLOME
ACTIVE MOIETY
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966