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Details

Stereochemistry RACEMIC
Molecular Formula C14H21N2O3.Na
Molecular Weight 288.3179
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of BUCOLOME SODIUM

SMILES

[Na+].CCCCC1C(=O)[N-]C(=O)N(C2CCCCC2)C1=O

InChI

InChIKey=SGESMFOVCAMYRA-UHFFFAOYSA-M
InChI=1S/C14H22N2O3.Na/c1-2-3-9-11-12(17)15-14(19)16(13(11)18)10-7-5-4-6-8-10;/h10-11H,2-9H2,1H3,(H,15,17,19);/q;+1/p-1

HIDE SMILES / InChI
Molecular Formula C14H22N2O3
Molecular Weight 266.3361
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )
Molecular Formula Na
Molecular Weight 22.98976928
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/18445991 and http://www.genome.jp/dbget-bin/www_bget?drug+D01661

Bucolome (Paramidine) is a barbiturate derivative. It is a non-steroidal anti-inflammatory drug, which is used in the treatment of chronic articular rheumatism. It has been used as a uricosuric and/or anti-inflammatory agent in Japan since 1967. Bucolome acts as a CYP2C9 inhibitor and reduces the metabolism of several commonly used drugs, which makes it useful for potentiating or extending the duration of action of those drugs, or reducing the production of unwanted metabolites.

Approval Year

Unknown
149124
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8504
 8.24 µM [Ki]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Approved
8583
PARAMIDIN

Approved Use

Antirheumatic and antigout drug
PubMed

PubMed

TitleDatePubMed
[Intraluminal ureteral hematoma complicating anticoagulant therapy].
2005-07
Bucolome, a potent binding inhibitor for furosemide, alters the pharmacokinetics and diuretic effect of furosemide: potential for use of bucolome to restore diuretic response in nephrotic syndrome.
2005-04
Patents

Patents

EP2448573A1
2
US2016058744
2
US2016090408
2

Sample Use Guides

In Vivo Use Guide
300 mg dose of bucolome once a day
Route of Administration: Oral
In Vitro Use Guide
Protein binding of furosemide (20 M) was significantly inhibited by 300 M bucolome in human serum
Substance Class Chemical
Created
by admin
on Mon Mar 31 23:31:38 GMT 2025
Edited
by admin
on Mon Mar 31 23:31:38 GMT 2025
Record UNII
0QN61326HC
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
BUCOLOME SODIUM
Common Name English
BUCOLOME SODIUM SALT
Preferred Name English
BARBITURIC ACID, 5-BUTYL-1-CYCLOHEXYL-, SODIUM SALT
Systematic Name English
2,4,6(1H,3H,5H)-PYRIMIDINETRIONE, 5-BUTYL-1-CYCLOHEXYL-, SODIUM SALT (1:1)
Systematic Name English
SODIUM 5-BUTYL-1-CYCLOHEXYL-2,4,6-TRIOXOPERHYDROPYRIMIDINE
Systematic Name English
SODIUM BUCOLOME
Common Name English
Code System Code Type Description
FDA UNII
0QN61326HC
Created by admin on Mon Mar 31 23:31:38 GMT 2025 , Edited by admin on Mon Mar 31 23:31:38 GMT 2025
PRIMARY
PUBCHEM
23670498
Created by admin on Mon Mar 31 23:31:38 GMT 2025 , Edited by admin on Mon Mar 31 23:31:38 GMT 2025
PRIMARY
CAS
6891-28-7
Created by admin on Mon Mar 31 23:31:38 GMT 2025 , Edited by admin on Mon Mar 31 23:31:38 GMT 2025
PRIMARY
EPA CompTox
DTXSID30988620
Created by admin on Mon Mar 31 23:31:38 GMT 2025 , Edited by admin on Mon Mar 31 23:31:38 GMT 2025
PRIMARY
Related Record Type Details
Structure of BUCOLOME
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of BUCOLOME
ACTIVE MOIETY
NIH
NCATS
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