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Details

Stereochemistry RACEMIC
Molecular Formula C14H22N2O3
Molecular Weight 266.3361
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BUCOLOME

SMILES

CCCCC1C(=O)NC(=O)N(C2CCCCC2)C1=O

InChI

InChIKey=DVEQCIBLXRSYPH-UHFFFAOYSA-N
InChI=1S/C14H22N2O3/c1-2-3-9-11-12(17)15-14(19)16(13(11)18)10-7-5-4-6-8-10/h10-11H,2-9H2,1H3,(H,15,17,19)

HIDE SMILES / InChI
Molecular Formula C14H22N2O3
Molecular Weight 266.3361
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description
Curator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/18445991 and http://www.genome.jp/dbget-bin/www_bget?drug+D01661

Bucolome (Paramidine) is a barbiturate derivative. It is a non-steroidal anti-inflammatory drug, which is used in the treatment of chronic articular rheumatism. It has been used as a uricosuric and/or anti-inflammatory agent in Japan since 1967. Bucolome acts as a CYP2C9 inhibitor and reduces the metabolism of several commonly used drugs, which makes it useful for potentiating or extending the duration of action of those drugs, or reducing the production of unwanted metabolites.

Approval Year

Unknown
149124
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8504
 8.24 µM [Ki]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Approved
8583
PARAMIDIN

Approved Use

Antirheumatic and antigout drug
PubMed

PubMed

TitleDatePubMed
[Intraluminal ureteral hematoma complicating anticoagulant therapy].
2005-07
Bucolome, a potent binding inhibitor for furosemide, alters the pharmacokinetics and diuretic effect of furosemide: potential for use of bucolome to restore diuretic response in nephrotic syndrome.
2005-04
Patents

Patents

EP2448573A1
2
US2016058744
2
US2016090408
2

Sample Use Guides

In Vivo Use Guide
300 mg dose of bucolome once a day
Route of Administration: Oral
In Vitro Use Guide
Protein binding of furosemide (20 M) was significantly inhibited by 300 M bucolome in human serum
Substance Class Chemical
Created
by admin
on Mon Mar 31 18:29:48 GMT 2025
Edited
by admin
on Mon Mar 31 18:29:48 GMT 2025
Record UNII
9T08RAL174
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BUCOLOME
INN   JAN   MART.   MI   WHO-DD  
INN  
Official Name English
PARAMIDIN
Preferred Name English
BUCOLOME [JAN]
Common Name English
Bucolome [WHO-DD]
Common Name English
2,4,6(1H,3H,5H)-PYRIMIDINETRIONE, 5-BUTYL-1-CYCLOHEXYL-
Systematic Name English
5-N-BUTYL-1-CYCLOHEXYLBARBITURIC ACID
Common Name English
BUCOLOM
Common Name English
BUCOLOME [MI]
Common Name English
5-BUTYL-1-CYCLOHEXYLBARBITURIC ACID
Systematic Name English
bucolome [INN]
Common Name English
BARBITURIC ACID, 5-BUTYL-1-CYCLOHEXYL-
Common Name English
PARAMIDINE
Common Name English
BUCOLOME [MART.]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C257
Created by admin on Mon Mar 31 18:29:48 GMT 2025 , Edited by admin on Mon Mar 31 18:29:48 GMT 2025
Code System Code Type Description
CHEBI
31314
Created by admin on Mon Mar 31 18:29:48 GMT 2025 , Edited by admin on Mon Mar 31 18:29:48 GMT 2025
PRIMARY
INN
2284
Created by admin on Mon Mar 31 18:29:48 GMT 2025 , Edited by admin on Mon Mar 31 18:29:48 GMT 2025
PRIMARY
DRUG CENTRAL
3044
Created by admin on Mon Mar 31 18:29:48 GMT 2025 , Edited by admin on Mon Mar 31 18:29:48 GMT 2025
PRIMARY
ChEMBL
CHEMBL2106136
Created by admin on Mon Mar 31 18:29:48 GMT 2025 , Edited by admin on Mon Mar 31 18:29:48 GMT 2025
PRIMARY
MESH
C084817
Created by admin on Mon Mar 31 18:29:48 GMT 2025 , Edited by admin on Mon Mar 31 18:29:48 GMT 2025
PRIMARY
SMS_ID
100000085847
Created by admin on Mon Mar 31 18:29:48 GMT 2025 , Edited by admin on Mon Mar 31 18:29:48 GMT 2025
PRIMARY
FDA UNII
9T08RAL174
Created by admin on Mon Mar 31 18:29:48 GMT 2025 , Edited by admin on Mon Mar 31 18:29:48 GMT 2025
PRIMARY
WIKIPEDIA
BUCOLOME
Created by admin on Mon Mar 31 18:29:48 GMT 2025 , Edited by admin on Mon Mar 31 18:29:48 GMT 2025
PRIMARY
NCI_THESAURUS
C73080
Created by admin on Mon Mar 31 18:29:48 GMT 2025 , Edited by admin on Mon Mar 31 18:29:48 GMT 2025
PRIMARY
PUBCHEM
2461
Created by admin on Mon Mar 31 18:29:48 GMT 2025 , Edited by admin on Mon Mar 31 18:29:48 GMT 2025
PRIMARY
ECHA (EC/EINECS)
212-666-1
Created by admin on Mon Mar 31 18:29:48 GMT 2025 , Edited by admin on Mon Mar 31 18:29:48 GMT 2025
PRIMARY
CAS
841-73-6
Created by admin on Mon Mar 31 18:29:48 GMT 2025 , Edited by admin on Mon Mar 31 18:29:48 GMT 2025
PRIMARY
MERCK INDEX
m2745
Created by admin on Mon Mar 31 18:29:48 GMT 2025 , Edited by admin on Mon Mar 31 18:29:48 GMT 2025
PRIMARY Merck Index
EPA CompTox
DTXSID4048854
Created by admin on Mon Mar 31 18:29:48 GMT 2025 , Edited by admin on Mon Mar 31 18:29:48 GMT 2025
PRIMARY
EVMPD
SUB05950MIG
Created by admin on Mon Mar 31 18:29:48 GMT 2025 , Edited by admin on Mon Mar 31 18:29:48 GMT 2025
PRIMARY
Related Record Type Details
Structure of BUCOLOME SODIUM
SALT/SOLVATE -> PARENT
Structure of BUCOLOME, (R)-
ENANTIOMER -> RACEMATE
Structure of BUCOLOME, (S)-
ENANTIOMER -> RACEMATE
Related Record Type Details
Structure of BUCOLOME
ACTIVE MOIETY
NIH
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